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The Journal of Neuroscience, January 15, 2000, 20(2):813-819

Developmental Changes in Eye-Blink Conditioning and Neuronal Activity in the Cerebellar Interpositus Nucleus

John H. Freeman Jr and Daniel A. Nicholson

Department of Psychology, University of Iowa, Iowa City, Iowa 52242

Neuronal activity was recorded in the cerebellar interpositus nucleus in infant rats during classical conditioning of the eye-blink response. The percentage and amplitude of eye-blink conditioned responses increased as a function of postnatal age. Learning-specific neuronal activity in the cerebellum emerged ontogenetically in parallel with the eye-blink conditioned response. There were also age-specific changes in neuronal activity after the onset of the conditioned and unconditioned stimuli. The results indicate that the development of the eye-blink conditioned response may depend on the development of stimulus-evoked neuronal responses and learning-specific plasticity in the cerebellum. Functional immaturity in the afferent neural pathways may limit the induction of neural plasticity in the cerebellum and thereby limit the development of the eye-blink conditioned response.

Key words: ontogeny; cerebellum; interpositus; learning; conditioning; eye-blink

Copyright © 2000 Society for Neuroscience  0270-6474/00/202813-07$05.00/0


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