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The Journal of Neuroscience, May 15, 2001, 21(10):3600-3608

Layer-Specific Input to Distinct Cell Types in Layer 6 of Monkey Primary Visual Cortex

Farran Briggs and Edward M. Callaway

Systems Neurobiology Laboratories, Salk Institute for Biological Sciences and Department of Biology, University of California, San Diego, La Jolla, California 92037

Layer 6 of monkey V1 contains a physiologically and anatomically diverse population of excitatory pyramidal neurons. Distinctive arborization patterns of axons and dendrites within the functionally specialized cortical layers define eight types of layer 6 pyramidal neurons and suggest unique information processing roles for each cell type. To address how input sources contribute to cellular function, we examined the laminar sources of functional excitatory input onto individual layer 6 pyramidal neurons using scanning laser photostimulation. We find that excitatory input sources correlate with cell type. Class I neurons with axonal arbors selectively targeting magnocellular (M) recipient layer 4C receive input from M-dominated layer 4B, whereas class I neurons whose axonal arbors target parvocellular (P) recipient layer 4C receive input from P-dominated layer 2/3. Surprisingly, these neuronal types do not differ significantly in the inputs they receive directly from layers 4C or 4C. Class II cells, which lack dense axonal arbors within layer 4C, receive excitatory input from layers targeted by their local axons. Specifically, type IIA cells project axons to and receive input from the deep but not superficial layers. Type IIB neurons project to and receive input from the deepest and most superficial, but not middle layers. Type IIC neurons arborize throughout the cortical layers and tend to receive inputs from all cortical layers. These observations have implications for the functional roles of different layer 6 cell types in visual information processing.

Key words: macaque; visual cortex; V1; layer 6; photostimulation; excitatory input; local circuits; caged glutamate

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Copyright © 2001 Society for Neuroscience  0270-6474/01/21103600-09$05.00/0

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