 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, January 1, 2001, 21(1):143-149
Presynaptic Role of cGMP-Dependent Protein Kinase during Long-Lasting Potentiation
Ottavio Arancio1, Irina Antonova1, Stepan Gambaryan2, Suzanne M. Lohmann2, Jason S. Wood3, David S. Lawrence3, and Robert D. Hawkins1, 4 1 Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, 2 Institute of Clinical Biochemistry and Pathobiochemistry, University of Wuerzburg, 97080 Wuerzburg, Germany, 3 Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, and 4 New York State Psychiatric Institute, New York, New York 10032
Previous research has suggested that cGMP-dependent protein kinases (cGKs) may play a role in long-term potentiation in hippocampus, but their site of action has been unknown. We examined this question at synapses between pairs of hippocampal neurons in dissociated cell culture. Injection of a specific peptide inhibitor of cGK into the presynaptic but not the postsynaptic neuron blocked long-lasting potentiation induced by tetanic stimulation of the presynaptic neuron. As controls, injection of a scrambled peptide or a peptide inhibitor of cAMP-dependent protein kinase into either neuron did not block potentiation. Conversely, injection of the
isozyme of cGK type I into the presynaptic but not the postsynaptic neuron produced activity-dependent potentiation that did not require NMDA receptor activation. Evidence from Western blots, reverse transcription-PCR, activity assays, and immunocytochemistry indicates that endogenous cGK type I is present in the neurons, including presynaptic terminals. These results support the idea that cGK plays an important presynaptic role during the induction of long-lasting potentiation in hippocampal neurons.
Key words: presynaptic; cGMP; protein kinase; potentiation; hippocampus; culture
Copyright © 2001 Society for Neuroscience 0270-6474/01/211143-07$05.00/0
This article has been cited by other articles:
J. B. Kelley, M. A. Balda, K. L. Anderson, and Y. Itzhak
Impairments in fear conditioning in mice lacking the nNOS gene
Learn. Mem., May 23, 2009; 16(6): 371 - 378.
[Abstract] [Full Text] [PDF]
C. Paul, F. Schoberl, P. Weinmeister, V. Micale, C. T. Wotjak, F. Hofmann, and T. Kleppisch
Signaling through cGMP-Dependent Protein Kinase I in the Amygdala Is Critical for Auditory-Cued Fear Memory and Long-Term Potentiation
J. Neurosci., December 24, 2008; 28(52): 14202 - 14212.
[Abstract] [Full Text] [PDF]
K. T. Ota, V. J. Pierre, J. E. Ploski, K. Queen, and G. E. Schafe
The NO-cGMP-PKG signaling pathway regulates synaptic plasticity and fear memory consolidation in the lateral amygdala via activation of ERK/MAP kinase
Learn. Mem., October 2, 2008; 15(10): 792 - 805.
[Abstract] [Full Text] [PDF]
G.-D. Chen, M.-L. Peng, P.-Y. Wang, S.-D. Lee, H.-M. Chang, S.-F. Pan, M.-J. Chen, K.-C. Tung, C.-Y. Lai, and T.-B. Lin
Calcium/calmodulin-dependent kinase II mediates NO-elicited PKG activation to participate in spinal reflex potentiation in anesthetized rats
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2008; 294(2): R487 - R493.
[Abstract] [Full Text] [PDF]
E. Szabadits, C. Cserep, A. Ludanyi, I. Katona, J. Gracia-Llanes, T. F. Freund, and G. Nyiri
Hippocampal GABAergic Synapses Possess the Molecular Machinery for Retrograde Nitric Oxide Signaling
J. Neurosci., July 25, 2007; 27(30): 8101 - 8111.
[Abstract] [Full Text] [PDF]
K. R. Kaun, T. Hendel, B. Gerber, and M. B. Sokolowski
Natural variation in Drosophila larval reward learning and memory due to a cGMP-dependent protein kinase
Learn. Mem., May 3, 2007; 14(5): 342 - 349.
[Abstract] [Full Text] [PDF]
V. A. Straub, J. Grant, M. O'Shea, and P. R. Benjamin
Modulation of Serotonergic Neurotransmission by Nitric Oxide
J Neurophysiol, February 1, 2007; 97(2): 1088 - 1099.
[Abstract] [Full Text] [PDF]
A. Haghikia, E. Mergia, A. Friebe, U. T. Eysel, D. Koesling, and T. Mittmann
Long-Term Potentiation in the Visual Cortex Requires Both Nitric Oxide Receptor Guanylyl Cyclases
J. Neurosci., January 24, 2007; 27(4): 818 - 823.
[Abstract] [Full Text] [PDF]
R. D. Hawkins, E. R. Kandel, and C. H. Bailey
Molecular Mechanisms of Memory Storage in Aplysia
Biol. Bull., June 1, 2006; 210(3): 174 - 191.
[Abstract] [Full Text] [PDF]
F.-M. Lu and R. D. Hawkins
Presynaptic and postsynaptic Ca2+ and CamKII contribute to long-term potentiation at synapses between individual CA3 neurons.
PNAS, March 14, 2006; 103(11): 4264 - 4269.
[Abstract] [Full Text] [PDF]
F. Hofmann, R. Feil, T. Kleppisch, and J. Schlossmann
Function of cGMP-Dependent Protein Kinases as Revealed by Gene Deletion
Physiol Rev, January 1, 2006; 86(1): 1 - 23.
[Abstract] [Full Text] [PDF]
A. Ledo, R. M. Barbosa, G. A. Gerhardt, E. Cadenas, and J. Laranjinha
Concentration dynamics of nitric oxide in rat hippocampal subregions evoked by stimulation of the NMDA glutamate receptor
PNAS, November 29, 2005; 102(48): 17483 - 17488.
[Abstract] [Full Text] [PDF]
D. Puzzo, O. Vitolo, F. Trinchese, J. P. Jacob, A. Palmeri, and O. Arancio
Amyloid-{beta} Peptide Inhibits Activation of the Nitric Oxide/cGMP/cAMP-Responsive Element-Binding Protein Pathway during Hippocampal Synaptic Plasticity
J. Neurosci., July 20, 2005; 25(29): 6887 - 6897.
[Abstract] [Full Text] [PDF]
F. Hofmann
The Biology of Cyclic GMP-dependent Protein Kinases
J. Biol. Chem., January 7, 2005; 280(1): 1 - 4.
[Full Text] [PDF]
V. O'Connor, A. Genin, S. Davis, K. K. Karishma, V. Doyere, C. I. De Zeeuw, G. Sanger, S. P. Hunt, G. Richter-Levin, J. Mallet, et al.
Differential Amplification of Intron-containing Transcripts Reveals Long Term Potentiation-associated Up-regulation of Specific Pde10A Phosphodiesterase Splice Variants
J. Biol. Chem., April 16, 2004; 279(16): 15841 - 15849.
[Abstract] [Full Text] [PDF]
A. J. Susswein, A. Katzoff, N. Miller, and I. Hurwitz
Nitric Oxide and Memory
Neuroscientist, April 1, 2004; 10(2): 153 - 162.
[Abstract] [PDF]
A. Maffei, F. Prestori, K. Shibuki, P. Rossi, V. Taglietti, and E. D'Angelo
NO Enhances Presynaptic Currents During Cerebellar Mossy Fiber--Granule Cell LTP
J Neurophysiol, October 1, 2003; 90(4): 2478 - 2483.
[Abstract] [Full Text] [PDF]
S. Liu, Y. Rao, and N. Daw
Roles of Protein Kinase A and Protein Kinase G in Synaptic Plasticity in the Visual Cortex
Cereb Cortex, August 1, 2003; 13(8): 864 - 869.
[Abstract] [Full Text] [PDF]
T. Kleppisch, W. Wolfsgruber, S. Feil, R. Allmann, C. T. Wotjak, S. Goebbels, K.-A. Nave, F. Hofmann, and R. Feil
Hippocampal cGMP-Dependent Protein Kinase I Supports an Age- and Protein Synthesis-Dependent Component of Long-Term Potentiation But Is Not Essential for Spatial Reference and Contextual Memory
J. Neurosci., July 9, 2003; 23(14): 6005 - 6012.
[Abstract] [Full Text] [PDF]
P. K. Stanton, J. Winterer, C. P. Bailey, A. Kyrozis, I. Raginov, G. Laube, R. W. Veh, C. Q. Nguyen, and W. Muller
Long-Term Depression of Presynaptic Release from the Readily Releasable Vesicle Pool Induced by NMDA Receptor-Dependent Retrograde Nitric Oxide
J. Neurosci., July 2, 2003; 23(13): 5936 - 5944.
[Abstract] [Full Text] [PDF]
Y. Chen, S. Zhuang, S. Cassenaer, D. E. Casteel, T. Gudi, G. R. Boss, and R. B. Pilz
Synergism between Calcium and Cyclic GMP in Cyclic AMP Response Element-Dependent Transcriptional Regulation Requires Cooperation between CREB and C/EBP-{beta}
Mol. Cell. Biol., June 15, 2003; 23(12): 4066 - 4082.
[Abstract] [Full Text] [PDF]
W.-L. Chien, K.-C. Liang, C.-M. Teng, S.-C. Kuo, F.-Y. Lee, and W.-M. Fu
Enhancement of Long-Term Potentiation by a Potent Nitric Oxide-Guanylyl Cyclase Activator, 3-(5-Hydroxymethyl-2-furyl)-1-benzyl-indazole
Mol. Pharmacol., June 1, 2003; 63(6): 1322 - 1328.
[Abstract] [Full Text] [PDF]
C. L. M. Bon and J. Garthwaite
On the Role of Nitric Oxide in Hippocampal Long-Term Potentiation
J. Neurosci., March 1, 2003; 23(5): 1941 - 1948.
[Abstract] [Full Text] [PDF]
P. Monfort, M.-D. Munoz, E. Kosenko, and V. Felipo
Long-Term Potentiation in Hippocampus Involves Sequential Activation of Soluble Guanylate Cyclase, cGMP-Dependent Protein Kinase, and cGMP-Degrading Phosphodiesterase
J. Neurosci., December 1, 2002; 22(23): 10116 - 10122.
[Abstract] [Full Text] [PDF]
A. Burette, U. Zabel, R. J. Weinberg, H. H. H. W. Schmidt, and J. G. Valtschanoff
Synaptic Localization of Nitric Oxide Synthase and Soluble Guanylyl Cyclase in the Hippocampus
J. Neurosci., October 15, 2002; 22(20): 8961 - 8970.
[Abstract] [Full Text] [PDF]
M. K. Taylor, R. Ahmed, M. Begley, and M. D. Uhler
Autoinhibition and Isoform-specific Dominant Negative Inhibition of the Type II cGMP-dependent Protein Kinase
J. Biol. Chem., September 27, 2002; 277(40): 37242 - 37253.
[Abstract] [Full Text] [PDF]
Y.-F. Lu and R. D. Hawkins
Ryanodine Receptors Contribute to cGMP-Induced Late-Phase LTP and CREB Phosphorylation in the Hippocampus
J Neurophysiol, September 1, 2002; 88(3): 1270 - 1278.
[Abstract] [Full Text] [PDF]
H. Checkoway, K. Powers, T. Smith-Weller, G. M. Franklin, W. T. Longstreth Jr., and P. D. Swanson
Parkinson's Disease Risks Associated with Cigarette Smoking, Alcohol Consumption, and Caffeine Intake
Am. J. Epidemiol., April 15, 2002; 155(8): 732 - 738.
[Abstract] [Full Text] [PDF]
C. A. Leamey, C. L. Ho-Pao, and M. Sur
Disruption of Retinogeniculate Pattern Formation by Inhibition of Soluble Guanylyl Cyclase
J. Neurosci., June 1, 2001; 21(11): 3871 - 3880.
[Abstract] [Full Text] [PDF]
P. K. Stanton, U. Heinemann, and W. Muller
FM1-43 Imaging Reveals cGMP-Dependent Long-Term Depression of Presynaptic Transmitter Release
J. Neurosci., October 1, 2001; 21(19): RC167 - RC167.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|