 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, August 1, 2001, 21(15):5546-5558
Dopamine D1 Receptor-Dependent Trafficking of Striatal NMDA Glutamate Receptors to the Postsynaptic Membrane
Anthone W. Dunah and David G. Standaert Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114
Recent work has shown substantial alterations in NMDA receptor subunit expression, assembly, and phosphorylation in the dopamine-depleted striatum of a rodent 6-hydroxydopamine model of Parkinson's disease. These modifications are hypothesized to result from the trafficking of NMDA receptors between subcellular compartments. Here we show that in rat striatal tissues the NR2A and NR2B subunits in the synaptosomal membrane, and not those in the light membrane and synaptic vesicle-enriched compartments, are tyrosine phosphorylated. The dopamine D1 receptor agonist SKF-82958 produces (1) an increase in NR1, NR2A, and NR2B proteins in the synaptosomal membrane fraction; (2) a decrease in NR1, NR2A, and NR2B proteins in the light membrane and synaptic vesicle-enriched fractions; and (3) an increase in the tyrosine phosphorylation of NR2A and NR2B in the synaptosomal membrane compartment. The protein phosphatase inhibitor pervanadate reproduces the alterations in subcellular distribution and phosphorylation, whereas the effects of the dopamine D1 receptor agonist are blocked by genistein, a protein tyrosine kinase inhibitor. Dopamine D1 receptor agonist treatment does not change the subcellular distribution of the AMPA receptor subunits GluR1 or GluR2/3 in the striatum and has no effect on cortical or cerebellar NMDA receptor subunits. These data reveal a rapid dopamine D1 receptor- and tyrosine kinase-dependent trafficking of striatal NMDA receptors between intracellular and postsynaptic sites. The subcellular trafficking of striatal NMDA receptors may play a significant role both in the pathogenesis of Parkinson's disease and in the development of adverse effects of chronic dopaminergic therapy in parkinsonian patients.
Key words: glutamate receptor; NMDA receptor; dopamine receptor; subcellular compartment; receptor trafficking; tyrosine phosphorylation
Copyright © 2001 Society for Neuroscience 0270-6474/01/21155546-13$05.00/0
This article has been cited by other articles:
T.-X. Xu, T. D. Sotnikova, C. Liang, J. Zhang, J. U. Jung, R. D. Spealman, R. R. Gainetdinov, and W.-D. Yao
Hyperdopaminergic Tone Erodes Prefrontal Long-Term Potential via a D2 Receptor-Operated Protein Phosphatase Gate
J. Neurosci., November 11, 2009; 29(45): 14086 - 14099.
[Abstract] [Full Text] [PDF]
C. D. Paspalas, C. C. Perley, D. V. Venkitaramani, S. M. Goebel-Goody, Y. Zhang, P. Kurup, J. H. Mattis, and P. J. Lombroso
Major Vault Protein is Expressed along the Nucleus-Neurite Axis and Associates with mRNAs in Cortical Neurons
Cereb Cortex, July 1, 2009; 19(7): 1666 - 1677.
[Abstract] [Full Text] [PDF]
A. LacKamp, G.-C. Zhang, L.-M. Mao, E. E. Fibuch, and J. Q. Wang
Loss of surface N-methyl-D-aspartate receptor proteins in mouse cortical neurones during anaesthesia induced by chloral hydrate in vivo
Br. J. Anaesth., April 1, 2009; 102(4): 515 - 522.
[Abstract] [Full Text] [PDF]
J. Zhang, T.-X. Xu, P. J. Hallett, M. Watanabe, S. G. N. Grant, O. Isacson, and W.-D. Yao
PSD-95 Uncouples Dopamine-Glutamate Interaction in the D1/PSD-95/NMDA Receptor Complex
J. Neurosci., March 4, 2009; 29(9): 2948 - 2960.
[Abstract] [Full Text] [PDF]
A. Munoz, Q. Li, F. Gardoni, E. Marcello, C. Qin, T. Carlsson, D. Kirik, M. Di Luca, A. Bjorklund, E. Bezard, et al.
Combined 5-HT1A and 5-HT1B receptor agonists for the treatment of L-DOPA-induced dyskinesia
Brain, December 1, 2008; 131(12): 3380 - 3394.
[Abstract] [Full Text] [PDF]
Y. Zhang, D. V. Venkitaramani, C. M. Gladding, Y. Zhang, P. Kurup, E. Molnar, G. L. Collingridge, and P. J. Lombroso
The Tyrosine Phosphatase STEP Mediates AMPA Receptor Endocytosis after Metabotropic Glutamate Receptor Stimulation
J. Neurosci., October 15, 2008; 28(42): 10561 - 10566.
[Abstract] [Full Text] [PDF]
H. Tong and A. J. Gibb
Dopamine D1 receptor inhibition of NMDA receptor currents mediated by tyrosine kinase-dependent receptor trafficking in neonatal rat striatum
J. Physiol., October 1, 2008; 586(19): 4693 - 4707.
[Abstract] [Full Text] [PDF]
J. Xu, M. Weerapura, M. K. Ali, M. F. Jackson, H. Li, G. Lei, S. Xue, C. L. Kwan, M. F. Manolson, K. Yang, et al.
Control of Excitatory Synaptic Transmission by C-terminal Src Kinase
J. Biol. Chem., June 20, 2008; 283(25): 17503 - 17514.
[Abstract] [Full Text] [PDF]
X. Sun, M. Milovanovic, Y. Zhao, and M. E. Wolf
Acute and Chronic Dopamine Receptor Stimulation Modulates AMPA Receptor Trafficking in Nucleus Accumbens Neurons Cocultured with Prefrontal Cortex Neurons
J. Neurosci., April 16, 2008; 28(16): 4216 - 4230.
[Abstract] [Full Text] [PDF]
C. Zeng, I. Armando, Y. Luo, G. M. Eisner, R. A. Felder, and P. A. Jose
Dysregulation of dopamine-dependent mechanisms as a determinant of hypertension: studies in dopamine receptor knockout mice
Am J Physiol Heart Circ Physiol, February 1, 2008; 294(2): H551 - H569.
[Abstract] [Full Text] [PDF]
S. Zhang, L. Edelmann, J. Liu, J. E. Crandall, and M. A. Morabito
Cdk5 Regulates the Phosphorylation of Tyrosine 1472 NR2B and the Surface Expression of NMDA Receptors
J. Neurosci., January 9, 2008; 28(2): 415 - 424.
[Abstract] [Full Text] [PDF]
R. Jurd, C. Thornton, J. Wang, K. Luong, K. Phamluong, V. Kharazia, S. L. Gibb, and D. Ron
Mind Bomb-2 Is an E3 Ligase That Ubiquitinates the N-Methyl-D-aspartate Receptor NR2B Subunit in a Phosphorylation-dependent Manner
J. Biol. Chem., January 4, 2008; 283(1): 301 - 310.
[Abstract] [Full Text] [PDF]
J. Kim, S. Lee, K. Park, I. Hong, B. Song, G. Son, H. Park, W. R. Kim, E. Park, H. K. Choe, et al.
Amygdala depotentiation and fear extinction
PNAS, December 26, 2007; 104(52): 20955 - 20960.
[Abstract] [Full Text] [PDF]
C. H. Large
Do NMDA receptor antagonist models of schizophrenia predict the clinical efficacy of antipsychotic drugs?
J Psychopharmacol, May 1, 2007; 21(3): 283 - 301.
[Abstract] [PDF]
M. M. Y. Fan, H. B. Fernandes, L. Y. J. Zhang, M. R. Hayden, and L. A. Raymond
Altered NMDA Receptor Trafficking in a Yeast Artificial Chromosome Transgenic Mouse Model of Huntington's Disease
J. Neurosci., April 4, 2007; 27(14): 3768 - 3779.
[Abstract] [Full Text] [PDF]
B. Schilstrom, R. Yaka, E. Argilli, N. Suvarna, J. Schumann, B. T. Chen, M. Carman, V. Singh, W. S. Mailliard, D. Ron, et al.
Cocaine Enhances NMDA Receptor-Mediated Currents in Ventral Tegmental Area Cells via Dopamine D5 Receptor-Dependent Redistribution of NMDA Receptors.
J. Neurosci., August 15, 2006; 26(33): 8549 - 8558.
[Abstract] [Full Text] [PDF]
X. Wang, F. Wang, L. Arterburn, R. Wollmann, and J. Ma
The Interaction between Cytoplasmic Prion Protein and the Hydrophobic Lipid Core of Membrane Correlates with Neurotoxicity
J. Biol. Chem., May 12, 2006; 281(19): 13559 - 13565.
[Abstract] [Full Text] [PDF]
C. Cepeda and M. S. Levine
Where Do You Think You Are Going? The NMDA-D1 Receptor Trap
Sci. Signal., May 2, 2006; 2006(333): pe20 - pe20.
[Abstract] [Full Text] [PDF]
P. J. Hallett, R. Spoelgen, B. T. Hyman, D. G. Standaert, and A. W. Dunah
Dopamine D1 activation potentiates striatal NMDA receptors by tyrosine phosphorylation-dependent subunit trafficking.
J. Neurosci., April 26, 2006; 26(17): 4690 - 4700.
[Abstract] [Full Text] [PDF]
F. Gardoni, B. Picconi, V. Ghiglieri, F. Polli, V. Bagetta, G. Bernardi, F. Cattabeni, M. Di Luca, and P. Calabresi
A critical interaction between NR2B and MAGUK in L-DOPA induced dyskinesia.
J. Neurosci., March 15, 2006; 26(11): 2914 - 2922.
[Abstract] [Full Text] [PDF]
C. Fiorentini, M. C. Rizzetti, C. Busi, S. Bontempi, G. Collo, P. Spano, and C. Missale
Loss of Synaptic D1 Dopamine/N-Methyl-D-aspartate Glutamate Receptor Complexes in L-DOPA-Induced Dyskinesia in the Rat
Mol. Pharmacol., March 1, 2006; 69(3): 805 - 812.
[Abstract] [Full Text] [PDF]
C. R. Yang and L. Chen
Targeting Prefrontal Cortical Dopamine D1 and N-Methyl-D-Aspartate Receptor Interactions in Schizophrenia Treatment
Neuroscientist, October 1, 2005; 11(5): 452 - 470.
[Abstract] [PDF]
J. G. Truong, D. G. Wilkins, J. Baudys, D. J. Crouch, K. L. Johnson-Davis, J. W. Gibb, G. R. Hanson, and A. E. Fleckenstein
Age-Dependent Methamphetamine-Induced Alterations in Vesicular Monoamine Transporter-2 Function: Implications for Neurotoxicity
J. Pharmacol. Exp. Ther., September 1, 2005; 314(3): 1087 - 1092.
[Abstract] [Full Text] [PDF]
K. Ferrani-Kile and S. W. Leslie
Modulation of Protein Tyrosine Phosphatase Activity Alters the Subunit Assembly in Native N-Methyl-D-aspartate Receptor Complex
J. Pharmacol. Exp. Ther., July 1, 2005; 314(1): 86 - 93.
[Abstract] [Full Text] [PDF]
M. Wittmann, M. J. Marino, D. A. Henze, G. R. Seabrook, and P. J. Conn
Clozapine Potentiation of N-Methyl-D-aspartate Receptor Currents in the Nucleus Accumbens: Role of NR2B and Protein Kinase A/Src Kinases
J. Pharmacol. Exp. Ther., May 1, 2005; 313(2): 594 - 603.
[Abstract] [Full Text] [PDF]
K. Y. Tseng and P. O'Donnell
Post-pubertal Emergence of Prefrontal Cortical Up States Induced by D1-NMDA Co-activation
Cereb Cortex, January 1, 2005; 15(1): 49 - 57.
[Abstract] [Full Text] [PDF]
M. Townsend, Y. Liu, and M. Constantine-Paton
Retina-Driven Dephosphorylation of the NR2A Subunit Correlates with Faster NMDA Receptor Kinetics at Developing Retinocollicular Synapses
J. Neurosci., December 8, 2004; 24(49): 11098 - 11107.
[Abstract] [Full Text] [PDF]
D. Ron
Signaling Cascades Regulating NMDA Receptor Sensitivity to Ethanol
Neuroscientist, August 1, 2004; 10(4): 325 - 336.
[Abstract] [PDF]
B. Picconi, F. Gardoni, D. Centonze, D. Mauceri, M. A. Cenci, G. Bernardi, P. Calabresi, and M. Di Luca
Abnormal Ca2+-Calmodulin-Dependent Protein Kinase II Function Mediates Synaptic and Motor Deficits in Experimental Parkinsonism
J. Neurosci., June 9, 2004; 24(23): 5283 - 5291.
[Abstract] [Full Text] [PDF]
K. Y. Tseng and P. O'Donnell
Dopamine-Glutamate Interactions Controlling Prefrontal Cortical Pyramidal Cell Excitability Involve Multiple Signaling Mechanisms
J. Neurosci., June 2, 2004; 24(22): 5131 - 5139.
[Abstract] [Full Text] [PDF]
C. Kamm, H. Boston, J. Hewett, J. Wilbur, D. P. Corey, P. I. Hanson, V. Ramesh, and X. O. Breakefield
The Early Onset Dystonia Protein TorsinA Interacts with Kinesin Light Chain 1
J. Biol. Chem., May 7, 2004; 279(19): 19882 - 19892.
[Abstract] [Full Text] [PDF]
K. Prybylowski and R. J. Wenthold
N-Methyl-D-aspartate Receptors: Subunit Assembly and Trafficking to the Synapse
J. Biol. Chem., March 12, 2004; 279(11): 9673 - 9676.
[Full Text] [PDF]
A. W. Dunah, A. C. Sirianni, A. A. Fienberg, E. Bastia, M. A. Schwarzschild, and David. G. Standaert
Dopamine D1-Dependent Trafficking of Striatal N-Methyl-D-aspartate Glutamate Receptors Requires Fyn Protein Tyrosine Kinase but Not DARPP-32
Mol. Pharmacol., January 1, 2004; 65(1): 121 - 129.
[Abstract] [Full Text] [PDF]
D. G. Standaert
Introduction: Adenosine A2A receptor modulation of motor systems for symptomatic therapy in Parkinson's disease
Neurology, December 9, 2003; 61(90116): S30 - 31.
[Full Text]
Y. Ishikawa, H. Katoh, and M. Negishi
A Role of Rnd1 GTPase in Dendritic Spine Formation in Hippocampal Neurons
J. Neurosci., December 3, 2003; 23(35): 11065 - 11072.
[Abstract] [Full Text] [PDF]
X. Wang, P. Zhong, Z. Gu, and Z. Yan
Regulation of NMDA Receptors by Dopamine D4 Signaling in Prefrontal Cortex
J. Neurosci., October 29, 2003; 23(30): 9852 - 9861.
[Abstract] [Full Text] [PDF]
C. Thornton, R. Yaka, S. Dinh, and D. Ron
H-Ras Modulates N-Methyl-D-aspartate Receptor Function via Inhibition of Src Tyrosine Kinase Activity
J. Biol. Chem., June 20, 2003; 278(26): 23823 - 23829.
[Abstract] [Full Text] [PDF]
R. M. Alvestad, D. R. Grosshans, S. J. Coultrap, T. Nakazawa, T. Yamamoto, and M. D. Browning
Tyrosine Dephosphorylation and Ethanol Inhibition of N-Methyl-D-aspartate Receptor Function
J. Biol. Chem., March 21, 2003; 278(13): 11020 - 11025.
[Abstract] [Full Text] [PDF]
J. Flores-Hernandez, C. Cepeda, E. Hernandez-Echeagaray, C. R. Calvert, E. S. Jokel, A. A. Fienberg, P. Greengard, and M. S. Levine
Dopamine Enhancement of NMDA Currents in Dissociated Medium-Sized Striatal Neurons: Role of D1 Receptors and DARPP-32
J Neurophysiol, December 1, 2002; 88(6): 3010 - 3020.
[Abstract] [Full Text] [PDF]
K. Prybylowski, Z. Fu, G. Losi, L. M. Hawkins, J. Luo, K. Chang, R. J. Wenthold, and S. Vicini
Relationship between Availability of NMDA Receptor Subunits and Their Expression at the Synapse
J. Neurosci., October 15, 2002; 22(20): 8902 - 8910.
[Abstract] [Full Text] [PDF]
D. R. Grosshans, D. A. Clayton, S. J. Coultrap, and M. D. Browning
Analysis of Glutamate Receptor Surface Expression in Acute Hippocampal Slices
Sci. Signal., June 18, 2002; 2002(137): pl8 - pl8.
[Abstract] [Full Text] [PDF]
L. Chen and C. R. Yang
Interaction of Dopamine D1 and NMDA Receptors Mediates Acute Clozapine Potentiation of Glutamate EPSPs in Rat Prefrontal Cortex
J Neurophysiol, May 1, 2002; 87(5): 2324 - 2336.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|