QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (47) Citing Articles via Google Scholar Google Scholar Articles by Fenu, S. Articles by Di Chiara, G. Search for Related Content PubMed PubMed Citation Articles by Fenu, S. Articles by Di Chiara, G.

 Previous Article  |  Next Article 

The Journal of Neuroscience, September 1, 2001, 21(17):6897-6904

A Role for Dopamine D1 Receptors of the Nucleus Accumbens Shell in Conditioned Taste Aversion Learning

Sandro Fenu, Valentina Bassareo, and Gaetano Di Chiara

Department of Toxicology and Consiglio Nazionale delle Ricerche, Center for Neuropharmacology, University of Cagliari, 09126 Cagliari, Italy

The involvement of dopamine (DA) in conditioned taste aversion (CTA) learning was studied with saccharin or sucrose as the conditioned stimulus (CS) and intraperitoneal lithium as the unconditioned stimulus (US). The dopamine D₁ antagonist R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride (SCH 23390) (12.5-50 µg/kg, s.c.), given 5 min after the CS, impaired the acquisition of CTA in a paradigm consisting of three or a single CS-lithium association. SCH 23390 failed to impair CTA acquisition given 45 min after, 30 min before, or right before the CS. ()-trans-6,7,7a,8,9,13b-hexahydro-3-chloro-2-hydroxy-N-methyl-5a-benzo-(D)-naphtho-(2,1b) azepine (SCH 39166) (12.5-50.0 µg/kg, s.c), a SCH 23390 analog that does not bind to 5HT₂ receptors, also impaired CTA. No significant impairment of CTA was obtained after administration of the specific D₂/D₃ antagonist raclopride (100 and 300 µg/kg, s.c.). The ability of SCH 23390 to impair CTA learning was confirmed by its ability to reduce the conditional aversive reactions to a gustatory CS (sweet chocolate) as estimated in a taste reactivity paradigm. SCH 39166 impaired CTA also when infused in the nucleus accumbens (NAc) shell 5 min after the CS. No impairment was obtained from the NAc core or from the bed nucleus stria terminalis. The results indicate that D₁ receptor blockade impairs CTA learning by disrupting the formation of a short-term memory trace of the gustatory CS and that endogenous dopamine acting on D₁ receptors in the NAc shell plays a role in short-term memory processes related to associative gustatory learning.

Key words: dopamine; D₁ receptors; nucleus accumbens shell; conditioned taste aversion; short-term memory; SCH 23390; SCH 39166; lithium chloride

---

Copyright © 2001 Society for Neuroscience  0270-6474/01/21176897-08$05.00/0

This article has been cited by other articles:

				S. Jonkman and B. J. Everitt Post-learning infusion of anisomycin into the anterior cingulate cortex impairs instrumental acquisition through an effect on reinforcer valuation Learn. Mem., October 28, 2009; 16(11): 706 - 713. [Abstract] [Full Text] [PDF]

				S. R. Laviolette, N. M. Lauzon, S. F. Bishop, N. Sun, and H. Tan Dopamine Signaling through D1-Like versus D2-Like Receptors in the Nucleus Accumbens Core versus Shell Differentially Modulates Nicotine Reward Sensitivity J. Neurosci., August 6, 2008; 28(32): 8025 - 8033. [Abstract] [Full Text] [PDF]

				Y.-C. Kim, H.-G. Lee, and K.-A. Han D1 Dopamine Receptor dDA1 Is Required in the Mushroom Body Neurons for Aversive and Appetitive Learning in Drosophila J. Neurosci., July 18, 2007; 27(29): 7640 - 7647. [Abstract] [Full Text] [PDF]

				L. Ramirez-Lugo, L. Nunez-Jaramillo, and F. Bermudez-Rattoni Taste Memory Formation: Role of Nucleus Accumbens Chem Senses, January 1, 2007; 32(1): 93 - 97. [Abstract] [Full Text] [PDF]

				L. Ramirez-Lugo, S. Zavala-Vega, and F. Bermudez-Rattoni NMDA and muscarinic receptors of the nucleus accumbens have differential effects on taste memory formation Learn. Mem., January 1, 2006; 13(1): 45 - 51. [Abstract] [Full Text] [PDF]

				L. Becerra, M. Iadarola, and D. Borsook CNS Activation by Noxious Heat to the Hand or Foot: Site-Dependent Delay in Sensory But Not Emotion Circuitry J Neurophysiol, January 1, 2004; 91(1): 533 - 541. [Abstract] [Full Text] [PDF]

				M. Barrot, J. D. A. Olivier, L. I. Perrotti, R. J. DiLeone, O. Berton, A. J. Eisch, S. Impey, D. R. Storm, R. L. Neve, J. C. Yin, et al. CREB activity in the nucleus accumbens shell controls gating of behavioral responses to emotional stimuli PNAS, August 20, 2002; 99(17): 11435 - 11440. [Abstract] [Full Text] [PDF]

				R. G. Mair, J. K. Koch, J. B. Newman, J. R. Howard, and J. A. Burk A Double Dissociation within Striatum between Serial Reaction Time and Radial Maze Delayed Nonmatching Performance in Rats J. Neurosci., August 1, 2002; 22(15): 6756 - 6765. [Abstract] [Full Text] [PDF]

				V. Bassareo, M. A. De Luca, and G. Di Chiara Differential Expression of Motivational Stimulus Properties by Dopamine in Nucleus Accumbens Shell versus Core and Prefrontal Cortex J. Neurosci., June 1, 2002; 22(11): 4709 - 4719. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help