 |
||||
|
||||
|
||||
|
||||
Previous Article | Next Article
The Journal of Neuroscience, November 15, 2001, 21(22):9018-9026
Lesions of the Basolateral Amygdala Disrupt Selective Aspects of Reinforcer Representation in Rats
Pam Blundell1, Geoffrey Hall1, and Simon Killcross2 1 Department of Psychology, University of York, Heslington, York, YO10 5DD United Kingdom, and 2 School of Psychology, Cardiff University, Cardiff CF10 3YG, United Kingdom
The amygdala is known to play a role in learning about motivationally significant events. We investigated this role further by examining the effects of excitotoxic lesions of the basolateral amygdala on the ability of rats to use instrumental outcomes to direct responding (the differential outcomes effect) and on the ability of Pavlovian cues to modulate instrumental performance based on shared outcomes (reinforcer-selective Pavlovian-to-instrumental transfer). We found that basolateral amygdala (BLA) lesions did not affect the ability of rats to learn a basic instrumental conditional discrimination, but did disrupt the ability of differential outcomes to facilitate acquisition. In Pavlovian-to-instrumental transfer, BLA lesions did not disrupt the basic enhancement of instrumental performance but did abolish the reinforcer specificity of that enhancement. These results suggest that the BLA is involved in the representation of the sensory aspects of motivationally significant events.
Key words: appetitive conditioning; basolateral amygdala; reward; reinforcement; Pavlovian; instrumental
Copyright © 2001 Society for Neuroscience 0270-6474/01/21229018-09$05.00/0
This article has been cited by other articles:
A. Lex and W. Hauber
Dopamine D1 and D2 receptors in the nucleus accumbens core and shell mediate Pavlovian-instrumental transfer
Learn. Mem., July 14, 2008; 15(7): 483 - 491.
[Abstract] [Full Text] [PDF]
S. Bray, A. Rangel, S. Shimojo, B. Balleine, and J. P O'Doherty
The Neural Mechanisms Underlying the Influence of Pavlovian Cues on Human Decision Making
J. Neurosci., May 28, 2008; 28(22): 5861 - 5866.
[Abstract] [Full Text] [PDF]
A. Ishikawa, F. Ambroggi, S. M. Nicola, and H. L. Fields
Dorsomedial Prefrontal Cortex Contribution to Behavioral and Nucleus Accumbens Neuronal Responses to Incentive Cues
J. Neurosci., May 7, 2008; 28(19): 5088 - 5098.
[Abstract] [Full Text] [PDF]
S. B. Ostlund and B. W. Balleine
Differential Involvement of the Basolateral Amygdala and Mediodorsal Thalamus in Instrumental Action Selection
J. Neurosci., April 23, 2008; 28(17): 4398 - 4405.
[Abstract] [Full Text] [PDF]
S. B. OSTLUND and B. W. BALLEINE
The Contribution of Orbitofrontal Cortex to Action Selection
Ann. N.Y. Acad. Sci., December 1, 2007; 1121(1): 174 - 192.
[Abstract] [Full Text] [PDF]
T. FURUYASHIKI and M. GALLAGHER
Neural Encoding in the Orbitofrontal Cortex Related to Goal-Directed Behavior
Ann. N.Y. Acad. Sci., December 1, 2007; 1121(1): 193 - 215.
[Abstract] [Full Text] [PDF]
A. R. DELAMATER
The Role of the Orbitofrontal Cortex in Sensory-Specific Encoding of Associations in Pavlovian and Instrumental Conditioning
Ann. N.Y. Acad. Sci., December 1, 2007; 1121(1): 152 - 173.
[Abstract] [Full Text] [PDF]
E. Knapska, K. Radwanska, T. Werka, and L. Kaczmarek
Functional Internal Complexity of Amygdala: Focus on Gene Activity Mapping After Behavioral Training and Drugs of Abuse
Physiol Rev, October 1, 2007; 87(4): 1113 - 1173.
[Abstract] [Full Text] [PDF]
S. B. Ostlund and B. W. Balleine
Orbitofrontal Cortex Mediates Outcome Encoding in Pavlovian But Not Instrumental Conditioning
J. Neurosci., May 2, 2007; 27(18): 4819 - 4825.
[Abstract] [Full Text] [PDF]
A. R. DELAMATER and S. OAKESHOTT
Learning about Multiple Attributes of Reward in Pavlovian Conditioning
Ann. N.Y. Acad. Sci., May 1, 2007; 1104(1): 1 - 20.
[Abstract] [Full Text] [PDF]
A. Izquierdo and E. A. Murray
Selective Bilateral Amygdala Lesions in Rhesus Monkeys Fail to Disrupt Object Reversal Learning
J. Neurosci., January 31, 2007; 27(5): 1054 - 1062.
[Abstract] [Full Text] [PDF]
D. M. Dwyer and S. Killcross
Lesions of the basolateral amygdala disrupt conditioning based on the retrieved representations of motivationally significant events.
J. Neurosci., August 9, 2006; 26(32): 8305 - 8309.
[Abstract] [Full Text] [PDF]
A. Murschall and W. Hauber
Inactivation of the ventral tegmental area abolished the general excitatory influence of Pavlovian cues on instrumental performance
Learn. Mem., March 1, 2006; 13(2): 123 - 126.
[Abstract] [Full Text] [PDF]
L. L. Wellman, K. Gale, and L. Malkova
GABAA-Mediated Inhibition of Basolateral Amygdala Blocks Reward Devaluation in Macaques
J. Neurosci., May 4, 2005; 25(18): 4577 - 4586.
[Abstract] [Full Text] [PDF]
M. A. McDannald, M. P. Saddoris, M. Gallagher, and P. C. Holland
Lesions of Orbitofrontal Cortex Impair Rats' Differential Outcome Expectancy Learning But Not Conditioned Stimulus-Potentiated Feeding
J. Neurosci., May 4, 2005; 25(18): 4626 - 4632.
[Abstract] [Full Text] [PDF]
A. W. Johnson, D. M. Bannerman, N. P. Rawlins, R. Sprengel, and M. A. Good
Impaired Outcome-Specific Devaluation of Instrumental Responding in Mice with a Targeted Deletion of the AMPA Receptor Glutamate Receptor 1 Subunit
J. Neurosci., March 2, 2005; 25(9): 2359 - 2365.
[Abstract] [Full Text] [PDF]
L. H. Corbit and B. W. Balleine
Double Dissociation of Basolateral and Central Amygdala Lesions on the General and Outcome-Specific Forms of Pavlovian-Instrumental Transfer
J. Neurosci., January 26, 2005; 25(4): 962 - 970.
[Abstract] [Full Text] [PDF]
A. Izquierdo and E. A. Murray
Combined Unilateral Lesions of the Amygdala and Orbital Prefrontal Cortex Impair Affective Processing in Rhesus Monkeys
J Neurophysiol, May 1, 2004; 91(5): 2023 - 2039.
[Abstract] [Full Text] [PDF]
P. Blundell, G. Hall, and S. Killcross
Preserved Sensitivity to Outcome Value after Lesions of the Basolateral Amygdala
J. Neurosci., August 20, 2003; 23(20): 7702 - 7709.
[Abstract] [Full Text] [PDF]
S. Killcross and E. Coutureau
Coordination of Actions and Habits in the Medial Prefrontal Cortex of Rats
Cereb Cortex, April 1, 2003; 13(4): 400 - 408.
[Abstract] [Full Text] [PDF]
G. Schoenbaum, B. Setlow, S. L. Nugent, M. P. Saddoris, and M. Gallagher
Lesions of Orbitofrontal Cortex and Basolateral Amygdala Complex Disrupt Acquisition of Odor-Guided Discriminations and Reversals
Learn. Mem., March 1, 2003; 10(2): 129 - 140.
[Abstract] [Full Text] [PDF]
B. W. Balleine, A. S. Killcross, and A. Dickinson
The Effect of Lesions of the Basolateral Amygdala on Instrumental Conditioning
J. Neurosci., January 15, 2003; 23(2): 666 - 675.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|