 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, July 1, 2001, 21(13):4864-4874
Contrasting Effects of Ibotenate Lesions of the Paraventricular Nucleus and Subparaventricular Zone on Sleep-Wake Cycle and Temperature Regulation
J. Lu1, Y.-H. Zhang1, T. C. Chou1, S. E. Gaus1, J. K. Elmquist1, P. Shiromani2, and C. B. Saper1 1 Department of Neurology and Program in Neuroscience, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, and 2 Department of Psychiatry, Brockton Veterans Administration Hospital, Harvard Medical School, Boston, Massachusetts 02115
The suprachiasmatic nucleus (SCN), the circadian pacemaker for the brain, provides a massive projection to the subparaventricular zone (SPZ), but the role of the SPZ in circadian processes has received little attention. We examined the effects on circadian rhythms of sleep, body temperature, and activity in rats of restricted ibotenic acid lesions of the ventral or dorsal SPZ that spared the immediately adjacent paraventricular hypothalamic nucleus (PVH) and the SCN. Ventral SPZ lesions caused profound reduction of measures of circadian index of sleep (by 90%) and locomotor activity (75% reduction) but had less effect on body temperature (50% reduction); dorsal SPZ lesions caused greater reduction of circadian index of body temperature (by 70%) but had less effect on circadian index of locomotor activity (45% reduction) or sleep (<5% reduction). The loss of circadian regulation of body temperature or sleep was replaced by a strong ultradian rhythm (period ~3 hr). Lesions of the PVH, immediately dorsal to the SPZ, had no significant effect on any circadian rhythms that we measured, nor did the lesions affect the baseline body temperature. However, the fever response after intravenous injection of lipopolysaccharide (5 µg/kg) was markedly decreased in the rats with PVH lesions (66.6%) but not dorsal SPZ lesions. These results indicate that circadian rhythms of sleep and body temperatures are regulated by separate neuronal populations in the SPZ, and different aspects of thermoregulation (circadian rhythm and fever response) are controlled by distinct anatomical substrates.
Key words: circadian rhythm; ultradian rhythm; ibotenic acid; suprachiasmatic nucleus; c-Fos; fever
Copyright © 2001 Society for Neuroscience 0270-6474/01/21134864-11$05.00/0
This article has been cited by other articles:
M.L.H.J. Hermes, M. Kolaj, P. Doroshenko, E. Coderre, and L. P. Renaud
Effects of VPAC2 Receptor Activation on Membrane Excitability and GABAergic Transmission in Subparaventricular Zone Neurons Targeted by Suprachiasmatic Nucleus
J Neurophysiol, September 1, 2009; 102(3): 1834 - 1842.
[Abstract] [Full Text] [PDF]
A. A. Romanovsky, M. C. Almeida, A. Garami, A. A. Steiner, M. H. Norman, S. F. Morrison, K. Nakamura, J. J. Burmeister, and T. B. Nucci
The Transient Receptor Potential Vanilloid-1 Channel in Thermoregulation: A Thermosensor It Is Not
Pharmacol. Rev., September 1, 2009; 61(3): 228 - 261.
[Abstract] [Full Text] [PDF]
Z. Peterfi, G. B. Makara, F. Obal Jr., and J. M. Krueger
The anterolateral projections of the medial basal hypothalamus affect sleep
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2009; 296(4): R1228 - R1238.
[Abstract] [Full Text] [PDF]
E. L. Bittman
Vasopressin: more than just an output of the circadian pacemaker? Focus on "Vasopressin receptor V1a regulates circadian rhythms of locomotor activity and expression of clock-controlled genes in the suprachiasmatic nuclei"
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2009; 296(3): R821 - R823.
[Full Text] [PDF]
C. J. Madden and S. F. Morrison
Neurons in the paraventricular nucleus of the hypothalamus inhibit sympathetic outflow to brown adipose tissue
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2009; 296(3): R831 - R843.
[Abstract] [Full Text] [PDF]
J. A. Rathner, C. J. Madden, and S. F. Morrison
Central pathway for spontaneous and prostaglandin E2-evoked cutaneous vasoconstriction
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2008; 295(1): R343 - R354.
[Abstract] [Full Text] [PDF]
A. C. Ribeiro, E. Sawa, I. Carren-LeSauter, J. LeSauter, R. Silver, and D. W. Pfaff
Two forces for arousal: Pitting hunger versus circadian influences and identifying neurons responsible for changes in behavioral arousal
PNAS, December 11, 2007; 104(50): 20078 - 20083.
[Abstract] [Full Text] [PDF]
S. Huitron-Resendiz, M. C. G. Marcondes, C. T. Flynn, C. M. S. Lanigan, and H. S. Fox
Effects of simian immunodeficiency virus on the circadian rhythms of body temperature and gross locomotor activity
PNAS, September 18, 2007; 104(38): 15138 - 15143.
[Abstract] [Full Text] [PDF]
A. A. Romanovsky
Thermoregulation: some concepts have changed. Functional architecture of the thermoregulatory system
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R37 - R46.
[Abstract] [Full Text] [PDF]
P. M. Fuller, J. J. Gooley, and C. B. Saper
Neurobiology of the Sleep-Wake Cycle: Sleep Architecture, Circadian Regulation, and Regulatory Feedback
J Biol Rhythms, December 1, 2006; 21(6): 482 - 493.
[Abstract] [PDF]
M. D. Schwartz and L. Smale
Individual Differences in Rhythms of Behavioral Sleep and Its Neural Substrates in Nile Grass Rats
J Biol Rhythms, December 1, 2005; 20(6): 526 - 537.
[Abstract] [PDF]
F. C. Baker, C. Angara, R. Szymusiak, and D. McGinty
Persistence of sleep-temperature coupling after suprachiasmatic nuclei lesions in rats
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2005; 289(3): R827 - R838.
[Abstract] [Full Text] [PDF]
G. B. Lundkvist, K. Kristensson, and M. Bentivoglio
Why Trypanosomes Cause Sleeping Sickness
Physiology, August 1, 2004; 19(4): 198 - 206.
[Abstract] [Full Text] [PDF]
T. Mochizuki, A. Crocker, S. McCormack, M. Yanagisawa, T. Sakurai, and T. E. Scammell
Behavioral State Instability in Orexin Knock-Out Mice
J. Neurosci., July 14, 2004; 24(28): 6291 - 6300.
[Abstract] [Full Text] [PDF]
T. C. Chou, T. E. Scammell, J. J. Gooley, S. E. Gaus, C. B. Saper, and J. Lu
Critical Role of Dorsomedial Hypothalamic Nucleus in a Wide Range of Behavioral Circadian Rhythms
J. Neurosci., November 19, 2003; 23(33): 10691 - 10702.
[Abstract] [Full Text] [PDF]
L. Smale, T. Lee, and A. A. Nunez
Mammalian Diurnality: Some Facts and Gaps
J Biol Rhythms, October 1, 2003; 18(5): 356 - 366.
[Abstract] [PDF]
T. Oka, K. Oka, T. Kobayashi, Y. Sugimoto, A. Ichikawa, F. Ushikubi, S. Narumiya, and C. B Saper
Characteristics of thermoregulatory and febrile responses in mice deficient in prostaglandin EP1 and EP3 receptors
J. Physiol., September 15, 2003; 551(3): 945 - 954.
[Abstract] [Full Text] [PDF]
J. J. Gooley, J. Lu, D. Fischer, and C. B. Saper
A Broad Role for Melanopsin in Nonvisual Photoreception
J. Neurosci., August 6, 2003; 23(18): 7093 - 7106.
[Abstract] [Full Text] [PDF]
D. Aeschbach, L. Sher, T. T. Postolache, J. R. Matthews, M. A. Jackson, and T. A. Wehr
A Longer Biological Night in Long Sleepers Than in Short Sleepers
J. Clin. Endocrinol. Metab., January 1, 2003; 88(1): 26 - 30.
[Abstract] [Full Text] [PDF]
J. E. Larkin, P. Franken, and H. C. Heller
Loss of circadian organization of sleep and wakefulness during hibernation
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2002; 282(4): R1086 - R1095.
[Abstract] [Full Text] [PDF]
D.-J. Dijk and S. W. Lockley
Functional Genomics of Sleep and Circadian Rhythm: Invited Review: Integration of human sleep-wake regulation and circadian rhythmicity
J Appl Physiol, February 1, 2002; 92(2): 852 - 862.
[Abstract] [Full Text] [PDF]
A. Kramer, F.-C. Yang, P. Snodgrass, X. Li, T. E. Scammell, F. C. Davis, and C. J. Weitz
Regulation of Daily Locomotor Activity and Sleep by Hypothalamic EGF Receptor Signaling
Science, December 21, 2001; 294(5551): 2511 - 2515.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|