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Previous Article | Next Article
The Journal of Neuroscience, May 15, 2001, 21(10):3312-3321
Action Potential Bursting in Subicular Pyramidal Neurons Is Driven by a Calcium Tail Current
Hae-yoon Jung, Nathan P. Staff, and Nelson Spruston Department of Neurobiology and Physiology, Institute for Neuroscience, Northwestern University, Evanston, Illinois 60208
Subiculum is the primary output area of the hippocampus and serves as a key relay center in the process of memory formation and retrieval. A majority of subicular pyramidal neurons communicate via bursts of action potentials, a mode of signaling that may enhance the fidelity of information transfer and synaptic plasticity or contribute to epilepsy when unchecked. In the present study, we show that a Ca2+ tail current drives bursting in subicular pyramidal neurons. An action potential activates voltage-activated Ca2+ channels, which deactivate slowly enough during action potential repolarization to produce an afterdepolarization that triggers subsequent action potentials in the burst. The Ca2+ channels underlying bursting are located primarily near the soma, and the amplitude of Ca2+ tail currents correlates with the strength of bursting across cells. Multiple channel subtypes contribute to Ca2+ tail current, but the need for an action potential to produce the slow depolarization suggests a central role for high-voltage-activated Ca2+ channels in subicular neuron bursting.
Key words: Ca2+ currents; HVA channels; bursting mechanism; subiculum; hippocampus; patch clamp
Copyright © 2001 Society for Neuroscience 0270-6474/01/21103312-10$05.00/0
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