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The Journal of Neuroscience, September 1, 2001, 21(17):6874-6888

Dendritic Arborizations of the Rat Substantia Nigra Pars Reticulata Neurons: Spatial Organization and Relation to the Lamellar Compartmentation of Striato-Nigral Projections

P. Mailly², S. Charpier¹, S. Mahon¹, A. Menetrey¹, A. M. Thierry¹, J. Glowinski¹, and J. M. Deniau¹

¹ Institut National de la Santé et de la Recherche Médicale U 114, Chaire de Neuropharmacologie, Collège de France, 75231 Paris Cedex 05, France, and ² Neurobiologie des Processus Adaptatifs-Neurobiologie des Signaux Intercellulaires, Centre National de la Recherche Scientifique, Université Pierre et Marie Curie, 75005 Paris France

The cerebral cortex provides a major source of inputs to the basal ganglia. As has been well documented, the topography of corticostriatal projections subdivides the striatum into a mosaic of functionally distinct sectors. How information flow from these striatal sectors remains segregated or not within basal ganglia output nuclei has to be established.

Electrophysiologically identified neurons of the rat substantia nigra pars reticulata were labeled by juxtacellular injection of Neurobiotin, and the spatial organization of their dendritic arborizations was analyzed in relation to the projection fields of individual striatal sectors. Thirty-nine nigral neurons located in the projection territory of the distinct striatal sensorimotor sectors were reconstructed. The data show that the dendritic arborizations of nigral neurons conform to the geometry of striato-nigral projections. Like striatal projections, the arborizations formed a series of curved laminas enveloping a dorsolaterally located core. Although dendritic fields of the neurons lying in the laminae were flat, those located in the core were spherical or cylindrical, thereby conforming to the shape of the striatal projection fields. This remarkable alignment between the dendritic arborizations of nigral neurons and the projection fields from individual striatal districts supports the concept of a parallel architecture of the striato-nigral circuits. However, pars reticulata neurons usually extend part of their dendrites within adjacent striatal projection fields, thereby ensuring a continuum between channels. The extension of the dendritic arborizations within the striatal projection fields suggests that nigral neurons integrate the information that is relevant for the completion of the specific motor behavior they control.

Key words: substantia nigra pars reticulata; dendritic fields; juxtacellular injection; functional compartmentation of the basal ganglia; three-dimensional reconstruction; striato-nigral projections

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Copyright © 2001 Society for Neuroscience  0270-6474/01/21176874-15$05.00/0

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