 |
 Previous Article | Next Article 
The Journal of Neuroscience, September 15, 2000, 20(18):7059-7066
The Amygdala Modulates Memory Consolidation of Fear-Motivated
Inhibitory Avoidance Learning But Not Classical Fear Conditioning
Ann E.
Wilensky,
Glenn E.
Schafe, and
Joseph E.
LeDoux
W. M. Keck Foundation Laboratory of Neurobiology, Center for
Neural Science, New York University, New York, New York, 10003
Although the lateral and basal nuclei of the amygdala are believed
to be essential for the acquisition of Pavlovian fear conditioning, studies using post-training manipulations of the amygdala in the inhibitory avoidance learning paradigm have recently called this view
into question. We used the GABAA agonist muscimol to
functionally inactivate these nuclei immediately after single-trial
Pavlovian fear conditioning or single-trial inhibitory avoidance
learning. Immediate post-training infusions of muscimol had no effect
on Pavlovian conditioning but produced a dose-dependent effect on inhibitory avoidance. However, pre-training infusions dose-dependently disrupted Pavlovian conditioning. These findings indicate that the
amygdala plays an essential role in the acquisition of Pavlovian fear
conditioning and contributes to the modulation of memory consolidation
of inhibitory avoidance but not of Pavlovian fear conditioning.
Key words:
muscimol; memory; acquisition; consolidation; amygdala; inhibitory avoidance
Copyright © 2000 Society for Neuroscience 0270-6474/00/20187059-08$05.00/0
This article has been cited by other articles:
|
|
|
|
 
S. V. Mahler and K. C. Berridge
Which Cue to "Want?" Central Amygdala Opioid Activation Enhances and Focuses Incentive Salience on a Prepotent Reward Cue
J. Neurosci.,
May 20, 2009;
29(20):
6500 - 6513.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S.-H. Lee, J.-H. Choi, N. Lee, H.-R. Lee, J.-I. Kim, N.-K. Yu, S.-L. Choi, S.-H. Lee, H. Kim, and B.-K. Kaang
Synaptic Protein Degradation Underlies Destabilization of Retrieved Fear Memory
Science,
February 29, 2008;
319(5867):
1253 - 1256.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. D. Cohen and M. A. Castro-Alamancos
Early Sensory Pathways for Detection of Fearful Conditioned Stimuli: Tectal and Thalamic Relays
J. Neurosci.,
July 18, 2007;
27(29):
7762 - 7776.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. H. Milekic, G. Pollonini, and C. M. Alberini
Temporal requirement of C/EBP{beta} in the amygdala following reactivation but not acquisition of inhibitory avoidance
Learn. Mem.,
July 18, 2007;
14(7):
504 - 511.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. B. Stein, A. N. Simmons, J. S. Feinstein, and M. P. Paulus
Increased Amygdala and Insula Activation During Emotion Processing in Anxiety-Prone Subjects
Am J Psychiatry,
February 1, 2007;
164(2):
318 - 327.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. E. Wilensky, G. E. Schafe, M. P. Kristensen, and J. E. LeDoux
Rethinking the Fear Circuit: The Central Nucleus of the Amygdala Is Required for the Acquisition, Consolidation, and Expression of Pavlovian Fear Conditioning
J. Neurosci.,
November 29, 2006;
26(48):
12387 - 12396.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Benini and M. Avoli
Altered Inhibition in Lateral Amygdala Networks in a Rat Model of Temporal Lobe Epilepsy
J Neurophysiol,
April 1, 2006;
95(4):
2143 - 2154.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. A. R. Manzanares, N. A. Isoardi, H. F. Carrer, and V. A. Molina
Previous Stress Facilitates Fear Memory, Attenuates GABAergic Inhibition, and Increases Synaptic Plasticity in the Rat Basolateral Amygdala
J. Neurosci.,
September 21, 2005;
25(38):
8725 - 8734.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. C. Huff, K. J. Wright-Hardesty, E. A. Higgins, P. Matus-Amat, and J. W. Rudy
Context pre-exposure obscures amygdala modulation of contextual-fear conditioning
Learn. Mem.,
September 1, 2005;
12(5):
456 - 460.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. T. LaLumiere and J. L. McGaugh
Memory enhancement induced by post-training intrabasolateral amygdala infusions of {beta}-adrenergic or muscarinic agonists requires activation of dopamine receptors: Involvement of right, but not left, basolateral amygdala
Learn. Mem.,
September 1, 2005;
12(5):
527 - 532.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. E. Dityatev and V. Y. Bolshakov
Amygdala, Long-term Potentiation, and Fear Conditioning
Neuroscientist,
February 1, 2005;
11(1):
75 - 88.
[Abstract]
[PDF]
|
|
|
|
|
|
|
D. S. Charney
Psychobiological Mechanisms of Resilience and Vulnerability: Implications for Successful Adaptation to Extreme Stress
Focus,
July 1, 2004;
2(3):
368 - 391.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. R. Holahan and N. M. White
Intra-Amygdala Muscimol Injections Impair Freezing and Place Avoidance in Aversive Contextual Conditioning
Learn. Mem.,
July 1, 2004;
11(4):
436 - 446.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Rubin, D. B. Berlese, J. A. Stiegemeier, M. A. Volkweis, D. M. Oliveira, T. L. B. dos Santos, A. C. Fenili, and C. F. Mello
Intra-Amygdala Administration of Polyamines Modulates Fear Conditioning in Rats
J. Neurosci.,
March 3, 2004;
24(9):
2328 - 2334.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. S. Charney
Psychobiological Mechanisms of Resilience and Vulnerability: Implications for Successful Adaptation to Extreme Stress
Am J Psychiatry,
February 1, 2004;
161(2):
195 - 216.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. J. Berlau and J. L. McGaugh
Basolateral Amygdala Lesions Do Not Prevent Memory of Context-Footshock Training
Learn. Mem.,
November 1, 2003;
10(6):
495 - 502.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. T. LaLumiere, T.-V. Buen, and J. L. McGaugh
Post-Training Intra-Basolateral Amygdala Infusions of Norepinephrine Enhance Consolidation of Memory for Contextual Fear Conditioning
J. Neurosci.,
July 30, 2003;
23(17):
6754 - 6758.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Lehmann, D. Treit, and M. B. Parent
Spared Anterograde Memory for Shock-Probe Fear Conditioning After Inactivation of the Amygdala
Learn. Mem.,
July 1, 2003;
10(4):
261 - 269.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Savonenko, T. Werka, E. Nikolaev, K. Zielinski, and L. Kaczmarek
Complex Effects of NMDA Receptor Antagonist APV in the Basolateral Amygdala on Acquisition of Two-Way Avoidance Reaction and Long-Term Fear Memory
Learn. Mem.,
July 1, 2003;
10(4):
293 - 303.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Bouret, A. Duvel, S. Onat, and S. J. Sara
Phasic Activation of Locus Ceruleus Neurons by the Central Nucleus of the Amygdala
J. Neurosci.,
April 15, 2003;
23(8):
3491 - 3497.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. B. Stein, P. R. Goldin, J. Sareen, L. T. E. Zorrilla, and G. G. Brown
Increased Amygdala Activation to Angry and Contemptuous Faces in Generalized Social Phobia
Arch Gen Psychiatry,
November 1, 2002;
59(11):
1027 - 1034.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. M. Slimko, S. McKinney, D. J. Anderson, N. Davidson, and H. A. Lester
Selective Electrical Silencing of Mammalian Neurons In Vitro by the Use of Invertebrate Ligand-Gated Chloride Channels
J. Neurosci.,
September 1, 2002;
22(17):
7373 - 7379.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Vazdarjanova
Chasing "fear memories" to the cerebellum
PNAS,
June 11, 2002;
99(12):
7814 - 7815.
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. T. Blair, G. E. Schafe, E. P. Bauer, S. M. Rodrigues, and J. E. LeDoux
Synaptic Plasticity in the Lateral Amygdala: A Cellular Hypothesis of Fear Conditioning
Learn. Mem.,
September 1, 2001;
8(5):
229 - 242.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. Stork, S. Stork, H.-C. Pape, and K. Obata
Identification of Genes Expressed in the Amygdala During the Formation of Fear Memory
Learn. Mem.,
July 1, 2001;
8(4):
209 - 219.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. J. Wallace and J. B. Rosen
Neurotoxic Lesions of the Lateral Nucleus of the Amygdala Decrease Conditioned Fear But Not Unconditioned Fear of a Predator Odor: Comparison with Electrolytic Lesions
J. Neurosci.,
May 15, 2001;
21(10):
3619 - 3627.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Nader, P. Majidishad, P. Amorapanth, and J. E. LeDoux
Damage to the Lateral and Central, but Not Other, Amygdaloid Nuclei Prevents the Acquisition of Auditory Fear Conditioning
Learn. Mem.,
May 1, 2001;
8(3):
156 - 163.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Hall, K. L. Thomas, and B. J. Everitt
Cellular Imaging of zif268 Expression in the Hippocampus and Amygdala during Contextual and Cued Fear Memory Retrieval: Selective Activation of Hippocampal CA1 Neurons during the Recall of Contextual Memories
J. Neurosci.,
March 15, 2001;
21(6):
2186 - 2193.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
