QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (34) Citing Articles via Google Scholar Google Scholar Articles by Quirk, M. C. Articles by Wilson, M. A. Search for Related Content PubMed PubMed Citation Articles by Quirk, M. C. Articles by Wilson, M. A.

 Previous Article  |  Next Article 

The Journal of Neuroscience, January 1, 2001, 21(1):240-248

Experience-Dependent Changes in Extracellular Spike Amplitude May Reflect Regulation of Dendritic Action Potential Back-Propagation in Rat Hippocampal Pyramidal Cells

Michael C. Quirk, Kenneth I. Blum, and Matthew A. Wilson

The Department of Brain and Cognitive Sciences, Center for Learning and Memory, and the RIKEN-Massachusetts Institute of Technology Neuroscience Research Center, The Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

Activity-dependent attenuations in extracellular spike amplitude have been shown to correlate with a decrease in the effectiveness with which somatic action potentials back-propagate into the dendritic arbor of hippocampal pyramidal cells. In this paper we demonstrate that activity-dependent attenuations in amplitude occur during behavior and that the amount of attenuation is reduced with an animal's experience in an environment. The observed reductions are caused by an animal's experience within a specific environmental context, are dependent on functional NMDA receptors, and are accompanied by an increase in the effective coupling of pyramidal cells and interneurons. These results provide an important step in linking together in vivo studies with in vitro data and suggest that mechanisms of plasticity engaged during behavior may be sufficient to alter the biophysical and integrative properties of hippocampal pyramidal cells.

Key words: back-propagation; plasticity; hippocampus; freely behaving rat; NMDA; extracellular spike amplitude

---

Copyright © 2001 Society for Neuroscience  0270-6474/01/211240-09$05.00/0

This article has been cited by other articles:

				J. Waters and F. Helmchen Background synaptic activity is sparse in neocortex. J. Neurosci., August 9, 2006; 26(32): 8267 - 8277. [Abstract] [Full Text] [PDF]

				C. Gold, D. A. Henze, C. Koch, and G. Buzsaki On the Origin of the Extracellular Action Potential Waveform: A Modeling Study J Neurophysiol, May 1, 2006; 95(5): 3113 - 3128. [Abstract] [Full Text] [PDF]

				R. J. Kyd and D. K. Bilkey Hippocampal Place Cells Show Increased Sensitivity to Changes in the Local Environment Following Prefrontal Cortex Lesions Cereb Cortex, June 1, 2005; 15(6): 720 - 731. [Abstract] [Full Text] [PDF]

				G. Daoudal and D. Debanne Long-Term Plasticity of Intrinsic Excitability: Learning Rules and Mechanisms Learn. Mem., November 1, 2003; 10(6): 456 - 465. [Abstract] [Full Text] [PDF]

				J. Waters, M. Larkum, B. Sakmann, and F. Helmchen Supralinear Ca2+ Influx into Dendritic Tufts of Layer 2/3 Neocortical Pyramidal Neurons In Vitro and In Vivo J. Neurosci., September 17, 2003; 23(24): 8558 - 8567. [Abstract] [Full Text] [PDF]

				C. Bernard and D. Johnston Distance-Dependent Modifiable Threshold for Action Potential Back-Propagation in Hippocampal Dendrites J Neurophysiol, September 1, 2003; 90(3): 1807 - 1816. [Abstract] [Full Text] [PDF]

				J. Csicsvari, D. A. Henze, B. Jamieson, K. D. Harris, A. Sirota, P. Bartho, K. D. Wise, and G. Buzsaki Massively Parallel Recording of Unit and Local Field Potentials With Silicon-Based Electrodes J Neurophysiol, August 1, 2003; 90(2): 1314 - 1323. [Abstract] [Full Text] [PDF]

				L. A. Schrader, A. E. Anderson, A. Mayne, P. J. Pfaffinger, and J. D. Sweatt PKA Modulation of Kv4.2-Encoded A-Type Potassium Channels Requires Formation of a Supramolecular Complex J. Neurosci., December 1, 2002; 22(23): 10123 - 10133. [Abstract] [Full Text] [PDF]

				M. C. Tresch and O. Kiehn Synchronization of Motor Neurons during Locomotion in the Neonatal Rat: Predictors and Mechanisms J. Neurosci., November 15, 2002; 22(22): 9997 - 10008. [Abstract] [Full Text] [PDF]

				K. Nakazawa, M. C. Quirk, R. A. Chitwood, M. Watanabe, M. F. Yeckel, L. D. Sun, A. Kato, C. A. Carr, D. Johnston, M. A. Wilson, et al. Requirement for Hippocampal CA3 NMDA Receptors in Associative Memory Recall Science, July 12, 2002; 297(5579): 211 - 218. [Abstract] [Full Text] [PDF]

				L.-L. Yuan, J. P. Adams, M. Swank, J. D. Sweatt, and D. Johnston Protein Kinase Modulation of Dendritic K+ Channels in Hippocampus Involves a Mitogen-Activated Protein Kinase Pathway J. Neurosci., June 15, 2002; 22(12): 4860 - 4868. [Abstract] [Full Text] [PDF]

				S. Watanabe, D. A. Hoffman, M. Migliore, and D. Johnston Dendritic K+ channels contribute to spike-timing dependent long-term potentiation in hippocampal pyramidal neurons PNAS, June 11, 2002; 99(12): 8366 - 8371. [Abstract] [Full Text] [PDF]

				Y.-N. Jan and L. Y. Jan Dendrites Genes & Dev., October 15, 2001; 15(20): 2627 - 2641. [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help