 |
 Previous Article | Next Article 
The Journal of Neuroscience, December 15, 2000, 20(24):9104-9110
Chronic Antidepressant Treatment Increases Neurogenesis in Adult
Rat Hippocampus
Jessica E.
Malberg,
Amelia J.
Eisch,
Eric J.
Nestler, and
Ronald S.
Duman
Laboratory of Molecular Psychiatry, Departments of Psychiatry and
Pharmacology, Yale University School of Medicine, Connecticut Mental
Health Center, New Haven, Connecticut 06508
Recent studies suggest that stress-induced atrophy and loss of
hippocampal neurons may contribute to the pathophysiology of depression. The aim of this study was to investigate the effect of
antidepressants on hippocampal neurogenesis in the adult rat, using the
thymidine analog bromodeoxyuridine (BrdU) as a marker for dividing
cells. Our studies demonstrate that chronic antidepressant treatment
significantly increases the number of BrdU-labeled cells in the dentate
gyrus and hilus of the hippocampus. Administration of several different
classes of antidepressant, but not non-antidepressant, agents was found
to increase BrdU-labeled cell number, indicating that this is a common
and selective action of antidepressants. In addition, upregulation of
the number of BrdU-labeled cells is observed after chronic, but not
acute, treatment, consistent with the time course for the therapeutic
action of antidepressants. Additional studies demonstrated that
antidepressant treatment increases the proliferation of hippocampal
cells and that these new cells mature and become neurons, as determined
by triple labeling for BrdU and neuronal- or glial-specific markers.
These findings raise the possibility that increased cell proliferation
and increased neuronal number may be a mechanism by which
antidepressant treatment overcomes the stress-induced atrophy and loss
of hippocampal neurons and may contribute to the therapeutic actions of
antidepressant treatment.
Key words:
proliferation; granule cell; fluoxetine; tranylcypromine; reboxetine; depression
Copyright © 2000 Society for Neuroscience 0270-6474/00/20249104-07$05.00/0
This article has been cited by other articles:
|
|
|
|
 
J.-S. Lee, D.-J. Jang, N. Lee, H.-G. Ko, H. Kim, Y.-S. Kim, B. Kim, J. Son, S. H. Kim, H. Chung, et al.
Induction of Neuronal Vascular Endothelial Growth Factor Expression by cAMP in the Dentate Gyrus of the Hippocampus Is Required for Antidepressant-Like Behaviors
J. Neurosci.,
July 1, 2009;
29(26):
8493 - 8505.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K Pennington, M Focking, C. McManus, C. Pariante, M. Dunn, and D. Cotter
A proteomic investigation of similarities between conventional and herbal antidepressant treatments
J Psychopharmacol,
July 1, 2009;
23(5):
520 - 530.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J. A. Perez, S. M. Clinton, C. A. Turner, S. J. Watson, and H. Akil
A New Role for FGF2 as an Endogenous Inhibitor of Anxiety
J. Neurosci.,
May 13, 2009;
29(19):
6379 - 6387.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L Dahan, H Husum, O Mnie-Filali, J Arnt, P Hertel, and N Haddjeri
Effects of bifeprunox and aripiprazole on rat serotonin and dopamine neuronal activity and anxiolytic behaviour
J Psychopharmacol,
March 1, 2009;
23(2):
177 - 189.
[Abstract]
[PDF]
|
|
|
|
|
|
|
A. J. Eisch, H. A. Cameron, J. M. Encinas, L. A. Meltzer, G.-L. Ming, and L. S. Overstreet-Wadiche
Adult Neurogenesis, Mental Health, and Mental Illness: Hope or Hype?
J. Neurosci.,
November 12, 2008;
28(46):
11785 - 11791.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Labasque, E. Reiter, C. Becamel, J. Bockaert, and P. Marin
Physical Interaction of Calmodulin with the 5-Hydroxytryptamine2C Receptor C-Terminus Is Essential for G Protein-independent, Arrestin-dependent Receptor Signaling
Mol. Biol. Cell,
November 1, 2008;
19(11):
4640 - 4650.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. A. Lieberman, F. P. Bymaster, H. Y. Meltzer, A. Y. Deutch, G. E. Duncan, C. E. Marx, J. R. Aprille, D. S. Dwyer, X.-M. Li, S. P. Mahadik, et al.
Antipsychotic Drugs: Comparison in Animal Models of Efficacy, Neurotransmitter Regulation, and Neuroprotection
Pharmacol. Rev.,
September 1, 2008;
60(3):
358 - 403.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Segi-Nishida, J. L. Warner-Schmidt, and R. S. Duman
Electroconvulsive seizure and VEGF increase the proliferation of neural stem-like cells in rat hippocampus
PNAS,
August 12, 2008;
105(32):
11352 - 11357.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. D. Perera, S. Park, and Y. Nemirovskaya
Cognitive Role of Neurogenesis in Depression and Antidepressant Treatment
Neuroscientist,
August 1, 2008;
14(4):
326 - 338.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J. C. Garza, M. Guo, W. Zhang, and X.-Y. Lu
Leptin Increases Adult Hippocampal Neurogenesis in Vivo and in Vitro
J. Biol. Chem.,
June 27, 2008;
283(26):
18238 - 18247.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Kobayashi, Y. Ikeda, E. Haneda, and H. Suzuki
Chronic Fluoxetine Bidirectionally Modulates Potentiating Effects of Serotonin on the Hippocampal Mossy Fiber Synaptic Transmission
J. Neurosci.,
June 11, 2008;
28(24):
6272 - 6280.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. E. Malberg and L. M. Monteggia
VGF, a New Player in Antidepressant Action?
Sci. Signal.,
May 6, 2008;
1(18):
pe19 - pe19.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. F. M. Vetencourt, A. Sale, A. Viegi, L. Baroncelli, R. De Pasquale, O. F. O'Leary, E. Castren, and L. Maffei
The Antidepressant Fluoxetine Restores Plasticity in the Adult Visual Cortex
Science,
April 18, 2008;
320(5874):
385 - 388.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. O'Reilly, S. J. Bailey, and M. A. Lane
Retinoid-Mediated Regulation of Mood: Possible Cellular Mechanisms
Experimental Biology and Medicine,
March 1, 2008;
233(3):
251 - 258.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. A. Cunningham and C. S. Watson
Cell cycle regulation, neurogenesis, and depression
PNAS,
February 19, 2008;
105(7):
2259 - 2260.
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-W. Wang, D. J. David, J. E. Monckton, F. Battaglia, and R. Hen
Chronic Fluoxetine Stimulates Maturation and Synaptic Plasticity of Adult-Born Hippocampal Granule Cells
J. Neurosci.,
February 6, 2008;
28(6):
1374 - 1384.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. N. Pechnick, S. Zonis, K. Wawrowsky, J. Pourmorady, and V. Chesnokova
p21Cip1 restricts neuronal proliferation in the subgranular zone of the dentate gyrus of the hippocampus
PNAS,
January 29, 2008;
105(4):
1358 - 1363.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Thakker-Varia, J. J. Krol, J. Nettleton, P. M. Bilimoria, D. A. Bangasser, T. J. Shors, I. B. Black, and J. Alder
The Neuropeptide VGF Produces Antidepressant-Like Behavioral Effects and Enhances Proliferation in the Hippocampus
J. Neurosci.,
November 7, 2007;
27(45):
12156 - 12167.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. R. Bambico, N. Katz, G. Debonnel, and G. Gobbi
Cannabinoids Elicit Antidepressant-Like Behavior and Activate Serotonergic Neurons through the Medial Prefrontal Cortex
J. Neurosci.,
October 24, 2007;
27(43):
11700 - 11711.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Leuner, Y. Kozorovitskiy, C. G. Gross, and E. Gould
Diminished adult neurogenesis in the marmoset brain precedes old age
PNAS,
October 23, 2007;
104(43):
17169 - 17173.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. C. Whitman and C. A. Greer
Synaptic Integration of Adult-Generated Olfactory Bulb Granule Cells: Basal Axodendritic Centrifugal Input Precedes Apical Dendrodendritic Local Circuits
J. Neurosci.,
September 12, 2007;
27(37):
9951 - 9961.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T.-Y. Eom, K. A. Roth, and R. S. Jope
Neural Precursor Cells Are Protected from Apoptosis Induced by Trophic Factor Withdrawal or Genotoxic Stress by Inhibitors of Glycogen Synthase Kinase 3
J. Biol. Chem.,
August 3, 2007;
282(31):
22856 - 22864.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. L. Gur, A. C. Conti, J. Holden, A. J. Bechtholt, T. E. Hill, I. Lucki, J. E. Malberg, and J. A. Blendy
cAMP Response Element-Binding Protein Deficiency Allows for Increased Neurogenesis and a Rapid Onset of Antidepressant Response
J. Neurosci.,
July 18, 2007;
27(29):
7860 - 7868.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. D. Perera, J. D. Coplan, S. H. Lisanby, C. M. Lipira, M. Arif, C. Carpio, G. Spitzer, L. Santarelli, B. Scharf, R. Hen, et al.
Antidepressant-Induced Neurogenesis in the Hippocampus of Adult Nonhuman Primates
J. Neurosci.,
May 2, 2007;
27(18):
4894 - 4901.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. J. David, K. C. Klemenhagen, K. A. Holick, M. D. Saxe, I. Mendez, L. Santarelli, D. A. Craig, H. Zhong, C. J. Swanson, L. G. Hegde, et al.
Efficacy of the MCHR1 Antagonist N-[3-(1-{[4-(3,4-Difluorophenoxy)phenyl]methyl}(4-piperidyl))-4-methylphenyl]-2-methylpropanamide (SNAP 94847) in Mouse Models of Anxiety and Depression following Acute and Chronic Administration Is Independent of Hippocampal Neurogenesis
J. Pharmacol. Exp. Ther.,
April 1, 2007;
321(1):
237 - 248.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. L. Warner-Schmidt and R. S. Duman
VEGF is an essential mediator of the neurogenic and behavioral actions of antidepressants
PNAS,
March 13, 2007;
104(11):
4647 - 4652.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Duric and K. E. McCarson
Effects of Analgesic or Antidepressant Drugs on Pain- or Stress-Evoked Hippocampal and Spinal Neurokinin-1 Receptor and Brain-Derived Neurotrophic Factor Gene Expression in the Rat
J. Pharmacol. Exp. Ther.,
December 1, 2006;
319(3):
1235 - 1243.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Shankaran, C. King, J. Lee, R. Busch, M. Wolff, and M. K. Hellerstein
Discovery of Novel Hippocampal Neurogenic Agents by Using an in Vivo Stable Isotope Labeling Technique
J. Pharmacol. Exp. Ther.,
December 1, 2006;
319(3):
1172 - 1181.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
U Shivraj Sohur, J. G Emsley, B. D Mitchell, and J. D Macklis
Adult neurogenesis and cellular brain repair with neural progenitors, precursors and stem cells
Phil Trans R Soc B,
September 29, 2006;
361(1473):
1477 - 1497.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-M. Launay, B. Schneider, S. Loric, M. Da Prada, and O. Kellermann
Serotonin transport and serotonin transporter-mediated antidepressant recognition are controlled by 5-HT2B receptor signaling in serotonergic neuronal cells
FASEB J,
September 1, 2006;
20(11):
1843 - 1854.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Tachibana, M. Matsumoto, H. Koseki, H. Togashi, T. Kojima, Y. Morimoto, and M. Yoshioka
Electrophysiological and neurochemical characterization of the effect of repeated treatment with milnacipran on the rat serotonergic and noradrenergic systems
J Psychopharmacol,
July 1, 2006;
20(4):
562 - 569.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J. M. Encinas, A. Vaahtokari, and G. Enikolopov
Fluoxetine targets early progenitor cells in the adult brain
PNAS,
May 23, 2006;
103(21):
8233 - 8238.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Vermetten, C. Schmahl, S. Lindner, R. J. Loewenstein, and J. D. Bremner
Hippocampal and Amygdalar Volumes in Dissociative Identity Disorder
Am J Psychiatry,
April 1, 2006;
163(4):
630 - 636.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Hajszan and N. J. MacLusky
Neurologic links between epilepsy and depression in women: Is hippocampal neuroplasticity the key?
Neurology,
March 28, 2006;
66(66_suppl_3):
S13 - S22.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
S. A. Ferguson, F. J. Cisneros, B. Gough, J. P. Hanig, and K. J. Berry
Chronic Oral Treatment with 13-cis-Retinoic Acid (Isotretinoin) or all-trans-Retinoic Acid Does Not Alter Depression-Like Behaviors in Rats
Toxicol. Sci.,
October 1, 2005;
87(2):
451 - 459.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. B. Ngwenya, A. Peters, and D. L. Rosene
Light and Electron Microscopic Immunohistochemical Detection of Bromodeoxyuridine-labeled Cells in the Brain: Different Fixation and Processing Protocols
J. Histochem. Cytochem.,
July 1, 2005;
53(7):
821 - 832.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. E. Kippin, S. Kapur, and D. van der Kooy
Dopamine Specifically Inhibits Forebrain Neural Stem Cell Proliferation, Suggesting a Novel Effect of Antipsychotic Drugs
J. Neurosci.,
June 15, 2005;
25(24):
5815 - 5823.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. N. Abrous, M. Koehl, and M. Le Moal
Adult Neurogenesis: From Precursors to Network and Physiology
Physiol Rev,
April 1, 2005;
85(2):
523 - 569.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. D. Bremner, T. Mletzko, S. Welter, S. Quinn, C. Williams, M. Brummer, S. Siddiq, L. Reed, C. M. Heim, and C. B. Nemeroff
Effects of phenytoin on memory, cognition and brain structure in post-traumatic stress disorder: a pilot study
J Psychopharmacol,
March 1, 2005;
19(2):
159 - 165.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M. Sairanen, G. Lucas, P. Ernfors, M. Castren, and E. Castren
Brain-Derived Neurotrophic Factor and Antidepressant Drugs Have Different But Coordinated Effects on Neuronal Turnover, Proliferation, and Survival in the Adult Dentate Gyrus
J. Neurosci.,
February 2, 2005;
25(5):
1089 - 1094.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. M. MacQueen, S. Campbell, B. S. McEwen, K. Macdonald, S. Amano, R. T. Joffe, C. Nahmias, and L. T. Young
Course of Illness, Hippocampal Function, and Hippocampal Volume in Major Depression
Focus,
January 1, 2005;
3(1):
146 - 155.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. G. Kuhn, C. Cooper-Kuhn, P. Eriksson, and M. Nilsson
Signals Regulating Neurogenesis in the Adult Olfactory Bulb
Chem Senses,
January 1, 2005;
30(suppl_1):
i109 - i110.
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. R. Albert and S. Lemonde
5-HT1A Receptors, Gene Repression, and Depression: Guilt by Association
Neuroscientist,
December 1, 2004;
10(6):
575 - 593.
[Abstract]
[PDF]
|
|
|
|
|
|
|
A. Kowalczyk, R. K. Filipkowski, M. Rylski, G. M. Wilczynski, F. A. Konopacki, J. Jaworski, M. A. Ciemerych, P. Sicinski, and L. Kaczmarek
The critical role of cyclin D2 in adult neurogenesis
J. Cell Biol.,
October 25, 2004;
167(2):
209 - 213.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Mey and P. Mccaffery
Retinoic Acid Signaling in the Nervous System of Adult Vertebrates
Neuroscientist,
October 1, 2004;
10(5):
409 - 421.
[Abstract]
[PDF]
|
|
|
|
|
|
|
P. Monteleone, A. Tortorella, V. Martiadis, C. Serritella, A. Fuschino, and M. Maj
Opposite Changes in the Serum Brain-Derived Neurotrophic Factor in Anorexia Nervosa and Obesity
Psychosom Med,
September 1, 2004;
66(5):
744 - 748.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Hao, T. Creson, L. Zhang, P. Li, F. Du, P. Yuan, T. D. Gould, H. K. Manji, and G. Chen
Mood Stabilizer Valproate Promotes ERK Pathway-Dependent Cortical Neuronal Growth and Neurogenesis
J. Neurosci.,
July 21, 2004;
24(29):
6590 - 6599.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Y. Zhu, L. Lau, S. H. Liu, J. S. Wei, and Y. M. Lu
Activation of cAMP-response-element-binding protein (CREB) after focal cerebral ischemia stimulates neurogenesis in the adult dentate gyrus
PNAS,
June 22, 2004;
101(25):
9453 - 9457.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Crandall, Y. Sakai, J. Zhang, O. Koul, Y. Mineur, W. E. Crusio, and P. McCaffery
13-cis-retinoic acid suppresses hippocampal cell division and hippocampal-dependent learning in mice
PNAS,
April 6, 2004;
101(14):
5111 - 5116.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Campbell, M. Marriott, C. Nahmias, and G. M. MacQueen
Lower Hippocampal Volume in Patients Suffering From Depression: A Meta-Analysis
Am J Psychiatry,
April 1, 2004;
161(4):
598 - 607.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Fujioka, A. Fujioka, and R. S. Duman
Activation of cAMP Signaling Facilitates the Morphological Maturation of Newborn Neurons in Adult Hippocampus
J. Neurosci.,
January 14, 2004;
24(2):
319 - 328.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. J. Shors
Can New Neurons Replace Memories Lost?
Sci. Aging Knowl. Environ.,
December 10, 2003;
2003(49):
pe35 - 35.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
R. S. Wilson, D. A. Evans, J. L. Bienias, C. F. Mendes de Leon, J. A. Schneider, and D. A. Bennett
Proneness to psychological distress is associated with risk of Alzheimer's disease
Neurology,
December 9, 2003;
61(11):
1479 - 1485.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. M. Thomas and D. A. Peterson
A Neurogenic Theory of Depression Gains Momentum
Mol. Interv.,
December 1, 2003;
3(8):
441 - 444.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. S. Newton, E. F. Collier, J. Hunsberger, D. Adams, R. Terwilliger, E. Selvanayagam, and R. S. Duman
Gene Profile of Electroconvulsive Seizures: Induction of Neurotrophic and Angiogenic Factors
J. Neurosci.,
November 26, 2003;
23(34):
10841 - 10851.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Santarelli, M. Saxe, C. Gross, A. Surget, F. Battaglia, S. Dulawa, N. Weisstaub, J. Lee, R. Duman, O. Arancio, et al.
Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants
Science,
August 8, 2003;
301(5634):
805 - 809.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. guzman-marin, N. Suntsova, D. R Stewart, H. Gong, R. Szymusiak, and D. McGinty
Sleep deprivation reduces proliferation of cells in the dentate gyrus of the hippocampus in rats
J. Physiol.,
June 1, 2003;
549(2):
563 - 571.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. F. Deicken, M. P. Pegues, S. Anzalone, R. Feiwell, and B. Soher
Lower Concentration of Hippocampal N-Acetylaspartate in Familial Bipolar I Disorder
Am J Psychiatry,
May 1, 2003;
160(5):
873 - 882.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. D. Bremner, M. Vythilingam, E. Vermetten, S. M. Southwick, T. McGlashan, A. Nazeer, S. Khan, L. V. Vaccarino, R. Soufer, P. K. Garg, et al.
MRI and PET Study of Deficits in Hippocampal Structure and Function in Women With Childhood Sexual Abuse and Posttraumatic Stress Disorder
Am J Psychiatry,
May 1, 2003;
160(5):
924 - 932.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Dong, C. A. Csernansky, B. Goico, and J. G. Csernansky
Hippocampal Neurogenesis Follows Kainic Acid-Induced Apoptosis in Neonatal Rats
J. Neurosci.,
March 1, 2003;
23(5):
1742 - 1749.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. M. MacQueen, S. Campbell, B. S. McEwen, K. Macdonald, S. Amano, R. T. Joffe, C. Nahmias, and L. T. Young
Course of illness, hippocampal function, and hippocampal volume in major depression
PNAS,
February 4, 2003;
100(3):
1387 - 1392.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Chardenot, C. Roubert, S. Galiegue, P. Casellas, G. Le Fur, P. Soubrie, and F. Oury-Donat
Expression Profile and Up-Regulation of Prax-1 mRNA by Antidepressant Treatment in the Rat Brain
Mol. Pharmacol.,
December 1, 2002;
62(6):
1314 - 1320.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Nakagawa, J.-E. Kim, R. Lee, J. Chen, T. Fujioka, J. Malberg, S. Tsuji, and R. S. Duman
Localization of Phosphorylated cAMP Response Element-Binding Protein in Immature Neurons of Adult Hippocampus
J. Neurosci.,
November 15, 2002;
22(22):
9868 - 9876.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Meng and P. J. Casey
Activation of Gz Attenuates Rap1-mediated Differentiation of PC12 Cells
J. Biol. Chem.,
November 1, 2002;
277(45):
43417 - 43424.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. P. Mattson, S. L. Chan, and W. Duan
Modification of Brain Aging and Neurodegenerative Disorders by Genes, Diet, and Behavior
Physiol Rev,
July 1, 2002;
82(3):
637 - 672.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Nakagawa, J.-E. Kim, R. Lee, J. E. Malberg, J. Chen, C. Steffen, Y.-J. Zhang, E. J. Nestler, and R. S. Duman
Regulation of Neurogenesis in Adult Mouse Hippocampus by cAMP and the cAMP Response Element-Binding Protein
J. Neurosci.,
May 1, 2002;
22(9):
3673 - 3682.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Mallei, B. Shi, and I. Mocchetti
Antidepressant Treatments Induce the Expression of Basic Fibroblast Growth Factor in Cortical and Hippocampal Neurons
Mol. Pharmacol.,
May 1, 2002;
61(5):
1017 - 1024.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. C. Conti, J. F. Cryan, A. Dalvi, I. Lucki, and J. A. Blendy
cAMP Response Element-Binding Protein Is Essential for the Upregulation of Brain-Derived Neurotrophic Factor Transcription, But Not the Behavioral or Endocrine Responses to Antidepressant Drugs
J. Neurosci.,
April 15, 2002;
22(8):
3262 - 3268.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. M. Oldham
A 44-Year-Old Woman With Borderline Personality Disorder
JAMA,
February 27, 2002;
287(8):
1029 - 1037.
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. RIMONDINI, C. ARLINDE, W. SOMMER, and M. HEILIG
Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol
FASEB J,
January 1, 2002;
16(1):
27 - 35.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. S. Duman, J. Malberg, and S. Nakagawa
Regulation of Adult Neurogenesis by Psychotropic Drugs and Stress
J. Pharmacol. Exp. Ther.,
November 1, 2001;
299(2):
401 - 407.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. M. Sapolsky
Depression, antidepressants, and the shrinking hippocampus
PNAS,
October 23, 2001;
98(22):
12320 - 12322.
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Czeh, T. Michaelis, T. Watanabe, J. Frahm, G. de Biurrun, M. van Kampen, A. Bartolomucci, and E. Fuchs
Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine
PNAS,
September 26, 2001;
(2001)
211427898.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. A Vaidya and R. S Duman
Depression - emerging insights from neurobiology
Br. Med. Bull.,
March 1, 2001;
57(1):
61 - 79.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Czeh, T. Michaelis, T. Watanabe, J. Frahm, G. de Biurrun, M. van Kampen, A. Bartolomucci, and E. Fuchs
Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine
PNAS,
October 23, 2001;
98(22):
12796 - 12801.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
