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The Journal of Neuroscience, December 1, 2001, 21(23):9377-9386

Increased Synchronization of Cortical Oscillatory Activities between Human Supplementary Motor and Primary Sensorimotor Areas during Voluntary Movements

Shinji Ohara¹, Tatsuya Mima¹, Koichi Baba⁴, Akio Ikeda², Takeharu Kunieda³, Riki Matsumoto¹, Junichi Yamamoto¹, Masao Matsuhashi¹, Takashi Nagamine¹, Kenichi Hirasawa⁵, Tomokatsu Hori⁵, Tadahiro Mihara⁴, Nobuo Hashimoto³, Stephan Salenius⁶, and Hiroshi Shibasaki^{1, 2}

¹ Human Brain Research Center and Departments of ² Neurology and ³ Neurosurgery, Kyoto University Graduate School of Medicine, Shogoin, Sakyo, Kyoto, 606-8507, Japan, ⁴ The National Epilepsy Center, Shizuoka Higashi Hospital, Urushiyama, Shizuoka, 420-8688, Japan, ⁵ Department of Neurosurgery, Neurological Institute, Tokyo Women's Medical University, Kawada-Cho, Shinjuku-Ku, Tokyo 162-8666, Japan, and ⁶ Brain Research Unit, Low Temperature Laboratory, Helsinki University of Technology, FIN-02015HUT, Espoo, Finland

In human, both primary and nonprimary motor areas are involved in the control of voluntary movements. However, the dynamics of functional coupling among different motor areas has not been fully clarified yet. Because it has been proposed that the functional coupling among cortical areas might be achieved by the synchronization of oscillatory activity, we investigated the electrocorticographic coherence between the supplementary motor and primary sensorimotor areas (SMA and S1-M1) by means of event-related partial coherence analysis in 11 intractable epilepsy patients. We found premovement increase of coherence between the SMA proper and S1-M1 at the frequency of 0-33 Hz and between the pre-SMA and S1-M1 at 0-18 Hz. Coherence between the SMA proper and M1 started to increase 0.9 sec before the movement onset and peaked 0.3 sec after the movement. There was no systematic difference within the SMA (SMA proper vs pre-SMA) or within the S1-M1, in terms of the time course as well as the peak value of coherence. The phase spectra revealed near-zero phase difference in 57% (20 of 35) of region pairs analyzed, and the remaining pairs showed inconsistent results. This increase of synchronization between multiple motor areas in the preparation and execution of voluntary movements may reflect the multiregional functional interactions in human motor behavior.

Key words: event-related coherence; primary sensorimotor area; supplementary motor area; electrocorticography; voluntary movements; functional coupling

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Copyright © 2001 Society for Neuroscience  0270-6474/01/21239377-10$05.00/0

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