 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, November 1, 2000, 20(21):8012-8020
A Glia-Derived Signal Regulating Neuronal Differentiation
Olivier Blondel1, Carlos Collin1, William J. McCarran1, Shiaoping Zhu1, Rachel Zamostiano2, Illana Gozes2, Douglas E. Brenneman3, and Ronald D. G. McKay1 1 Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, 2 Department of Clinical Biochemistry, Sackler School of Medicine, Tel Aviv, Israel 69978, and 3 Section on Developmental and Molecular Pharmacology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892
Astrocytes are present in large numbers in the nervous system, are associated with synapses, and propagate ionic signals. Astrocytes influence neuronal physiology by responding to and releasing neurotransmitters, but the mechanisms that establish the close interaction between these cells are not defined. Here we use hippocampal neurons in culture to demonstrate that vasoactive intestinal polypeptide (VIP) promotes neuronal differentiation through activity-dependent neurotrophic factor (ADNF), a protein secreted by VIP-stimulated astroglia. ADNF is produced by glial cells and acts directly on neurons to promote glutamate responses and morphological development. ADNF causes secretion of neurotrophin 3 (NT-3), and both proteins regulate NMDA receptor subunit 2A (NR2A) and NR2B. These data suggest that the VIP-ADNF-NT-3 neuronal-glial pathway regulates glutamate responses from an early stage in the synaptic development of excitatory neurons and may also contribute to the known effects of VIP on learning and behavior in the adult nervous system.
Key words: glia; synapse; hippocampus; ADNF; NT-3; VIP
Copyright © 2000 Society for Neuroscience 0270-6474/00/20218012-09$05.00/0
This article has been cited by other articles:
M. Guizzetti, N. H. Moore, G. Giordano, and L. G. Costa
Modulation of Neuritogenesis by Astrocyte Muscarinic Receptors
J. Biol. Chem., November 14, 2008; 283(46): 31884 - 31897.
[Abstract] [Full Text] [PDF]
H. Nishida and S. Okabe
Direct Astrocytic Contacts Regulate Local Maturation of Dendritic Spines
J. Neurosci., January 10, 2007; 27(2): 331 - 340.
[Abstract] [Full Text] [PDF]
F. Henle, C. Fischer, D. K. Meyer, and J. Leemhuis
Vasoactive Intestinal Peptide and PACAP38 Control N-Methyl-D-aspartic Acid-induced Dendrite Motility by Modifying the Activities of Rho GTPases and Phosphatidylinositol 3-Kinases
J. Biol. Chem., August 25, 2006; 281(34): 24955 - 24969.
[Abstract] [Full Text] [PDF]
R. Giau, J. Carrette, J. Bockaert, and V. Homburger
Constitutive Secretion of Protease Nexin-1 by Glial Cells and Its Regulation by G-Protein-Coupled Receptors
J. Neurosci., September 28, 2005; 25(39): 8995 - 9004.
[Abstract] [Full Text] [PDF]
L. Visochek, R. A. Steingart, I. Vulih-Shultzman, R. Klein, E. Priel, I. Gozes, and M. Cohen-Armon
PolyADP-Ribosylation Is Involved in Neurotrophic Activity
J. Neurosci., August 10, 2005; 25(32): 7420 - 7428.
[Abstract] [Full Text] [PDF]
S. B. Elmariah, E. J. Oh, E. G. Hughes, and R. J. Balice-Gordon
Astrocytes Regulate Inhibitory Synapse Formation via Trk-Mediated Modulation of Postsynaptic GABAA Receptors
J. Neurosci., April 6, 2005; 25(14): 3638 - 3650.
[Abstract] [Full Text] [PDF]
W. A. Lagreze, A. Pielen, R. Steingart, G. Schlunck, H.-D. Hofmann, I. Gozes, and M. Kirsch
The Peptides ADNF-9 and NAP Increase Survival and Neurite Outgrowth of Rat Retinal Ganglion Cells In Vitro
Invest. Ophthalmol. Vis. Sci., March 1, 2005; 46(3): 933 - 938.
[Abstract] [Full Text] [PDF]
M. F. Wilkemeyer, S.-y. Chen, C. E. Menkari, D. E. Brenneman, K. K. Sulik, and M. E. Charness
Differential effects of ethanol antagonism and neuroprotection in peptide fragment NAPVSIPQ prevention of ethanol-induced developmental toxicity
PNAS, July 8, 2003; 100(14): 8543 - 8548.
[Abstract] [Full Text] [PDF]
E. HANSSON and L. RONNBACK
Glial neuronal signaling in the central nervous system
FASEB J, March 1, 2003; 17(3): 341 - 348.
[Abstract] [Full Text] [PDF]
F. Ciccolini, T. J. Collins, J. Sudhoelter, P. Lipp, M. J. Berridge, and M. D. Bootman
Local and Global Spontaneous Calcium Events Regulate Neurite Outgrowth and Onset of GABAergic Phenotype during Neural Precursor Differentiation
J. Neurosci., January 1, 2003; 23(1): 103 - 111.
[Abstract] [Full Text] [PDF]
R. D. Fields and B. Stevens-Graham
NEUROSCIENCE: New Insights into Neuron-Glia Communication
Science, October 18, 2002; 298(5593): 556 - 562.
[Abstract] [Full Text] [PDF]
M. F. Wilkemeyer, C. E. Menkari, C. Y. Spong, and M. E. Charness
Peptide Antagonists of Ethanol Inhibition of L1-Mediated Cell-Cell Adhesion
J. Pharmacol. Exp. Ther., October 1, 2002; 303(1): 110 - 116.
[Abstract] [Full Text] [PDF]
A. Szklarczyk, J. Lapinska, M. Rylski, R. D. G. McKay, and L. Kaczmarek
Matrix Metalloproteinase-9 Undergoes Expression and Activation during Dendritic Remodeling in Adult Hippocampus
J. Neurosci., February 1, 2002; 22(3): 920 - 930.
[Abstract] [Full Text] [PDF]
H. Boukhaddaoui, V. Sieso, F. Scamps, and J. Valmier
An Activity-Dependent Neurotrophin-3 Autocrine Loop Regulates the Phenotype of Developing Hippocampal Pyramidal Neurons before Target Contact
J. Neurosci., November 15, 2001; 21(22): 8789 - 8797.
[Abstract] [Full Text] [PDF]
S. J. Servoss, S. J. Lee, G. Gibney, I. Gozes, D. E. Brenneman, and J. M. Hill
IGF-I as a Mediator of VIP/Activity-Dependent Neurotrophic Factor-Stimulated Embryonic Growth
Endocrinology, August 1, 2001; 142(8): 3348 - 3353.
[Abstract] [Full Text] [PDF]
K. Nagler, D. H Mauch, and F. W Pfrieger
Glia-derived signals induce synapse formation in neurones of the rat central nervous system
J. Physiol., June 15, 2001; 533(3): 665 - 679.
[Abstract] [Full Text] [PDF]
M. Krishna Temburni and M. H. Jacob
New functions for glia in the brain
PNAS, March 27, 2001; 98(7): 3631 - 3632.
[Full Text] [PDF]
|
|
|
|
 |
|