 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, November 15, 2000, 20(22):8577-8585
Initiating or Blocking Locomotion in Spinal Cats by Applying Noradrenergic Drugs to Restricted Lumbar Spinal Segments
Judith Marcoux and Serge Rossignol Centre de Recherche en Sciences Neurologiques, Faculté de Médecine, Université de Montréal, Montréal, Québec, Canada H3T 1J4
After an acute low thoracic spinal transection (T13), cats can be made to walk with the hindlimbs on a treadmill with clonidine, an
2-noradrenergic agonist. Because previous studies of neonatal rat spinal cord in vitro suggest that the most important lumbar segments for rhythmogenesis are L1-L2, we investigated the role of various lumbar segments in the initiation of walking movements on a treadmill of adult cats spinalized (T13), 5-6 d earlier. The locomotor activities were evaluated from electromyographic and video recordings. The results show that: (1) localized topical application of clonidine in restricted baths over either the L3-L4 or the L5-L7 segments was sufficient to induce walking movements. Yohimbine, an
Key words: spinal locomotion; central pattern generator; rhythm generation; midlumbar spinal cord; noradrenergic drugs; electromyography; kinematics
Copyright © 2000 Society for Neuroscience 0270-6474/00/20228577-09$05.00/0
This article has been cited by other articles:
B. R. Noga, D. M. G. Johnson, M. I. Riesgo, and A. Pinzon
Locomotor-Activated Neurons of the Cat. I. Serotonergic Innervation and Co-Localization of 5-HT7, 5-HT2A, and 5-HT1A Receptors in the Thoraco-Lumbar Spinal Cord
J Neurophysiol, September 1, 2009; 102(3): 1560 - 1576.
[Abstract] [Full Text] [PDF]
S. Rossignol, G. Barriere, O. Alluin, and A. Frigon
Re-expression of Locomotor Function After Partial Spinal Cord Injury
Physiology, April 1, 2009; 24(2): 127 - 139.
[Abstract] [Full Text] [PDF]
H. Delivet-Mongrain, H. Leblond, and S. Rossignol
Effects of Localized Intraspinal Injections of a Noradrenergic Blocker on Locomotion of High Decerebrate Cats
J Neurophysiol, August 1, 2008; 100(2): 907 - 921.
[Abstract] [Full Text] [PDF]
N. P. Lapointe, R.-V. Ung, P. Rouleau, and P. A. Guertin
Effects of Spinal {alpha}2-Adrenoceptor and I1-Imidazoline Receptor Activation on Hindlimb Movement Induction in Spinal Cord-Injured Mice
J. Pharmacol. Exp. Ther., June 1, 2008; 325(3): 994 - 1006.
[Abstract] [Full Text] [PDF]
D. Barthelemy, H. Leblond, and S. Rossignol
Characteristics and Mechanisms of Locomotion Induced by Intraspinal Microstimulation and Dorsal Root Stimulation in Spinal Cats
J Neurophysiol, March 1, 2007; 97(3): 1986 - 2000.
[Abstract] [Full Text] [PDF]
D. Barthelemy, H. Leblond, J. Provencher, and S. Rossignol
Nonlocomotor and Locomotor Hindlimb Responses Evoked by Electrical Microstimulation of the Lumbar Cord in Spinalized Cats
J Neurophysiol, December 1, 2006; 96(6): 3273 - 3292.
[Abstract] [Full Text] [PDF]
S. Rossignol
Plasticity of connections underlying locomotor recovery after central and/or peripheral lesions in the adult mammals
Phil Trans R Soc B, September 29, 2006; 361(1473): 1647 - 1671.
[Abstract] [Full Text] [PDF]
S. Rossignol, R. Dubuc, and J.-P. Gossard
Dynamic Sensorimotor Interactions in Locomotion
Physiol Rev, January 1, 2006; 86(1): 89 - 154.
[Abstract] [Full Text] [PDF]
P. Saltiel, K. Wyler-Duda, A. d'Avella, R. J. Ajemian, and E. Bizzi
Localization and Connectivity in Spinal Interneuronal Networks: The Adduction-Caudal Extension-Flexion Rhythm in the Frog
J Neurophysiol, September 1, 2005; 94(3): 2120 - 2138.
[Abstract] [Full Text] [PDF]
J. M. Wilson, R. Hartley, D. J. Maxwell, A. J. Todd, I. Lieberam, J. A. Kaltschmidt, Y. Yoshida, T. M. Jessell, and R. M. Brownstone
Conditional Rhythmicity of Ventral Spinal Interneurons Defined by Expression of the Hb9 Homeodomain Protein
J. Neurosci., June 15, 2005; 25(24): 5710 - 5719.
[Abstract] [Full Text] [PDF]
X. Dai, B. R. Noga, J. R. Douglas, and L. M. Jordan
Localization of Spinal Neurons Activated During Locomotion Using the c-fos Immunohistochemical Method
J Neurophysiol, June 1, 2005; 93(6): 3442 - 3452.
[Abstract] [Full Text] [PDF]
C. Langlet, H. Leblond, and S. Rossignol
Mid-Lumbar Segments Are Needed for the Expression of Locomotion in Chronic Spinal Cats
J Neurophysiol, May 1, 2005; 93(5): 2474 - 2488.
[Abstract] [Full Text] [PDF]
B. R. Noga, A. Pinzon, R. P. Mesigil, and I. D. Hentall
Steady-State Levels of Monoamines in the Rat Lumbar Spinal Cord: Spatial Mapping and the Effect of Acute Spinal Cord Injury
J Neurophysiol, July 1, 2004; 92(1): 567 - 577.
[Abstract] [Full Text] [PDF]
N. Giroux, C. Chau, H. Barbeau, T. A. Reader, and S. Rossignol
Effects of Intrathecal Glutamatergic Drugs on Locomotion. II. NMDA and AP-5 in Intact and Late Spinal Cats
J Neurophysiol, August 1, 2003; 90(2): 1027 - 1045.
[Abstract] [Full Text] [PDF]
S. Rossignol
Locomotion and its Recovery after Spinal Injury in Animal Models
Neurorehabil Neural Repair, June 1, 2002; 16(2): 201 - 206.
[PDF]
S. Yakovenko, V. Mushahwar, V. VanderHorst, G. Holstege, and A. Prochazka
Spatiotemporal Activation of Lumbosacral Motoneurons in the Locomotor Step Cycle
J Neurophysiol, March 1, 2002; 87(3): 1542 - 1553.
[Abstract] [Full Text] [PDF]
A. Berkowitz
Rhythmicity of Spinal Neurons Activated During Each Form of Fictive Scratching in Spinal Turtles
J Neurophysiol, August 1, 2001; 86(2): 1026 - 1036.
[Abstract] [Full Text] [PDF]
N. Giroux, T. A. Reader, and S. Rossignol
Comparison of the Effect of Intrathecal Administration of Clonidine and Yohimbine on the Locomotion of Intact and Spinal Cats
J Neurophysiol, June 1, 2001; 85(6): 2516 - 2536.
[Abstract] [Full Text] [PDF]
S Rossignol, N Giroux, C Chau, J Marcoux, E Brustein, and T A Reader
Pharmacological aids to locomotor training after spinal injury in the cat
J. Physiol., May 15, 2001; 533(1): 65 - 74.
[Abstract] [Full Text] [PDF]
A. Prochazka, V. K Mushahwar, and D. B McCreery
Neural prostheses
J. Physiol., May 15, 2001; 533(1): 99 - 109.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|