 |
||||
|
||||
|
||||
|
||||
Previous Article | Next Article
The Journal of Neuroscience, January 15, 2001, 21(2):550-558
Neuronal Cyclin-Dependent Kinase 5 Activity Is Critical for Survival
Teruyuki Tanaka1, 2, Veeranna3, Toshio Ohshima1, 2, Prithi Rajan4, Niranjana D. Amin3, Andrew Cho1, Taduru Sreenath1, Harish C. Pant3, Roscoe O. Brady2, and Ashok B. Kulkarni1 1 Functional Genomics Unit, Gene Targeting Facility, National Institute of Dental and Craniofacial Research, and 2 Developmental and Metabolic Neurology Branch, 3 Laboratory of Neurochemistry, and 4 Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892
Cyclin-dependent kinase 5 (Cdk5) null mice exhibit a unique phenotype characterized by perinatal mortality, disrupted cerebral cortical layering attributable to abnormal neuronal migration, lack of cerebellar foliation, and chromatolytic changes of neurons in the brainstem and the spinal cord. Because Cdk5 is expressed in both neurons and astrocytes, it has been unclear whether this phenotype is primarily attributable to defects in neurons or in astrocytes. Herein we report reconstitution of Cdk5 expression in neurons in Cdk5 null mice and its effect on the null phenotype. Unlike the Cdk5 null mice, the reconstituted Cdk5 null mice that express the Cdk5 transgene under the p35 promoter (TgKO mice) were viable and fertile. Because Cdk5 expression is mainly limited to neurons in these mice and rescues the defects in the nervous system of the Cdk5 null phenotype, it clearly demonstrates that Cdk5 activity is necessary for normal development and survival of p35-expressing neurons.
Key words: Cdk5; cerebrum; cerebellum; neuron; astrocyte; phosphorylation; neurodegeneration; transgenic mice
Copyright © 2001 Society for Neuroscience 0270-6474/01/212550-09$05.00/0
This article has been cited by other articles:
R. Liu, B. Tian, M. Gearing, S. Hunter, K. Ye, and Z. Mao
Cdk5-mediated regulation of the PIKE-A-Akt pathway and glioblastoma cell invasion
PNAS, May 27, 2008; 105(21): 7570 - 7575.
[Abstract] [Full Text] [PDF]
Y. Hirota, T. Ohshima, N. Kaneko, M. Ikeda, T. Iwasato, A. B. Kulkarni, K. Mikoshiba, H. Okano, and K. Sawamoto
Cyclin-Dependent Kinase 5 Is Required for Control of Neuroblast Migration in the Postnatal Subventricular Zone
J. Neurosci., November 21, 2007; 27(47): 12829 - 12838.
[Abstract] [Full Text] [PDF]
Y.-L. Zheng, B.-S. Li, J. Kanungo, S. Kesavapany, N. Amin, P. Grant, and H. C. Pant
Cdk5 Modulation of Mitogen-activated Protein Kinase Signaling Regulates Neuronal Survival
Mol. Biol. Cell, February 1, 2007; 18(2): 404 - 413.
[Abstract] [Full Text] [PDF]
C. J. Strock, J.-I. Park, E. K. Nakakura, G. S. Bova, J. T. Isaacs, D. W. Ball, and B. D. Nelkin
Cyclin-dependent kinase 5 activity controls cell motility and metastatic potential of prostate cancer cells.
Cancer Res., August 1, 2006; 66(15): 7509 - 7515.
[Abstract] [Full Text] [PDF]
T. K. Pareek, J. Keller, S. Kesavapany, H. C. Pant, M. J. Iadarola, R. O. Brady, and A. B. Kulkarni
Cyclin-dependent kinase 5 activity regulates pain signaling
PNAS, January 17, 2006; 103(3): 791 - 796.
[Abstract] [Full Text] [PDF]
D. R. Ledee, C. Y. Gao, R. Seth, R. N. Fariss, B. K. Tripathi, and P. S. Zelenka
A Specific Interaction between Muskelin and the Cyclin-dependent Kinase 5 Activator p39 Promotes Peripheral Localization of Muskelin
J. Biol. Chem., June 3, 2005; 280(22): 21376 - 21383.
[Abstract] [Full Text] [PDF]
X. Tang, X. Wang, X. Gong, M. Tong, D. Park, Z. Xia, and Z. Mao
Cyclin-Dependent Kinase 5 Mediates Neurotoxin-Induced Degradation of the Transcription Factor Myocyte Enhancer Factor 2
J. Neurosci., May 11, 2005; 25(19): 4823 - 4834.
[Abstract] [Full Text] [PDF]
S. Takahashi, T. Ohshima, A. Cho, T. Sreenath, M. J. Iadarola, H. C. Pant, Y. Kim, A. C. Nairn, R. O. Brady, P. Greengard, et al.
Increased activity of cyclin-dependent kinase 5 leads to attenuation of cocaine-mediated dopamine signaling
PNAS, February 1, 2005; 102(5): 1737 - 1742.
[Abstract] [Full Text] [PDF]
L. S. Patel, H. J. Wenzel, and P. A. Schwartzkroin
Physiological and Morphological Characterization of Dentate Granule Cells in the p35 Knock-Out Mouse Hippocampus: Evidence for an Epileptic Circuit
J. Neurosci., October 13, 2004; 24(41): 9005 - 9014.
[Abstract] [Full Text] [PDF]
S. Kesavapany, N. Amin, Y.-L. Zheng, R. Nijhara, H. Jaffe, R. Sihag, J. S. Gutkind, S. Takahashi, A. Kulkarni, P. Grant, et al.
p35/Cyclin-Dependent Kinase 5 Phosphorylation of Ras Guanine Nucleotide Releasing Factor 2 (RasGRF2) Mediates Rac-Dependent Extracellular Signal-Regulated Kinase 1/2 Activity, Altering RasGRF2 and Microtubule-Associated Protein 1b Distribution in Neurons
J. Neurosci., May 5, 2004; 24(18): 4421 - 4431.
[Abstract] [Full Text] [PDF]
M. Hirasawa, T. Ohshima, S. Takahashi, G. Longenecker, Y. Honjo, Veeranna, H. C. Pant, K. Mikoshiba, R. O. Brady, and A. B. Kulkarni
Perinatal abrogation of Cdk5 expression in brain results in neuronal migration defects
PNAS, April 20, 2004; 101(16): 6249 - 6254.
[Abstract] [Full Text] [PDF]
T. B. Shea, J. T. Yabe, D. Ortiz, A. Pimenta, P. Loomis, R. D. Goldman, N. Amin, and H. C. Pant
Cdk5 regulates axonal transport and phosphorylation of neurofilaments in cultured neurons
J. Cell Sci., February 22, 2004; 117(6): 933 - 941.
[Abstract] [Full Text] [PDF]
S. Y. Lee, M. R. Wenk, Y. Kim, A. C. Nairn, and P. De Camilli
Regulation of synaptojanin 1 by cyclin-dependent kinase 5 at synapses
PNAS, January 13, 2004; 101(2): 546 - 551.
[Abstract] [Full Text] [PDF]
B.-S. Li, W. Ma, H. Jaffe, Y. Zheng, S. Takahashi, L. Zhang, A. B. Kulkarni, and H. C. Pant
Cyclin-dependent Kinase-5 Is Involved in Neuregulin-dependent Activation of Phosphatidylinositol 3-Kinase and Akt Activity Mediating Neuronal Survival
J. Biol. Chem., September 12, 2003; 278(37): 35702 - 35709.
[Abstract] [Full Text] [PDF]
S. Kesavapany, K.-F. Lau, S. Ackerley, S. J. Banner, S. J. A. Shemilt, J. D. Cooper, P. N. Leigh, C. E. Shaw, D. M. McLoughlin, and C. C. J. Miller
Identification of a Novel, Membrane-Associated Neuronal Kinase, Cyclin-Dependent Kinase 5/p35-Regulated Kinase
J. Neurosci., June 15, 2003; 23(12): 4975 - 4983.
[Abstract] [Full Text] [PDF]
T. Ohshima, M. Ogawa, K. Takeuchi, S. Takahashi, A. B. Kulkarni, and K. Mikoshiba
Cyclin-Dependent Kinase 5/p35 Contributes Synergistically with Reelin/Dab1 to the Positioning of Facial Branchiomotor and Inferior Olive Neurons in the Developing Mouse Hindbrain
J. Neurosci., May 15, 2002; 22(10): 4036 - 4044.
[Abstract] [Full Text] [PDF]
S. Ross, A. Tienhaara, M.-S. Lee, L.-H. Tsai, and G. Gill
GC Box-binding Transcription Factors Control the Neuronal Specific Transcription of the Cyclin-dependent Kinase 5 Regulator p35
J. Biol. Chem., February 1, 2002; 277(6): 4455 - 4464.
[Abstract] [Full Text] [PDF]
B.-S. Li, M.-K. Sun, L. Zhang, S. Takahashi, W. Ma, L. Vinade, A. B. Kulkarni, R. O. Brady, and H. C. Pant
Regulation of NMDA receptors by cyclin-dependent kinase-5
PNAS, September 26, 2001; (2001) 211428098.
[Abstract] [Full Text] [PDF]
J. Ko, S. Humbert, R. T. Bronson, S. Takahashi, A. B. Kulkarni, E. Li, and L.-H. Tsai
p35 and p39 Are Essential for Cyclin-Dependent Kinase 5 Function during Neurodevelopment
J. Neurosci., September 1, 2001; 21(17): 6758 - 6771.
[Abstract] [Full Text] [PDF]
B.-S. Li, M.-K. Sun, L. Zhang, S. Takahashi, W. Ma, L. Vinade, A. B. Kulkarni, R. O. Brady, and H. C. Pant
From the Cover: Regulation of NMDA receptors by cyclin-dependent kinase-5
PNAS, October 23, 2001; 98(22): 12742 - 12747.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|