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Previous Article | Next Article
The Journal of Neuroscience, May 1, 2000, 20(9):3214-3220
Synucleins Are Developmentally Expressed, and
-Synuclein Regulates the Size of the Presynaptic Vesicular Pool in Primary Hippocampal Neurons
Diane D. Murphy, Susan M. Rueter, John Q. Trojanowski, and Virginia M.-Y. Lee Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104
-,
-, and
-Synuclein, a novel family of neuronal proteins, has become the focus of research interest because
Key words: Lewy bodies; Parkinson's disease; primary neurons; synapse; synuclein; vesicle
Copyright © 2000 Society for Neuroscience 0270-6474/00/2093214-07$05.00/0
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Alpha-synuclein degradation by serine protease neurosin: implication for pathogenesis of synucleinopathies
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D. C. Mash, Q. Ouyang, J. Pablo, M. Basile, S. Izenwasser, A. Lieberman, and R. J. Perrin
Cocaine Abusers Have an Overexpression of alpha -Synuclein in Dopamine Neurons
J. Neurosci., April 1, 2003; 23(7): 2564 - 2571.
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W. Dauer, N. Kholodilov, M. Vila, A.-C. Trillat, R. Goodchild, K. E. Larsen, R. Staal, K. Tieu, Y. Schmitz, C. A. Yuan, et al.
From the Cover: Resistance of alpha -synuclein null mice to the parkinsonian neurotoxin MPTP
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D. E. Cabin, K. Shimazu, D. Murphy, N. B. Cole, W. Gottschalk, K. L. McIlwain, B. Orrison, A. Chen, C. E. Ellis, R. Paylor, et al.
Synaptic Vesicle Depletion Correlates with Attenuated Synaptic Responses to Prolonged Repetitive Stimulation in Mice Lacking alpha -Synuclein
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J. Lotharius, S. Barg, P. Wiekop, C. Lundberg, H. K. Raymon, and P. Brundin
Effect of Mutant alpha -Synuclein on Dopamine Homeostasis in a New Human Mesencephalic Cell Line
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J. Lotharius and P. Brundin
Impaired dopamine storage resulting from {alpha}-synuclein mutations may contribute to the pathogenesis of Parkinson's disease
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C. S. Ribeiro, K. Carneiro, C. A. Ross, J. R. L. Menezes, and S. Engelender
Synphilin-1 Is Developmentally Localized to Synaptic Terminals, and Its Association with Synaptic Vesicles Is Modulated by alpha -Synuclein
J. Biol. Chem., June 21, 2002; 277(26): 23927 - 23933.
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R. G. Perez, J. C. Waymire, E. Lin, J. J. Liu, F. Guo, and M. J. Zigmond
A Role for alpha -Synuclein in the Regulation of Dopamine Biosynthesis
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N. B. Cole, D. D. Murphy, T. Grider, S. Rueter, D. Brasaemle, and R. L. Nussbaum
Lipid Droplet Binding and Oligomerization Properties of the Parkinson's Disease Protein alpha -Synuclein
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[Abstract] [Full Text] [PDF]
B. Wolozin and N. Golts
Book Review: Iron and Parkinson's Disease
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[Abstract] [PDF]
R. J. Perrin, W. S. Woods, D. F. Clayton, and J. M. George
Exposure to Long Chain Polyunsaturated Fatty Acids Triggers Rapid Multimerization of Synucleins
J. Biol. Chem., November 2, 2001; 276(45): 41958 - 41962.
[Abstract] [Full Text] [PDF]
R. Sharon, M. S. Goldberg, I. Bar-Josef, R. A. Betensky, J. Shen, and D. J. Selkoe
alpha -Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins
PNAS, July 31, 2001; 98(16): 9110 - 9115.
[Abstract] [Full Text] [PDF]
S. J. Tabrizi, M. Orth, J. M. Wilkinson, J.-W. Taanman, T. T. Warner, J. M. Cooper, and A. H.V. Schapira
Expression of mutant {alpha}-synuclein causes increased susceptibility to dopamine toxicity
Hum. Mol. Genet., November 1, 2000; 9(18): 2683 - 2689.
[Abstract] [Full Text] [PDF]
E. Jo, J. McLaurin, C. M. Yip, P. St. George-Hyslop, and P. E. Fraser
alpha -Synuclein Membrane Interactions and Lipid Specificity
J. Biol. Chem., October 27, 2000; 275(44): 34328 - 34334.
[Abstract] [Full Text] [PDF]
R. J. Perrin, W. S. Woods, D. F. Clayton, and J. M. George
Interaction of Human alpha -Synuclein and Parkinson's Disease Variants with Phospholipids. STRUCTURAL ANALYSIS USING SITE-DIRECTED MUTAGENESIS
J. Biol. Chem., October 27, 2000; 275(44): 34393 - 34398.
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A. L. Biere, S. J. Wood, J. Wypych, S. Steavenson, Y. Jiang, D. Anafi, F. W. Jacobsen, M. A. Jarosinski, G.-M. Wu, J.-C. Louis, et al.
Parkinson's Disease-associated alpha -Synuclein Is More Fibrillogenic than beta - and gamma -Synuclein and Cannot Cross-seed Its Homologs
J. Biol. Chem., October 27, 2000; 275(44): 34574 - 34579.
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C. E. Ellis, P. L. Schwartzberg, T. L. Grider, D. W. Fink, and R. L. Nussbaum
alpha -Synuclein Is Phosphorylated by Members of the Src Family of Protein-tyrosine Kinases
J. Biol. Chem., February 2, 2001; 276(6): 3879 - 3884.
[Abstract] [Full Text] [PDF]
V. N. Uversky, J. Li, and A. L. Fink
Evidence for a Partially Folded Intermediate in alpha -Synuclein Fibril Formation
J. Biol. Chem., March 30, 2001; 276(14): 10737 - 10744.
[Abstract] [Full Text] [PDF]
M. S. Nielsen, H. Vorum, E. Lindersson, and P. H. Jensen
Ca2+ Binding to alpha -Synuclein Regulates Ligand Binding and Oligomerization
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[Abstract] [Full Text] [PDF]
J. Y. Sung, J. Kim, S. R. Paik, J. H. Park, Y. S. Ahn, and K. C. Chung
Induction of Neuronal Cell Death by Rab5A-dependent Endocytosis of alpha -Synuclein
J. Biol. Chem., July 13, 2001; 276(29): 27441 - 27448.
[Abstract] [Full Text] [PDF]
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