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Previous Article | Next Article
The Journal of Neuroscience, September 15, 2000, 20(18):6830-6838
Ca2+/Calmodulin-Dependent Facilitation and Inactivation of P/Q-Type Ca2+ Channels
Amy Lee, Todd Scheuer, and William A. Catterall Department of Pharmacology, University of Washington, Seattle, Washington 98195-7280
Trains of action potentials cause Ca2+-dependent facilitation and inactivation of presynaptic P/Q-type Ca2+ channels that can alter synaptic efficacy. A potential mechanism for these effects involves calmodulin, which associates in a Ca2+-dependent manner with the pore-forming
1A subunit. Here, we report that Ca2+ and calmodulin dramatically enhance inactivation and facilitation of P/Q-type Ca2+ channels containing the auxiliary
2a subunit compared with their relatively small effects on channels with
Key words: calcium channel; calmodulin; synaptic plasticity; inactivation; facilitation; action potential
Copyright © 2000 Society for Neuroscience 0270-6474/00/20186830-09$05.00/0
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