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The Journal of Neuroscience, November 15, 2000, 20(22):8485-8492

Distributed and Partially Separate Pools of Neurons Are Correlated with Two Different Components of the Gill-Withdrawal Reflex in Aplysia

Michal Zochowski^{1, 2, 5}, Lawrence B. Cohen^{1, 2}, Galit Fuhrmann^{2, 3}, and David Kleinfeld^{2, 4}

¹ Department of Molecular and Cellular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520, ² Marine Biological Laboratory, Woods Hole, Massachusetts 02543, ³ Center for Neural Computation, The Hebrew University, Jerusalem, Israel 91904, ⁴ Department of Physics, University of California at San Diego, La Jolla, California 92093-0319, and ⁵ Center for Theoretical Physics, Polish Academy of Science, 02-668 Warsaw, Poland

We compared the spike activity of individual neurons in the Aplysia abdominal ganglion with the movement of the gill during the gill-withdrawal reflex. We discriminated four populations that collectively encompass approximately half of the active neurons in the ganglion: (1) second-order sensory neurons that respond to the onset and offset of stimulation of the gill and are active before the movement starts; (2) neurons whose activity is correlated with the position of the gill and typically have a tonic output during gill withdrawal; (3) neurons whose activity is correlated with the velocity of the movement and typically fire in a phasic manner; and (4) neurons whose activity is correlated with both position and velocity. A reliable prediction of the position of the gill is achieved only with the combined output of 15-20 neurons, whereas a reliable prediction of the velocity depends on the combined output of 40 or more cells.

Key words: distributed activity; motor planning; neural coding; neural networks; optical recordings; optimal filtering

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Copyright © 2000 Society for Neuroscience  0270-6474/00/20228485-08$05.00/0

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