The Journal of Neuroscience, November 1, 2000, 20(21):8227-8227
CORRECTION
In the article "Neuronal Basic Helix-Loop-Helix
Proteins (NEX and BETA2/Neuro D) Regulate Terminal Granule Cell
Differentiation in the Hippocampus," by Markus H. Schwab, Angelika
Bartholomae, Bernd Heimrich, Dirk Feldmeyer, Silke Druffel-Augustin,
Sandra Goebbels, Frank J. Naya, Shanting Zhao, Michael
Frotscher, Ming-Jer Tsai, and Klaus-Armin
Nave, which appeared on pages 3714-3724 of the May 15, 2000 issue, the lower left graph of Figure 5C [the IV curve of a
control wild-type granule cell in the dentate gyrus (DG)]
is a duplication of another curve just above it [a control wild-type
pyramidal cell (CA3)]. The correct version of the figure, as well as the legend, is printed here.
View larger version (27K):
[in this window]
[in a new window]
|
B, Firing patterns of pyramidal cells (CA3,
top) and dentate GC (DG, bottom) recorded in wild-type
(WT, left) and NEX / *BETA2/NeuroD/ mice (DKO,
right). The membrane potential was set to 60 mV before action
potentials were elicited by injection of 1 sec current pulses. Note
that CA3 pyramidal cells of either genotype could fire regenerative
action potentials with peak amplitudes of 70-100 mV. In differentiated
GC, only nonregenerative action potentials (amplitude, 60 mV) could be
elicited. Presumptive GC in NEX/ *BETA2/NeuroD/ mice never
showed action potentials. Only a small current deflection on top
the voltage response was observed (arrow). Firing patterns
and current responses (C) are from the same neurons.
C, Current responses of CA3 pyramidal cells (top)
and dentate GC (bottom) in slices from wild-type
(left) and NEX/ *BETA2/NeuroD/ mice
(right). The membrane potential was held at 70 mV, and 10 mV voltage steps up to +100 mV were applied. Peak Na+
current generally exceeded 1 nA in CA3 pyramidal cells, but was smaller
in DG granule cells. Presumptive GC in NEX/ *BETA2/NeuroD/
mutants had peak Na+ currents <500 pA
(arrow).
|
|
