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The Journal of Neuroscience, October 15, 2000, 20(20):7657-7663
Evidence That Different Cation Chloride Cotransporters in Retinal Neurons Allow Opposite Responses to GABA
Noga Vardi1, Ling-Li Zhang1, John A. Payne2, and Peter Sterling1 1 University of Pennsylvania, Department of Neuroscience, Philadelphia, Pennsylvania 19104, and 2 University of California, Department of Human Physiology, Davis, California 95616
GABA gating an anion channel primarily permeable to chloride can hyperpolarize or depolarize, depending on whether the chloride equilibrium potential (ECl) is negative or positive, respectively, to the resting membrane potential (Erest). If the transmembrane Cl
gradient is set by active transport, those neurons or neuronal regions that exhibit opposite responses to GABA should express different chloride transporters. To test this, we immunostained retina for the K-Cl cotransporter (KCC2) that normally extrudes chloride and for the Na-K-Cl cotransporter (NKCC) that normally accumulates chloride. KCC2 was expressed wherever ECl is either known or predicted to be negative to Erest (ganglion cells, bipolar axons, and OFF bipolar dendrites), whereas NKCC was expressed wherever ECl is either known or predicted to be positive to Erest (horizontal cells and ON bipolar dendrites). Thus, in the retina, the opposite effects of GABA on different cell types and on different cellular regions are probably primarily determined by the differential targeting of these two chloride transporters.
Key words: GABA depolarization; receptive field; ECl; KCC; NKCC; retinal bipolar cells; horizontal cells
Copyright © 2000 Society for Neuroscience 0270-6474/00/20207657-07$05.00/0
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