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Previous Article | Next Article
The Journal of Neuroscience, May 15, 2001, 21(10):3369-3374
Neuron-Specific Expression of Mutant Superoxide Dismutase 1 in Transgenic Mice Does Not Lead to Motor Impairment
Albéna Pramatarova, Janet Laganière, Julie Roussel, Katéri Brisebois, and Guy A. Rouleau Centre for Research in Neuroscience, McGill University, and the Montreal General Hospital Research Institute, Montreal, Quebec, H3G 1A4, Canada
Mutations were identified in the Cu/Zn superoxide dismutase gene (SOD1) in ~15% of patients with familial amyotrophic lateral sclerosis. Transgenic animals expressing mutant SOD1 in all tissues develop an ALS-like phenotype. To determine whether neuron-specific expression of mutant SOD1 is sufficient to produce such a phenotype, we generated transgenic animals carrying the G37R mutation that is associated with the familial form of ALS (FALS), which is driven by the neurofilament light chain promoter. The transgenic animals express high levels of the human SOD1 protein in neuronal tissues, especially in the large motor neurons of the spinal cord, but they show no apparent motor deficit at up to 1.5 years of age. Our animal model suggests that neuron-specific expression of ALS-associated mutant human SOD1 may not be sufficient for the development of the disease in mice.
Key words: amyotrophic lateral sclerosis; superoxide dismutase; mutant SOD1; transgenic mice; neuronal expression; cell death; neurofilament promoter
Copyright © 2001 Society for Neuroscience 0270-6474/01/21103369-06$05.00/0
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