 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, March 15, 2000, 20(6):2255-2265
Acute Changes in Maternal Thyroid Hormone Induce Rapid and Transient Changes in Gene Expression in Fetal Rat Brain
Amy L. S. Dowling1, Gabriel U. Martz1, Jack L. Leonard2, and R. Thomas Zoeller1 1 Biology Department and Molecular and Cellular Biology Program, University of Massachusetts, Amherst, Massachusetts 01003, and 2 Molecular Endocrinology Laboratory, University of Massachusetts Medical School, Worcester, Massachusetts 01655
Despite clinical evidence that thyroid hormone is essential for brain development before birth, effects of thyroid hormone on the fetal brain have been largely unexplored. One mechanism of thyroid hormone action is regulation of gene expression, because thyroid hormone receptors (TRs) are ligand-activated transcription factors. We used differential display to identify genes affected by acute T4 administration to the dam before the onset of fetal thyroid function. Eight of the 11 genes that we identified were selectively expressed in brain areas known to contain TRs, indicating that these genes were directly regulated by thyroid hormone. Using in situ hybridization, we confirmed that the cortical expression of both neuroendocrine-specific protein (NSP) and Oct-1 was affected by changes in maternal thyroid status. Additionally, we demonstrated that both NSP and Oct-1 were expressed in the adult brain and that their responsiveness to thyroid hormone was retained. These data are the first to identify thyroid hormone-responsive genes in the fetal brain.
Key words: thyroid hormone; neuroendocrine-specific protein; NSP; Oct-1; POU-domain; cerebral cortex; brain development; differential display; congenital hypothyroidism
Copyright © 2000 Society for Neuroscience 0270-6474/00/2062255-11$05.00/0
This article has been cited by other articles:
E. Diamanti-Kandarakis, J.-P. Bourguignon, L. C. Giudice, R. Hauser, G. S. Prins, A. M. Soto, R. T. Zoeller, and A. C. Gore
Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement
Endocr. Rev., June 1, 2009; 30(4): 293 - 342.
[Abstract] [Full Text] [PDF]
L. D. Brewer, A. L. S. Dowling, M. A. Curran-Rauhut, P. W. Landfield, N. M. Porter, and E. M. Blalock
Estradiol Reverses a Calcium-Related Biomarker of Brain Aging in Female Rats
J. Neurosci., May 13, 2009; 29(19): 6058 - 6067.
[Abstract] [Full Text] [PDF]
R. A. Sinha, A. Pathak, V. Mohan, S. Bandyopadhyay, L. Rastogi, and M. M. Godbole
Maternal Thyroid Hormone: A Strong Repressor of Neuronal Nitric Oxide Synthase in Rat Embryonic Neocortex
Endocrinology, September 1, 2008; 149(9): 4396 - 4401.
[Abstract] [Full Text] [PDF]
T. Asua, A. Bilbao, M. A. Gorriti, J. A. Lopez-Moreno, M. del Mar Alvarez, M. Navarro, F. Rodriguez de Fonseca, A. Perez-Castillo, and A. Santos
Implication of the Endocannabinoid System in the Locomotor Hyperactivity Associated with Congenital Hypothyroidism
Endocrinology, May 1, 2008; 149(5): 2657 - 2666.
[Abstract] [Full Text] [PDF]
J. H. Goodman and M. E. Gilbert
Modest Thyroid Hormone Insufficiency during Development Induces a Cellular Malformation in the Corpus Callosum: A Model of Cortical Dysplasia
Endocrinology, June 1, 2007; 148(6): 2593 - 2597.
[Abstract] [Full Text] [PDF]
F. Vermiglio, V. P. Lo Presti, M. Moleti, M. Sidoti, G. Tortorella, G. Scaffidi, M. G. Castagna, F. Mattina, M. A. Violi, A. Crisa, et al.
Attention Deficit and Hyperactivity Disorders in the Offspring of Mothers Exposed to Mild-Moderate Iodine Deficiency: A Possible Novel Iodine Deficiency Disorder in Developed Countries
J. Clin. Endocrinol. Metab., December 1, 2004; 89(12): 6054 - 6060.
[Abstract] [Full Text] [PDF]
D. Forrest
The Developing Brain and Maternal Thyroid Hormone: Finding the Links
Endocrinology, September 1, 2004; 145(9): 4034 - 4036.
[Full Text] [PDF]
E. Auso, R. Lavado-Autric, E. Cuevas, F. E. del Rey, G. Morreale de Escobar, and P. Berbel
A Moderate and Transient Deficiency of Maternal Thyroid Function at the Beginning of Fetal Neocorticogenesis Alters Neuronal Migration
Endocrinology, September 1, 2004; 145(9): 4037 - 4047.
[Abstract] [Full Text] [PDF]
R. M. Calvo, E. Jauniaux, B. Gulbis, M. Asuncion, C. Gervy, B. Contempre, and G. Morreale de Escobar
Fetal Tissues Are Exposed to Biologically Relevant Free Thyroxine Concentrations during Early Phases of Development
J. Clin. Endocrinol. Metab., April 1, 2002; 87(4): 1768 - 1777.
[Abstract] [Full Text] [PDF]
F. R. S. Lima, A. Gervais, C. Colin, M. Izembart, V. M. Neto, and M. Mallat
Regulation of Microglial Development: A Novel Role for Thyroid Hormone
J. Neurosci., March 15, 2001; 21(6): 2028 - 2038.
[Abstract] [Full Text] [PDF]
A. L. S. Dowling, E. A. Iannacone, and R. T. Zoeller
Maternal Hypothyroidism Selectively Affects the Expression of Neuroendocrine-Specific Protein A Messenger Ribonucleic Acid in the Proliferative Zone of the Fetal Rat Brain Cortex
Endocrinology, January 1, 2001; 142(1): 390 - 399.
[Abstract] [Full Text] [PDF]
G. Morreale de Escobar, M. Jesús Obregón, and F. Escobar del Rey
Is Neuropsychological Development Related to Maternal Hypothyroidism or to Maternal Hypothyroxinemia?
J. Clin. Endocrinol. Metab., November 1, 2000; 85(11): 3975 - 3987.
[Abstract] [Full Text]
P. M. G. Pombo, D. Barettino, G. Espliguero, M. Metsis, T. Iglesias, and A. Rodriguez-Pena
Transcriptional Repression of Neurotrophin Receptor trkB by Thyroid Hormone in the Developing Rat Brain
J. Biol. Chem., November 22, 2000; 275(48): 37510 - 37517.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|