 |
||||
|
||||
|
||||
|
||||
Previous Article | Next Article
The Journal of Neuroscience, June 15, 2001, 21(12):4299-4309
Suppression of Cortical NMDA Receptor Function Prevents Development of Orientation Selectivity in the Primary Visual Cortex
Ary S. Ramoa, Amanda F. Mower, David Liao, and Syed I. A. Jafri Department of Anatomy, Visual/Motor Neuroscience Division, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298-0709
Selectivity to visual stimulus orientation is a basic cortical functional property believed to be crucial for normal vision. Maturation of this neuronal property requires neural activity. Still, it is unclear what might be the molecular basis for such activity-dependent processes and whether activity has an instructive or permissive role in development of orientation selectivity. There is strong evidence that the NMDA subtype of the glutamate receptor regulates activity-dependent mechanisms of ocular dominance plasticity during cortical development. For this reason, we have hypothesized that the NMDA receptor participates in activity-dependent mechanisms that sculpt orientation selectivity of cortical neurons. We used chronic in vivo infusion of antisense oligodeoxynucleotides (ODNs) to suppress NMDA receptor function in primary visual cortex during the period when orientation selectivity develops in ferrets. Chronic suppression of NMDA receptor function prevented the development of orientation and stimulus size selectivity in most cortical cells tested. In contrast, treatment with control sense or missense ODNs did not affect development of orientation selectivity, indicating specificity of effects. Importantly, antisense ODN treatment did not impair visually driven activity, which is required for development to occur. Moreover, orientation selectivity of cortical cells was not disrupted by antisense ODN treatment in mature animals, indicating developmental relevance of the effects. In conclusion, our findings document for the first time that cortical NMDA receptors are essential for the maturation of orientation selectivity. This result supports the notion that activity has an instructive role in sculpting the connections that underlie orientation selectivity in visual cortex.
Key words: NMDA receptor; orientation selectivity; visual cortex; ferret; development; receptive field properties; antisense oligodeoxynucleotide
Copyright © 2001 Society for Neuroscience 0270-6474/01/21124299-11$05.00/0
This article has been cited by other articles:
J. de Marchena, A. C. Roberts, P. G. Middlebrooks, V. Valakh, K. Yashiro, L. R. Wilfley, and B. D. Philpot
NMDA Receptor Antagonists Reveal Age-Dependent Differences in the Properties of Visual Cortical Plasticity
J Neurophysiol, October 1, 2008; 100(4): 1936 - 1948.
[Abstract] [Full Text] [PDF]
M. Constantine-Paton
Pioneers of cortical plasticity: six classic papers by Wiesel and Hubel
J Neurophysiol, June 1, 2008; 99(6): 2741 - 2744.
[Abstract] [Full Text] [PDF]
S. Gais, B. Rasch, U. Wagner, and J. Born
Visual-Procedural Memory Consolidation during Sleep Blocked by Glutamatergic Receptor Antagonists
J. Neurosci., May 21, 2008; 28(21): 5513 - 5518.
[Abstract] [Full Text] [PDF]
R. J. Clarke and J. W. Johnson
NMDA Receptor NR2 Subunit Dependence of the Slow Component of Magnesium Unblock
J. Neurosci., May 24, 2006; 26(21): 5825 - 5834.
[Abstract] [Full Text] [PDF]
A. E. Medina, T. E. Krahe, and A. S. Ramoa
Early Alcohol Exposure Induces Persistent Alteration of Cortical Columnar Organization and Reduced Orientation Selectivity in the Visual Cortex
J Neurophysiol, March 1, 2005; 93(3): 1317 - 1325.
[Abstract] [Full Text] [PDF]
A. Qian, A. L. Buller, and J. W. Johnson
NR2 subunit-dependence of NMDA receptor channel block by external Mg2+
J. Physiol., January 15, 2005; 562(2): 319 - 331.
[Abstract] [Full Text] [PDF]
N. Uesaka, S. Hirai, T. Maruyama, E. S. Ruthazer, and N. Yamamoto
Activity Dependence of Cortical Axon Branch Formation: A Morphological and Electrophysiological Study Using Organotypic Slice Cultures
J. Neurosci., January 5, 2005; 25(1): 1 - 9.
[Abstract] [Full Text] [PDF]
V. M. Andre, J. Flores-Hernandez, C. Cepeda, A. J. Starling, S. Nguyen, M. K. Lobo, H. V. Vinters, M. S. Levine, and G. W. Mathern
NMDA Receptor Alterations in Neurons from Pediatric Cortical Dysplasia Tissue
Cereb Cortex, June 1, 2004; 14(6): 634 - 646.
[Abstract] [Full Text] [PDF]
L. Cancedda, E. Putignano, A. Sale, A. Viegi, N. Berardi, and L. Maffei
Acceleration of Visual System Development by Environmental Enrichment
J. Neurosci., May 19, 2004; 24(20): 4840 - 4848.
[Abstract] [Full Text] [PDF]
A. E. Medina, T. E. Krahe, D. M. Coppola, and A. S. Ramoa
Neonatal Alcohol Exposure Induces Long-Lasting Impairment of Visual Cortical Plasticity in Ferrets
J. Neurosci., November 5, 2003; 23(31): 10002 - 10012.
[Abstract] [Full Text] [PDF]
M. Fagiolini, H. Katagiri, H. Miyamoto, H. Mori, S. G. N. Grant, M. Mishina, and T. K. Hensch
Separable features of visual cortical plasticity revealed by N-methyl-D-aspartate receptor 2A signaling
PNAS, March 4, 2003; 100(5): 2854 - 2859.
[Abstract] [Full Text] [PDF]
C. J. Beaver, Q. S. Fischer, Q. Ji, and N. W. Daw
Orientation Selectivity Is Reduced by Monocular Deprivation in Combination With PKA Inhibitors
J Neurophysiol, October 1, 2002; 88(4): 1933 - 1940.
[Abstract] [Full Text] [PDF]
A. F. Mower, D. S. Liao, E. J. Nestler, R. L. Neve, and A. S. Ramoa
cAMP/Ca2+ Response Element-Binding Protein Function Is Essential for Ocular Dominance Plasticity
J. Neurosci., March 15, 2002; 22(6): 2237 - 2245.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|