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The Journal of Neuroscience, September 15, 2000, 20(18):7024-7036

Profound Amnesia After Damage to the Medial Temporal Lobe: A Neuroanatomical and Neuropsychological Profile of Patient E. P.

Lisa Stefanacci¹, Elizabeth A. Buffalo², Heike Schmolck¹, and Larry R. Squire^{1, 2, 3, 4}

Departments of ¹ Psychiatry, ² Neurosciences, and ³ Department of Psychology, University of California, La Jolla, California 92093, and ⁴ Veterans Affairs Medical Center, San Diego, California 92161

E. P. became profoundly amnesic in 1992 after viral encephalitis, which damaged his medial temporal lobe bilaterally. Because of the rarity of such patients, we have performed a detailed neuroanatomical analysis of E. P.'s lesion using magnetic resonance imaging, and we have assessed his cognitive abilities with a wide range of neuropsychological tests. Finally, we have compared and contrasted the findings for E. P. with the noted amnesic patient H.M, whose surgical lesion is strikingly similar to E. P.'s lesion.

Key words: memory; hippocampus; amnesia; E. P.; medial temporal lobe; encephalitis

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Copyright © 2000 Society for Neuroscience  0270-6474/00/20187024-13$05.00/0

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