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The Journal of Neuroscience, November 15, 2001, 21(22):9018-9026
Lesions of the Basolateral Amygdala Disrupt Selective Aspects of Reinforcer Representation in Rats
Pam Blundell1, Geoffrey Hall1, and Simon Killcross2 1 Department of Psychology, University of York, Heslington, York, YO10 5DD United Kingdom, and 2 School of Psychology, Cardiff University, Cardiff CF10 3YG, United Kingdom
The amygdala is known to play a role in learning about motivationally significant events. We investigated this role further by examining the effects of excitotoxic lesions of the basolateral amygdala on the ability of rats to use instrumental outcomes to direct responding (the differential outcomes effect) and on the ability of Pavlovian cues to modulate instrumental performance based on shared outcomes (reinforcer-selective Pavlovian-to-instrumental transfer). We found that basolateral amygdala (BLA) lesions did not affect the ability of rats to learn a basic instrumental conditional discrimination, but did disrupt the ability of differential outcomes to facilitate acquisition. In Pavlovian-to-instrumental transfer, BLA lesions did not disrupt the basic enhancement of instrumental performance but did abolish the reinforcer specificity of that enhancement. These results suggest that the BLA is involved in the representation of the sensory aspects of motivationally significant events.
Key words: appetitive conditioning; basolateral amygdala; reward; reinforcement; Pavlovian; instrumental
Copyright © 2001 Society for Neuroscience 0270-6474/01/21229018-09$05.00/0
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