 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, April 15, 2000, 20(8):3006-3016
The Control of Rate and Timing of Spikes in the Deep Cerebellar Nuclei by Inhibition
Volker Gauck and Dieter Jaeger Department of Biology, Emory University, Atlanta, Georgia 30322
Cerebellar nucleus neurons were recorded in vitro, and dynamic clamping was used to simulate inhibitory synaptic input from Purkinje cells likely to occur in vivo. Inhibitory input patterns with varying synaptic amplitudes and synchronicity were applied to determine how spike rate and spike timing can be controlled by inhibition. The excitatory input conductance was held constant to isolate the effect of dynamic inhibitory inputs on spiking. We found that the timing of individual spikes was controlled precisely by short decreases in the inhibitory conductance that were the consequence of synchronization between many inputs. The spike rate of nucleus neurons was controlled in a linear way by the rate of inhibitory inputs. The spike rate, however, also depended strongly on the amount of synchronicity present in the inhibitory inputs. An irregular spike train similar to in vivo data resulted from applied synaptic conductances when the conductance was large enough to overcome intrinsic pacemaker currents. In this situation subthreshold fluctuations in membrane potential closely followed the time course of the combined reversal potential of excitation and inhibition. This indicates that the net synaptic driving force for realistic input levels in vivo may be small and that synaptic input may operate primarily by shunting. The accurate temporal control of output spiking by inhibitory input that can be achieved in this way in the deep cerebellar nuclei may be particularly important to allow fine temporal control of movement via inhibitory output from cerebellar cortex.
Key words: cerebellum; Purkinje cell; synaptic; coding; inhibition; dynamic clamp; in vitro; whole cell; synchronization
Copyright © 2000 Society for Neuroscience 0270-6474/00/2083006-11$05.00/0
This article has been cited by other articles:
N. Zheng and I. M. Raman
Ca Currents Activated by Spontaneous Firing and Synaptic Disinhibition in Neurons of the Cerebellar Nuclei
J. Neurosci., August 5, 2009; 29(31): 9826 - 9838.
[Abstract] [Full Text] [PDF]
S. R. Schultz, K. Kitamura, A. Post-Uiterweer, J. Krupic, and M. Hausser
Spatial Pattern Coding of Sensory Information by Climbing Fiber-Evoked Calcium Signals in Networks of Neighboring Cerebellar Purkinje Cells
J. Neurosci., June 24, 2009; 29(25): 8005 - 8015.
[Abstract] [Full Text] [PDF]
F. Saitow, M. Murano, and H. Suzuki
Modulatory Effects of Serotonin on GABAergic Synaptic Transmission and Membrane Properties in the Deep Cerebellar Nuclei
J Neurophysiol, March 1, 2009; 101(3): 1361 - 1374.
[Abstract] [Full Text] [PDF]
F. V. Chirila, K. C. Rowland, J. M. Thompson, and G. A. Spirou
Development of gerbil medial superior olive: integration of temporally delayed excitation and inhibition at physiological temperature
J. Physiol., October 1, 2007; 584(1): 167 - 190.
[Abstract] [Full Text] [PDF]
S. E. Street and P. B. Manis
Action Potential Timing Precision in Dorsal Cochlear Nucleus Pyramidal Cells
J Neurophysiol, June 1, 2007; 97(6): 4162 - 4172.
[Abstract] [Full Text] [PDF]
S.-L. Shin and E. De Schutter
Dynamic Synchronization of Purkinje Cell Simple Spikes
J Neurophysiol, December 1, 2006; 96(6): 3485 - 3491.
[Abstract] [Full Text] [PDF]
R. Dodla, G. Svirskis, and J. Rinzel
Well-Timed, Brief Inhibition Can Promote Spiking: Postinhibitory Facilitation
J Neurophysiol, April 1, 2006; 95(4): 2664 - 2677.
[Abstract] [Full Text] [PDF]
P. O. Kanold and P. B. Manis
Encoding the Timing of Inhibitory Inputs
J Neurophysiol, May 1, 2005; 93(5): 2887 - 2897.
[Abstract] [Full Text] [PDF]
B. E. McKay, M. L. Molineux, W. H. Mehaffey, and R. W. Turner
Kv1 K+ Channels Control Purkinje Cell Output to Facilitate Postsynaptic Rebound Discharge in Deep Cerebellar Neurons
J. Neurosci., February 9, 2005; 25(6): 1481 - 1492.
[Abstract] [Full Text] [PDF]
Z. M. Khaliq and I. M. Raman
Axonal Propagation of Simple and Complex Spikes in Cerebellar Purkinje Neurons
J. Neurosci., January 12, 2005; 25(2): 454 - 463.
[Abstract] [Full Text] [PDF]
D. Wegener, W. A. Freiwald, and A. K. Kreiter
The Influence of Sustained Selective Attention on Stimulus Selectivity in Macaque Visual Area MT
J. Neurosci., July 7, 2004; 24(27): 6106 - 6114.
[Abstract] [Full Text] [PDF]
G. Svirskis, V. Kotak, D. H. Sanes, and J. Rinzel
Sodium Along With Low-Threshold Potassium Currents Enhance Coincidence Detection of Subthreshold Noisy Signals in MSO Neurons
J Neurophysiol, June 1, 2004; 91(6): 2465 - 2473.
[Abstract] [Full Text] [PDF]
L. A. Grande, G. A. Kinney, G. L. Miracle, and W. J. Spain
Dynamic Influences on Coincidence Detection in Neocortical Pyramidal Neurons
J. Neurosci., February 25, 2004; 24(8): 1839 - 1851.
[Abstract] [Full Text] [PDF]
J. E. Hanson, Y. Smith, and D. Jaeger
Sodium Channels and Dendritic Spike Initiation at Excitatory Synapses in Globus Pallidus Neurons
J. Neurosci., January 14, 2004; 24(2): 329 - 340.
[Abstract] [Full Text] [PDF]
V. Gauck and D. Jaeger
The Contribution of NMDA and AMPA Conductances to the Control of Spiking in Neurons of the Deep Cerebellar Nuclei
J. Neurosci., September 3, 2003; 23(22): 8109 - 8118.
[Abstract] [Full Text] [PDF]
C. M. Pedroarena and C. Schwarz
Efficacy and Short-Term Plasticity at GABAergic Synapses Between Purkinje and Cerebellar Nuclei Neurons
J Neurophysiol, February 1, 2003; 89(2): 704 - 715.
[Abstract] [Full Text] [PDF]
G. Svirskis, V. Kotak, D. H. Sanes, and J. Rinzel
Enhancement of Signal-to-Noise Ratio and Phase Locking for Small Inputs by a Low-Threshold Outward Current in Auditory Neurons
J. Neurosci., December 15, 2002; 22(24): 11019 - 11025.
[Abstract] [Full Text] [PDF]
P. Telgkamp and I. M. Raman
Depression of Inhibitory Synaptic Transmission between Purkinje Cells and Neurons of the Cerebellar Nuclei
J. Neurosci., October 1, 2002; 22(19): 8447 - 8457.
[Abstract] [Full Text] [PDF]
J. E. Hanson and D. Jaeger
Short-Term Plasticity Shapes the Response to Simulated Normal and Parkinsonian Input Patterns in the Globus Pallidus
J. Neurosci., June 15, 2002; 22(12): 5164 - 5172.
[Abstract] [Full Text] [PDF]
M. D. Bevan, P. J. Magill, N. E. Hallworth, J. P. Bolam, and C. J. Wilson
Regulation of the Timing and Pattern of Action Potential Generation in Rat Subthalamic Neurons In Vitro by GABA-A IPSPs
J Neurophysiol, March 1, 2002; 87(3): 1348 - 1362.
[Abstract] [Full Text] [PDF]
K. S. Turker and R. K. Powers
Effects of Common Excitatory and Inhibitory Inputs on Motoneuron Synchronization
J Neurophysiol, December 1, 2001; 86(6): 2807 - 2822.
[Abstract] [Full Text] [PDF]
I. M. Raman, A. E. Gustafson, and D. Padgett
Ionic Currents and Spontaneous Firing in Neurons Isolated from the Cerebellar Nuclei
J. Neurosci., December 15, 2000; 20(24): 9004 - 9016.
[Abstract] [Full Text] [PDF]
V. Gauck, M. Thomann, D. Jaeger, and A. Borst
Spatial Distribution of Low- and High-Voltage-Activated Calcium Currents in Neurons of the Deep Cerebellar Nuclei
J. Neurosci., August 1, 2001; 21(15): RC158 - RC158.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|