QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (38) Citing Articles via Google Scholar Google Scholar Articles by Mystkowski, P. Articles by Schwartz, M. W. Search for Related Content PubMed PubMed Citation Articles by Mystkowski, P. Articles by Schwartz, M. W.

 Previous Article  |  Next Article 

The Journal of Neuroscience, November 15, 2000, 20(22):8637-8642

Hypothalamic Melanin-Concentrating Hormone and Estrogen-Induced Weight Loss

Paul Mystkowski¹, Randy J. Seeley⁵, Tina M. Hahn¹, Denis G. Baskin¹, Peter J. Havel³, Alvin M. Matsumoto⁴, Charles W. Wilkinson^{2, 4}, Kimberly Peacock-Kinzig⁵, Kathleen A. Blake⁵, and Michael W. Schwartz¹

Departments of ¹ Medicine and ² Psychiatry and Behavioral Sciences, University of Washington and Veterans Affairs (VA) Puget Sound Health Care System, Seattle, Washington 98104, ³ Department of Nutrition, University of California at Davis, Davis, California 95616, ⁴ Geriatric Research/Education and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington, and ⁵ Department of Psychiatry, University of Cincinnati Medical Center, Cincinnati, Ohio 45267

Melanin-concentrating hormone (MCH) is an orexigenic neuropeptide produced by neurons of the lateral hypothalamic area (LHA). Because genetic MCH deficiency induces hypophagia and loss of body fat, we hypothesized that MCH neurons may represent a specific LHA pathway that, when inhibited, contributes to the pathogenesis of certain anorexia syndromes. To test this hypothesis, we measured behavioral, hormonal, and hypothalamic neuropeptide responses in two models of hyperestrogenemia in male rats, a highly reproducible anorexia paradigm. Whereas estrogen-induced weight loss engaged multiple systems that normally favor recovery of lost weight, the expected increase of MCH mRNA expression induced by energy restriction was selectively and completely abolished. These findings identify MCH neurons as specific targets of estrogen action and suggest that inhibition of these neurons may contribute to the hypophagic effect of estrogen.

Key words: MCH; estrogen; body weight; energy balance; lateral hypothalamus; anorexia; pair-feeding

---

Copyright © 2000 Society for Neuroscience  0270-6474/00/20228637-06$05.00/0

This article has been cited by other articles:

				C. Benedict, J. Scheller, S. Rose-John, J. Born, and L. Marshall Enhancing influence of intranasal interleukin-6 on slow-wave activity and memory consolidation during sleep FASEB J, October 1, 2009; 23(10): 3629 - 3636. [Abstract] [Full Text] [PDF]

				M. Lopez, C. J. Lelliott, S. Tovar, W. Kimber, R. Gallego, S. Virtue, M. Blount, M. J. Vazquez, N. Finer, T. J. Powles, et al. Tamoxifen-Induced Anorexia Is Associated With Fatty Acid Synthase Inhibition in the Ventromedial Nucleus of the Hypothalamus and Accumulation of Malonyl-CoA. Diabetes, May 1, 2006; 55(5): 1327 - 1336. [Abstract] [Full Text] [PDF]

				O. Fricke, G. Lehmkuhl, and D. W Pfaff Cybernetic principles in the systematic concept of hypothalamic feeding control Eur. J. Endocrinol., February 1, 2006; 154(2): 167 - 173. [Abstract] [Full Text] [PDF]

				C E de Rijke, J J G Hillebrand, L A W Verhagen, T A P Roeling, and R A H Adan Hypothalamic neuropeptide expression following chronic food restriction in sedentary and wheel-running rats J. Mol. Endocrinol., October 1, 2005; 35(2): 381 - 390. [Abstract] [Full Text] [PDF]

				X.-B. Gao, P. K. Ghosh, and A. N. van den Pol Neurons Synthesizing Melanin-Concentrating Hormone Identified by Selective Reporter Gene Expression After Transfection In Vitro: Transmitter Responses J Neurophysiol, December 1, 2003; 90(6): 3978 - 3985. [Abstract] [Full Text] [PDF]

				H. Zheng, M. Corkern, I. Stoyanova, L. M. Patterson, R. Tian, and H.-R. Berthoud Peptides that Regulate Food Intake: Appetite-inducing accumbens manipulation activates hypothalamic orexin neurons and inhibits POMC neurons Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2003; 284(6): R1436 - R1444. [Abstract] [Full Text] [PDF]

				A. Gomori, A. Ishihara, M. Ito, S. Mashiko, H. Matsushita, M. Yumoto, M. Ito, T. Tanaka, S. Tokita, M. Moriya, et al. Chronic intracerebroventricular infusion of MCH causes obesity in mice Am J Physiol Endocrinol Metab, March 1, 2003; 284(3): E583 - E588. [Abstract] [Full Text] [PDF]

				Y. Chen, C. Hu, C.-K. Hsu, Q. Zhang, C. Bi, M. Asnicar, H. M. Hsiung, N. Fox, L. J. Slieker, D. D. Yang, et al. Targeted Disruption of the Melanin-Concentrating Hormone Receptor-1 Results in Hyperphagia and Resistance to Diet-Induced Obesity Endocrinology, July 1, 2002; 143(7): 2469 - 2477. [Abstract] [Full Text] [PDF]

				E. Juttler, V. Tarabin, and M. Schwaninger Interleukin-6 (IL-6): A Possible Neuromodulator Induced by Neuronal Activity Neuroscientist, June 1, 2002; 8(3): 268 - 275. [Abstract] [PDF]

				H. Zheng, M. M. Corkern, S. M. Crousillac, L. M. Patterson, C. B. Phifer, and H.-R. Berthoud Neurochemical phenotype of hypothalamic neurons showing Fos expression 23 h after intracranial AgRP Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2002; 282(6): R1773 - R1781. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help