 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, December 1, 2000, 20(23):8853-8860
Impaired Recognition Memory in Rats after Damage to the Hippocampus
Robert E. Clark1, Stuart M. Zola1, 2, and Larry R. Squire1, 2 1 Veterans Affairs Medical Center, San Diego, California 92161, and 2 University of California San Diego, La Jolla, California 92093
Rats with radio-frequency or ibotenic acid lesions of the hippocampus and rats with radio-frequency lesions of the fornix were tested on the visual paired comparison task (VPC), a test of recognition memory. Memory was assessed at five different delay intervals ranging from 10 sec to 24 hr. All operated groups performed normally at the shorter delays (10 sec and 1 min). Across longer delays, the two groups with hippocampal damage were impaired. Rats with fornix lesions performed well on the VPC task but were impaired on a spatial task (spontaneous alternation). The results show that the hippocampus is essential for normal recognition memory. Moreover, fornix lesions need not mimic the effects of direct damage to hippocampal tissue. The findings are discussed in the context of the contribution of the hippocampus to recognition memory.
Key words: hippocampus; rats; visual paired comparison; fornix; ibotenic acid lesions; radio-frequency lesions; spontaneous alternation
Copyright © 2000 Society for Neuroscience 0270-6474/00/20238853-08$05.00/0
This article has been cited by other articles:
A. P. Weible, D. C. Rowland, R. Pang, and C. Kentros
Neural Correlates of Novel Object and Novel Location Recognition Behavior in the Mouse Anterior Cingulate Cortex
J Neurophysiol, October 1, 2009; 102(4): 2055 - 2068.
[Abstract] [Full Text] [PDF]
J. R. Manns and H. Eichenbaum
A cognitive map for object memory in the hippocampus
Learn. Mem., September 30, 2009; 16(10): 616 - 624.
[Abstract] [Full Text] [PDF]
P. Jaholkowski, A. Kiryk, P. Jedynak, N. M. Ben Abdallah, E. Knapska, A. Kowalczyk, A. Piechal, K. Blecharz-Klin, I. Figiel, V. Lioudyno, et al.
New hippocampal neurons are not obligatory for memory formation; cyclin D2 knockout mice with no adult brain neurogenesis show learning
Learn. Mem., June 24, 2009; 16(7): 439 - 451.
[Abstract] [Full Text] [PDF]
M. D. Crutcher, R. Calhoun-Haney, C. M. Manzanares, J. J. Lah, A. I. Levey, and S. M. Zola
Eye Tracking During a Visual Paired Comparison Task as a Predictor of Early Dementia
American Journal of Alzheimer's Disease and Other Dementias, June 1, 2009; 24(3): 258 - 266.
[Abstract] [PDF]
S. Jessberger, R. E. Clark, N. J. Broadbent, G. D. Clemenson Jr, A. Consiglio, D. C. Lie, L. R. Squire, and F. H. Gage
Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats
Learn. Mem., January 29, 2009; 16(2): 147 - 154.
[Abstract] [Full Text] [PDF]
P. Piterkin, E. Cole, M.-P. Cossette, S. Gaskin, and D. G. Mumby
A limited role for the hippocampus in the modulation of novel-object preference by contextual cues
Learn. Mem., October 2, 2008; 15(10): 785 - 791.
[Abstract] [Full Text] [PDF]
S. M. Fernandez, M. C. Lewis, A. S. Pechenino, L. L. Harburger, P. T. Orr, J. E. Gresack, G. E. Schafe, and K. M. Frick
Estradiol-Induced Enhancement of Object Memory Consolidation Involves Hippocampal Extracellular Signal-Regulated Kinase Activation and Membrane-Bound Estrogen Receptors
J. Neurosci., August 27, 2008; 28(35): 8660 - 8667.
[Abstract] [Full Text] [PDF]
M. D. White, M. Farmer, I. Mirabile, S. Brandner, J. Collinge, and G. R. Mallucci
Single treatment with RNAi against prion protein rescues early neuronal dysfunction and prolongs survival in mice with prion disease
PNAS, July 22, 2008; 105(29): 10238 - 10243.
[Abstract] [Full Text] [PDF]
M. L. Kalev-Zylinska and M. J. During
Paradoxical Facilitatory Effect of Low-Dose Alcohol Consumption on Memory Mediated by NMDA Receptors
J. Neurosci., September 26, 2007; 27(39): 10456 - 10467.
[Abstract] [Full Text] [PDF]
D. Ferguson and R. Sapolsky
Mineralocorticoid Receptor Overexpression Differentially Modulates Specific Phases of Spatial and Nonspatial Memory
J. Neurosci., July 25, 2007; 27(30): 8046 - 8052.
[Abstract] [Full Text] [PDF]
R. E. Clark, N. J. Broadbent, and L. R. Squire
The Hippocampus and Spatial Memory: Findings with a Novel Modification of the Water Maze
J. Neurosci., June 20, 2007; 27(25): 6647 - 6654.
[Abstract] [Full Text] [PDF]
S. Jessberger, K. Nakashima, G. D. Clemenson Jr, E. Mejia, E. Mathews, K. Ure, S. Ogawa, C. M. Sinton, F. H. Gage, and J. Hsieh
Epigenetic Modulation of Seizure-Induced Neurogenesis and Cognitive Decline
J. Neurosci., May 30, 2007; 27(22): 5967 - 5975.
[Abstract] [Full Text] [PDF]
N. J. Broadbent, L. R. Squire, and R. E. Clark
Rats depend on habit memory for discrimination learning and retention
Learn. Mem., March 8, 2007; 14(3): 145 - 151.
[Abstract] [Full Text] [PDF]
A. E. Moseley, M. T. Williams, T. L. Schaefer, C. S. Bohanan, J. C. Neumann, M. M. Behbehani, C. V. Vorhees, and J. B Lingrel
Deficiency in Na,K-ATPase {alpha} Isoform Genes Alters Spatial Learning, Motor Activity, and Anxiety in Mice
J. Neurosci., January 17, 2007; 27(3): 616 - 626.
[Abstract] [Full Text] [PDF]
J. I. Rossato, L. R.M. Bevilaqua, J. C. Myskiw, J. H. Medina, I. Izquierdo, and M. Cammarota
On the role of hippocampal protein synthesis in the consolidation and reconsolidation of object recognition memory
Learn. Mem., January 1, 2007; 14(1-2): 36 - 46.
[Abstract] [Full Text] [PDF]
L. M. Saksida, T. J. Bussey, C. A. Buckmaster, and E. A. Murray
Impairment and Facilitation of Transverse Patterning after Lesions of the Perirhinal Cortex and Hippocampus, Respectively
Cereb Cortex, January 1, 2007; 17(1): 108 - 115.
[Abstract] [Full Text] [PDF]
J. C. Jackson, A. Johnson, and A. D. Redish
Hippocampal Sharp Waves and Reactivation during Awake States Depend on Repeated Sequential Experience
J. Neurosci., November 29, 2006; 26(48): 12415 - 12426.
[Abstract] [Full Text] [PDF]
L. G. Reijmers, J. K. Coats, M. T. Pletcher, T. Wiltshire, L. M. Tarantino, and M. Mayford
A mutant mouse with a highly specific contextual fear-conditioning deficit found in an N-ethyl-N-nitrosourea (ENU) mutagenesis screen.
Learn. Mem., March 1, 2006; 13(2): 143 - 149.
[Abstract] [Full Text] [PDF]
K. L. Brunson, E. Kramar, B. Lin, Y. Chen, L. L. Colgin, T. K. Yanagihara, G. Lynch, and T. Z. Baram
Mechanisms of Late-Onset Cognitive Decline after Early-Life Stress
J. Neurosci., October 12, 2005; 25(41): 9328 - 9338.
[Abstract] [Full Text] [PDF]
C. Venero, A. Guadano-Ferraz, A. I. Herrero, K. Nordstrom, J. Manzano, G. M. de Escobar, J. Bernal, and B. Vennstrom
Anxiety, memory impairment, and locomotor dysfunction caused by a mutant thyroid hormone receptor {alpha}1 can be ameliorated by T3 treatment
Genes & Dev., September 15, 2005; 19(18): 2152 - 2163.
[Abstract] [Full Text] [PDF]
K. A. Fenoglio, K. L. Brunson, S. Avishai-Eliner, B. A. Stone, B. J. Kapadia, and T. Z. Baram
Enduring, Handling-Evoked Enhancement of Hippocampal Memory Function and Glucocorticoid Receptor Expression Involves Activation of the Corticotropin-Releasing Factor Type 1 Receptor
Endocrinology, September 1, 2005; 146(9): 4090 - 4096.
[Abstract] [Full Text] [PDF]
M. Wietrzych, H. Meziane, A. Sutter, N. Ghyselinck, P. F. Chapman, P. Chambon, and W. Krezel
Working memory deficits in retinoid X receptor {gamma}-deficient mice
Learn. Mem., May 1, 2005; 12(3): 318 - 326.
[Abstract] [Full Text] [PDF]
B. D. Winters and T. J. Bussey
Transient Inactivation of Perirhinal Cortex Disrupts Encoding, Retrieval, and Consolidation of Object Recognition Memory
J. Neurosci., January 5, 2005; 25(1): 52 - 61.
[Abstract] [Full Text] [PDF]
K. Limback-Stokin, E. Korzus, R. Nagaoka-Yasuda, and M. Mayford
Nuclear Calcium/Calmodulin Regulates Memory Consolidation
J. Neurosci., December 1, 2004; 24(48): 10858 - 10867.
[Abstract] [Full Text] [PDF]
N. J. Broadbent, L. R. Squire, and R. E. Clark
Spatial memory, recognition memory, and the hippocampus
PNAS, October 5, 2004; 101(40): 14515 - 14520.
[Abstract] [Full Text] [PDF]
B. D. Winters, S. E. Forwood, R. A. Cowell, L. M. Saksida, and T. J. Bussey
Double Dissociation between the Effects of Peri-Postrhinal Cortex and Hippocampal Lesions on Tests of Object Recognition and Spatial Memory: Heterogeneity of Function within the Temporal Lobe
J. Neurosci., June 30, 2004; 24(26): 5901 - 5908.
[Abstract] [Full Text] [PDF]
G. T. Prusky, R. M. Douglas, L. Nelson, A. Shabanpoor, and R. J. Sutherland
Visual memory task for rats reveals an essential role for hippocampus and perirhinal cortex
PNAS, April 6, 2004; 101(14): 5064 - 5068.
[Abstract] [Full Text] [PDF]
S. Nemanic, M. C. Alvarado, and J. Bachevalier
The Hippocampal/Parahippocampal Regions and Recognition Memory: Insights from Visual Paired Comparison versus Object-Delayed Nonmatching in Monkeys
J. Neurosci., February 25, 2004; 24(8): 2013 - 2026.
[Abstract] [Full Text] [PDF]
S. G. Coleshill, C. D. Binnie, R. G. Morris, G. Alarcon, W. van Emde Boas, D. N. Velis, A. Simmons, C. E. Polkey, C. W. M. van Veelen, and P. C. van Rijen
Material-Specific Recognition Memory Deficits Elicited by Unilateral Hippocampal Electrical Stimulation
J. Neurosci., February 18, 2004; 24(7): 1612 - 1616.
[Abstract] [Full Text] [PDF]
S. Okuda, B. Roozendaal, and J. L. McGaugh
Glucocorticoid effects on object recognition memory require training-associated emotional arousal
PNAS, January 20, 2004; 101(3): 853 - 858.
[Abstract] [Full Text] [PDF]
T. Tzounopoulos and R. Stackman
Enhancing Synaptic Plasticity and Memory: A Role for Small-Conductance Ca2+-Activated K+ Channels
Neuroscientist, December 1, 2003; 9(6): 434 - 439.
[Abstract] [PDF]
A. Kelly, S. Laroche, and S. Davis
Activation of Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase in Hippocampal Circuitry Is Required for Consolidation and Reconsolidation of Recognition Memory
J. Neurosci., June 15, 2003; 23(12): 5354 - 5360.
[Abstract] [Full Text] [PDF]
L. Davachi, J. P. Mitchell, and A. D. Wagner
Multiple routes to memory: Distinct medial temporal lobe processes build item and source memories
PNAS, February 18, 2003; 100(4): 2157 - 2162.
[Abstract] [Full Text] [PDF]
R. W. Stackman, R. S. Hammond, E. Linardatos, A. Gerlach, J. Maylie, J. P. Adelman, and T. Tzounopoulos
Small Conductance Ca2+-Activated K+ Channels Modulate Synaptic Plasticity and Memory Encoding
J. Neurosci., December 1, 2002; 22(23): 10163 - 10171.
[Abstract] [Full Text] [PDF]
R. E. Clark, N. J. Broadbent, S. M. Zola, and L. R. Squire
Anterograde Amnesia and Temporally Graded Retrograde Amnesia for a Nonspatial Memory Task after Lesions of Hippocampus and Subiculum
J. Neurosci., June 1, 2002; 22(11): 4663 - 4669.
[Abstract] [Full Text] [PDF]
D. G. Mumby, S. Gaskin, M. J. Glenn, T. E. Schramek, and H. Lehmann
Hippocampal Damage and Exploratory Preferences in Rats: Memory for Objects, Places, and Contexts
Learn. Mem., March 1, 2002; 9(2): 49 - 57.
[Abstract] [Full Text] [PDF]
K. B. Baker and J. J. Kim
Effects of Stress and Hippocampal NMDA Receptor Antagonism on Recognition Memory in Rats
Learn. Mem., March 1, 2002; 9(2): 58 - 65.
[Abstract] [Full Text] [PDF]
L. R. Squire, H. Schmolck, and S. M. Stark
Impaired Auditory Recognition Memory in Amnesic Patients with Medial Temporal Lobe Lesions
Learn. Mem., September 1, 2001; 8(5): 252 - 256.
[Abstract] [Full Text] [PDF]
K. L. Brunson, M. Eghbal-Ahmadi, R. Bender, Y. Chen, and T. Z. Baram
Long-term, progressive hippocampal cell loss and dysfunction induced by early-life administration of corticotropin-releasing hormone reproduce the effects of early-life stress
PNAS, July 5, 2001; (2001) 151224898.
[Abstract] [Full Text] [PDF]
S. A. Hollup, K. G. Kjelstrup, J. Hoff, M.-B. Moser, and E. I. Moser
Impaired Recognition of the Goal Location during Spatial Navigation in Rats with Hippocampal Lesions
J. Neurosci., June 15, 2001; 21(12): 4505 - 4513.
[Abstract] [Full Text] [PDF]
K. L. Brunson, M. Eghbal-Ahmadi, R. Bender, Y. Chen, and T. Z. Baram
Long-term, progressive hippocampal cell loss and dysfunction induced by early-life administration of corticotropin-releasing hormone reproduce the effects of early-life stress
PNAS, July 17, 2001; 98(15): 8856 - 8861.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|