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The Journal of Neuroscience, January 15, 2001, 21(2):713-725
Reliability of Macaque Frontal Eye Field Neurons Signaling
Saccade Targets during Visual Search
Narcisse P.
Bichot1,
Kirk G.
Thompson2,
S.
Chenchal
Rao3, and
Jeffrey D.
Schall3
1 Laboratory of Neuropsychology, National Institute of
Mental Health, National Institutes of Health, Bethesda, Maryland 20892, 2 Laboratory of Sensorimotor Research, National Eye
Institute, National Institutes of Health, Bethesda, Maryland 20892, and
3 Vanderbilt Vision Research Center, Department of
Psychology, Vanderbilt University, Nashville, Tennessee 37240
Although many studies have explored the neural correlates of visual
attention and selection, few have examined the reliability with which
neurons represent relevant information. We monitored activity in the
frontal eye field (FEF) of monkeys trained to make a saccade to a
target defined by the conjunction of color and shape or to a target
defined by color differences. The difficulty of conjunction search was
manipulated by varying the number of distractors, and the difficulty
of feature search was manipulated by varying the similarity in
color between target and distractors. The reliability of individual
neurons in signaling the target location in correct trials was
determined using a neuron anti-neuron approach within a
winner-take-all architecture. On average, approximately seven trials of
the activity of single neurons were sufficient to match near-perfect
behavioral performance in the easiest search, and ~14 trials were
sufficient in the most difficult search. We also determined how
many neurons recorded separately need to be evaluated within a trial to
match behavioral performance. Results were quantitatively similar to
those of the single neuron analysis. We also found that signal
reliability in the FEF did not change with task demands, and overall,
behavioral accuracy across the search tasks was approximated when only
six trials or neurons were combined. Furthermore, whether combining
trials or neurons, the increase in time of target discrimination
corresponded to the increase in mean saccade latency across visual
search difficulty levels. Finally, the variance of spike counts in the
FEF increased as a function of the mean spike count, and the parameters
of this relationship did not change with attentional selection.
Key words:
oculomotor; visual cortex; vision; attention; eye
movements; selection; model
Copyright © 2001 Society for Neuroscience 0270-6474/01/212713-13$05.00/0
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