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The Journal of Neuroscience, November 1, 2001, 21(21):8616-8623

Microcircuits for Night Vision in Mouse Retina

Yoshihiko Tsukamoto1, Katsuko Morigiwa2, Mika Ueda1, and Peter Sterling3

1 Department of Biology, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan, 2 Department of Physiology and Biosignalling, Graduate School of Medicine, Osaka University, Suita, Osaka 565-0871, Japan, and 3 Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104

Because the mouse retina has become an important model system, we have begun to identify its specific neuron types and their synaptic connections. Here, based on electron micrographs of serial sections, we report that the wild-type mouse retina expresses the standard rod pathways known in other mammals: (1) rod right-arrow cone (via gap junctions) to inject rod signals into the cone bipolar circuit; and (2) rod right-arrow rod bipolar right-arrow AII amacrine right-arrow cone bipolar right-arrow ganglion cell. The mouse also expresses another rod circuit: a bipolar cell with cone input also receives rod input at symmetrical contacts that express ionotropic glutamate receptors (Hack et al., 1999, 2001). We show that this rod-cone bipolar cell sends an axon to the outer (OFF) strata of the inner plexiform layer to form ribbon synapses with ganglion and amacrine cells. This rod-cone bipolar cell receives direct contacts from only 20% of all rod terminals. However, we also found that rod terminals form gap junctions with each other and thus establish partial syncytia that could pool rod signals for direct chemical transmission to the OFF bipolar cell. This third rod pathway probably explains the rod responses that persist in OFF ganglion cells after the well known rod pathways are blocked (Soucy et al., 1998).

Key words: mouse retina; microcircuitry; rod circuits; bipolar cells; gap junctions; electron microscopy

Copyright © 2001 Society for Neuroscience  0270-6474/01/21218616-08$05.00/0


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