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The Journal of Neuroscience, February 15, 2000, 20(4):1550-1558
-Melanocyte-Stimulating Hormone Is Contained in Nerve Terminals Innervating Thyrotropin-Releasing Hormone-Synthesizing Neurons in the Hypothalamic Paraventricular Nucleus and Prevents Fasting-Induced Suppression of Prothyrotropin-Releasing Hormone Gene Expression
Csaba Fekete1, 2, Gábor Légrádi1, Emese Mihály1, Qin-Heng Huang1, Jeffrey B. Tatro1, William M. Rand3, Charles H. Emerson4, and Ronald M. Lechan1, 5 1 Tupper Research Institute and Department of Medicine, Division of Endocrinology, Diabetes, Metabolism, and Molecular Medicine, New England Medical Center, Boston, Massachusetts 02111, 2 Department of Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary, 3 Department of Community Health, Tufts University School of Medicine, Boston, Massachusetts 02111, 4 Department of Medicine, Division of Endocrinology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, and 5 Department of Neuroscience, Tufts University School of Medicine, Boston, Massachusetts 02111
The hypothalamic arcuate nucleus has an essential role in mediating the homeostatic responses of the thyroid axis to fasting by altering the sensitivity of prothyrotropin-releasing hormone (pro-TRH) gene expression in the paraventricular nucleus (PVN) to feedback regulation by thyroid hormone. Because agouti-related protein (AGRP), a leptin-regulated, arcuate nucleus-derived peptide with
-MSH antagonist activity, is contained in axon terminals that terminate on TRH neurons in the PVN, we raised the possibility that
Key words: thyrotropin-releasing hormone; thyroid axis;
Copyright © 2000 Society for Neuroscience 0270-6474/00/2041550-09$05.00/0
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[Abstract] [Full Text] [PDF]
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[Abstract] [Full Text] [PDF]
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[Abstract] [Full Text]
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[Abstract] [Full Text] [PDF]
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