 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, November 1, 2001, 21(21):8426-8434
Distinct Roles for the Two Rho GDP/GTP Exchange Factor Domains of Kalirin in Regulation of Neurite Growth and Neuronal Morphology
Peter Penzes1, Richard C. Johnson1, Vikram Kambampati1, Richard E. Mains2, and Betty A. Eipper2 1 Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, and 2 Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030
The actin cytoskeleton, essential for neuronal development, is regulated in part by small GTP binding proteins of the Rho subfamily. Kalirin-9, with two Rho subfamily-specific GDP/GTP exchange factor (GEF) domains, localizes to neurites and growth cones of primary cortical neurons. Kalirin-9 overexpression in cultured cortical neurons induces longer neurites and altered neuronal morphology. Expression of the first GEF domain alone results in drastically shortened axons and excessive growth cones, mediated by Rac1. Expression of the second GEF domain alone induces axonal over-elongation and abundant filopodial neurites, mediated by RhoA. Coordination of the actions of the individual GEF domains through their presence in Kalirin-9, with its Sec14p, spectrin, and Src homology domain 3 motifs, is essential for regulating neurite extension and neuronal morphology.
Key words: Rac1; RhoA; Trio; spectrin; cytoskeleton; growth cone
Copyright © 2001 Society for Neuroscience 0270-6474/01/21218426-09$05.00/0
This article has been cited by other articles:
M.-F. Lise, D. P. Srivastava, P. Arstikaitis, R. L. Lett, R. Sheta, V. Viswanathan, P. Penzes, T. P. O'Connor, and A. El-Husseini
Myosin-Va-interacting protein, RILPL2, controls cell shape and neuronal morphogenesis via Rac signaling
J. Cell Sci., October 15, 2009; 122(20): 3810 - 3821.
[Abstract] [Full Text] [PDF]
M. E. Cahill, Z. Xie, M. Day, H. Photowala, M. V. Barbolina, C. A. Miller, C. Weiss, J. Radulovic, J. D. Sweatt, J. F. Disterhoft, et al.
Kalirin regulates cortical spine morphogenesis and disease-related behavioral phenotypes
PNAS, August 4, 2009; 106(31): 13058 - 13063.
[Abstract] [Full Text] [PDF]
A. W. Harrington, Q. M. Li, C. Tep, J. B. Park, Z. He, and S. O. Yoon
The Role of Kalirin9 in p75/Nogo Receptor-mediated RhoA Activation in Cerebellar Granule Neurons
J. Biol. Chem., September 5, 2008; 283(36): 24690 - 24697.
[Abstract] [Full Text] [PDF]
J. E. Waters, M. V. Astle, L. M. Ooms, D. Balamatsias, R. Gurung, and C. A. Mitchell
P-Rex1 - a multidomain protein that regulates neurite differentiation
J. Cell Sci., September 1, 2008; 121(17): 2892 - 2903.
[Abstract] [Full Text] [PDF]
X.-M. Ma, Y. Wang, F. Ferraro, R. E. Mains, and B. A. Eipper
Kalirin-7 Is an Essential Component of both Shaft and Spine Excitatory Synapses in Hippocampal Interneurons
J. Neurosci., January 16, 2008; 28(3): 711 - 724.
[Abstract] [Full Text] [PDF]
R. J. Rojas, M. E. Yohe, S. Gershburg, T. Kawano, T. Kozasa, and J. Sondek
G{alpha}q Directly Activates p63RhoGEF and Trio via a Conserved Extension of the Dbl Homology-associated Pleckstrin Homology Domain
J. Biol. Chem., October 5, 2007; 282(40): 29201 - 29210.
[Abstract] [Full Text] [PDF]
E. L. Tudor, M. S. Perkinton, A. Schmidt, S. Ackerley, J. Brownlees, N. J. O. Jacobsen, H. L. Byers, M. Ward, A. Hall, P. N. Leigh, et al.
ALS2/Alsin Regulates Rac-PAK Signaling and Neurite Outgrowth
J. Biol. Chem., October 14, 2005; 280(41): 34735 - 34740.
[Abstract] [Full Text] [PDF]
K. Chakrabarti, R. Lin, N. I. Schiller, Y. Wang, D. Koubi, Y.-X. Fan, B. B. Rudkin, G. R. Johnson, and M. R. Schiller
Critical Role for Kalirin in Nerve Growth Factor Signaling through TrkA
Mol. Cell. Biol., June 15, 2005; 25(12): 5106 - 5118.
[Abstract] [Full Text] [PDF]
C. A. Rabiner, R. E. Mains, and B. A. Eipper
Kalirin: A Dual Rho Guanine Nucleotide Exchange Factor That Is So Much More Than the Sum of Its Many Parts
Neuroscientist, April 1, 2005; 11(2): 148 - 160.
[Abstract] [PDF]
E.-E. Govek, S. E. Newey, and L. Van Aelst
The role of the Rho GTPases in neuronal development
Genes & Dev., January 1, 2005; 19(1): 1 - 49.
[Abstract] [Full Text] [PDF]
J. Peng, M. J. Kim, D. Cheng, D. M. Duong, S. P. Gygi, and M. Sheng
Semiquantitative Proteomic Analysis of Rat Forebrain Postsynaptic Density Fractions by Mass Spectrometry
J. Biol. Chem., May 14, 2004; 279(20): 21003 - 21011.
[Abstract] [Full Text] [PDF]
X.-M. Ma, J. Huang, Y. Wang, B. A. Eipper, and R. E. Mains
Kalirin, a Multifunctional Rho Guanine Nucleotide Exchange Factor, Is Necessary for Maintenance of Hippocampal Pyramidal Neuron Dendrites and Dendritic Spines
J. Neurosci., November 19, 2003; 23(33): 10593 - 10603.
[Abstract] [Full Text] [PDF]
E. Park, M. Na, J. Choi, S. Kim, J.-R. Lee, J. Yoon, D. Park, M. Sheng, and E. Kim
The Shank Family of Postsynaptic Density Proteins Interacts with and Promotes Synaptic Accumulation of the {beta}PIX Guanine Nucleotide Exchange Factor for Rac1 and Cdc42
J. Biol. Chem., May 23, 2003; 278(21): 19220 - 19229.
[Abstract] [Full Text] [PDF]
X. Guo, L. J. Stafford, B. Bryan, C. Xia, W. Ma, X. Wu, D. Liu, Z. Songyang, and M. Liu
A Rac/Cdc42-specific Exchange Factor, GEFT, Induces Cell Proliferation, Transformation, and Migration
J. Biol. Chem., April 4, 2003; 278(15): 13207 - 13215.
[Abstract] [Full Text] [PDF]
T. Kubo, T. Yamashita, A. Yamaguchi, H. Sumimoto, K. Hosokawa, and M. Tohyama
A Novel FERM Domain Including Guanine Nucleotide Exchange Factor Is Involved in Rac Signaling and Regulates Neurite Remodeling
J. Neurosci., October 1, 2002; 22(19): 8504 - 8513.
[Abstract] [Full Text] [PDF]
V. May, M. R. Schiller, B. A. Eipper, and R. E. Mains
Kalirin Dbl-Homology Guanine Nucleotide Exchange Factor 1 Domain Initiates New Axon Outgrowths via RhoG-Mediated Mechanisms
J. Neurosci., August 15, 2002; 22(16): 6980 - 6990.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|