WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (21)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Monsivais, P.
Right arrow Articles by Rubel, E. W
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Monsivais, P.
Right arrow Articles by Rubel, E. W

 Previous Article  |  Next Article 

The Journal of Neuroscience, October 1, 2001, 21(19):7823-7830

Accommodation Enhances Depolarizing Inhibition in Central Neurons

Pablo Monsivais and Edwin W Rubel

Graduate Program in Neurobiology and Behavior and Virginia Merrill Bloedel Hearing Research Center, University of Washington, Seattle, Washington 98195

Neurons in the avian cochlear nucleus are depolarized by GABAergic synaptic input. We recorded GABAergic synaptic currents using the gramicidin-perforated-patch method and found their reversal potential (Vrev) to be depolarized relative to spike threshold, which is surprising given that these inputs are inhibitory. Depolarizing IPSPs (dIPSPs) are kept below spike generation threshold by the activation of a dendrotoxin-I-sensitive, voltage-gated K+ conductance. We show experimentally that the polarity of IPSPs contributes to their efficacy; dIPSPs induce accommodation, the positive shift in spike threshold, and are therefore more strongly inhibitory than conventional, hyperpolarizing IPSPs in the same neurons. A similar inhibitory mechanism has been described in invertebrate sensory fibers and axons of dorsal root ganglion cells and may be a general means of amplifying the strength of inhibition in cases where the size of excitatory conductances greatly exceeds that of inhibitory conductances.

Key words: inhibition; GABA; magnocellularis; dynamic clamp; PAD; accommodation; auditory

Copyright © 2001 Society for Neuroscience  0270-6474/01/21197823-08$05.00/0


This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
Z.-Q. Tang, H. Gao, and Y. Lu
Control of a Depolarizing GABAergic Input in an Auditory Coincidence Detection Circuit
J Neurophysiol, September 1, 2009; 102(3): 1672 - 1683.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
S. P. Kuo, L. A. Bradley, and L. O. Trussell
Heterogeneous Kinetics and Pharmacology of Synaptic Inhibition in the Chick Auditory Brainstem
J. Neurosci., July 29, 2009; 29(30): 9625 - 9634.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
M. Zhang, K. Clarke, H. Zhong, C. Vollmer, and C. A. Nurse
Postsynaptic action of GABA in modulating sensory transmission in co-cultures of rat carotid body via GABAA receptors
J. Physiol., January 15, 2009; 587(2): 329 - 344.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. S. Kuznetsova, M. H. Higgs, and W. J. Spain
Adaptation of Firing Rate and Spike-Timing Precision in the Avian Cochlear Nucleus
J. Neurosci., November 12, 2008; 28(46): 11906 - 11915.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
D. C. Peterson, S. Voytenko, D. Gans, A. Galazyuk, and J. Wenstrup
Intracellular Recordings From Combination-Sensitive Neurons in the Inferior Colliculus
J Neurophysiol, August 1, 2008; 100(2): 629 - 645.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
Y. Ben-Ari, J.-L. Gaiarsa, R. Tyzio, and R. Khazipov
GABA: A Pioneer Transmitter That Excites Immature Neurons and Generates Primitive Oscillations
Physiol Rev, October 1, 2007; 87(4): 1215 - 1284.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
I. Milenkovic, M. Witte, R. Turecek, M. Heinrich, T. Reinert, and R. Rubsamen
Development of Chloride-Mediated Inhibition in Neurons of the Anteroventral Cochlear Nucleus of Gerbil (Meriones unguiculatus)
J Neurophysiol, September 1, 2007; 98(3): 1634 - 1644.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
M. A. Howard, R. M. Burger, and E. W Rubel
A Developmental Switch to GABAergic Inhibition Dependent on Increases in Kv1-Type K+ Currents
J. Neurosci., February 21, 2007; 27(8): 2112 - 2123.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
Y. Lu
Endogenous mGluR Activity Suppresses GABAergic Transmission in Avian Cochlear Nucleus Magnocellularis Neurons
J Neurophysiol, February 1, 2007; 97(2): 1018 - 1029.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
V. K. Dasika, J. A. White, L. H. Carney, and H. S. Colburn
Effects of Inhibitory Feedback in a Network Model of Avian Brain Stem
J Neurophysiol, July 1, 2005; 94(1): 400 - 414.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
Y. Lu, R. M. Burger, and E. W Rubel
GABAB Receptor Activation Modulates GABAA Receptor-Mediated Inhibition in Chicken Nucleus Magnocellularis Neurons
J Neurophysiol, March 1, 2005; 93(3): 1429 - 1438.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
H. M Brew, J. L Hallows, and B. L Tempel
Hyperexcitability and reduced low threshold potassium currents in auditory neurons of mice lacking the channel subunit Kv1.1
J. Physiol., April 1, 2003; 548(1): 1 - 20.
[Abstract] [Full Text] [PDF]


-
-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2009 by Society for Neuroscience ONLINE ISSN: 1529-2401
-