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The Journal of Neuroscience, May 1, 2000, 20(9):3369-3376
Classical Conditioning of Feeding in Aplysia: I. Behavioral Analysis
Hilde A. Lechner, Douglas A. Baxter, and John H. Byrne Department of Neurobiology and Anatomy, W. M. Keck Center for the Neurobiology of Learning and Memory, The University of Texas, Houston Medical School, Houston, Texas 77030
A training protocol was developed to classically condition feeding behavior in Aplysia californica using tactile stimulation of the lips as the conditional stimulus (CS) and food as the unconditional stimulus (US). Paired training induced a greater increase in the number of bites to the CS than unpaired training or US-only stimulation. Memory for classical conditioning was retained for at least 24 hr. The organization of the reinforcement pathway that supports classical conditioning was analyzed in additional behavioral experiments. No evidence was found for the contribution to appetitive reinforcement of US-mediating pathways originating in the lips of the animals. Bilateral lesions of the anterior branch of the esophageal nerve, which innervates parts of the foregut, however, were found to attenuate classical conditioning. Thus, it appears likely that reinforcement during appetitive classical conditioning of feeding was mediated by afferent pathways that originate in the foregut. The companion paper (Lechner et al., 2000) describes two neurophysiological correlates of the classical conditioning.
Key words: learning and memory; classical conditioning; feeding behavior; Aplysia; sensory pathway; long-term memory
Copyright © 2000 Society for Neuroscience 0270-6474/00/2093369-08$05.00/0
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