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Previous Article | Next Article
The Journal of Neuroscience, December 1, 2001, 21(23):9134-9141
Inhibition of Dopamine Release Via Presynaptic D2 Receptors: Time Course and Functional Characteristics In Vivo
Marianne Benoit-Marand1, Emiliana Borrelli2, and François Gonon1 1 Centre National de la Recherche Scientifique Unité Mixte de Recherche 5541, Université Victor Segalen, 33076 Bordeaux, France, and 2 Institut de Génétique et Biologie Moléculaire et Cellulaire, 67404 Illkirch, C. U. de Strasbourg, France
Most neurotransmitters inhibit their own release through autoreceptors. However, the physiological functions of these presynaptic inhibitions are still poorly understood, in part because their time course and functional characteristics have not been described in vivo. Dopamine inhibits its own release through D2 autoreceptors. Here, the part played by autoinhibition in the relationship between impulse flow and dopamine release was studied in vivo in real time. Dopamine release was evoked in the striatum of anesthetized mice by electrical stimulation of the medial forebrain bundle and was continuously monitored by amperometry using carbon fiber electrodes. Control experiments performed in mice lacking D2 receptors showed no autoinhibition of dopamine release. In wild-type mice, stimulation at 100 Hz with two to six pulses linearly inhibited further release, whereas single pulses were inefficient. Dopaminergic neurons exhibit two discharge patterns: single spikes forming a tonic activity below 4 Hz and bursts of two to six action potentials at 15 Hz. Stimulation mimicking one burst (four pulses at 15 Hz) promoted extracellular dopamine accumulation and thus inhibited further dopamine release. This autoinhibition was maximal between 150 and 300 msec after stimulation and disappeared within 600 msec. This delayed and prolonged time course is not reflected in extracellular DA availability and thus probably attributable to mechanisms downstream from autoreceptor stimulation. Thus, in physiological conditions, autoinhibition has two important roles. First, it contributes to the attenuation of extracellular dopamine during bursts. Second, autoinhibition elicited by one burst transiently attenuates further dopamine release elicited by tonic activity.
Key words: dopamine; release; presynaptic inhibition; D2 receptor; in vivo voltammetry; striatum; mouse
Copyright © 2001 Society for Neuroscience 0270-6474/01/21239134-08$05.00/0
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