QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (27) Citing Articles via Google Scholar Google Scholar Articles by Manor, Y. Articles by Nadim, F. Search for Related Content PubMed PubMed Citation Articles by Manor, Y. Articles by Nadim, F.

 Previous Article  |  Next Article 

The Journal of Neuroscience, December 1, 2001, 21(23):9460-9470

Synaptic Depression Mediates Bistability in Neuronal Networks with Recurrent Inhibitory Connectivity

Yair Manor¹ and Farzan Nadim²

¹ Life Sciences Department and Zlotowski Center for Neurosciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel 84105, and ² Department of Mathematical Sciences, New Jersey Institute of Technology and Department of Biological Sciences, Rutgers University, Newark, New Jersey 07102

When depressing synapses are embedded in a circuit composed of a pacemaker neuron and a neuron with no autorhythmic properties, the network can show two modes of oscillation. In one mode the synapses are mostly depressed, and the oscillations are dominated by the properties of the oscillating neuron. In the other mode, the synapses recover from depression, and the oscillations are primarily controlled by the synapses. We demonstrate the two modes of oscillation in a hybrid circuit consisting of a biological pacemaker and a model neuron, reciprocally coupled via model depressing synapses. We show that across a wide range of parameter values this network shows robust bistability of the oscillation mode and that it is possible to switch the network from one mode to the other by injection of a brief current pulse in either neuron. The underlying mechanism for bistability may be present in many types of circuits with reciprocal connections and synaptic depression.

Key words: oscillation; reciprocal inhibition; motor systems; dynamic clamp; stomatogastric nervous system; crustacean

---

Copyright © 2001 Society for Neuroscience  0270-6474/01/21239460-11$05.00/0

This article has been cited by other articles:

				F. Frohlich, M. Bazhenov, I. Timofeev, M. Steriade, and T. J. Sejnowski Slow state transitions of sustained neural oscillations by activity-dependent modulation of intrinsic excitability. J. Neurosci., June 7, 2006; 26(23): 6153 - 6162. [Abstract] [Full Text] [PDF]

				V. Thirumalai, A. A. Prinz, C. D. Johnson, and E. Marder Red Pigment Concentrating Hormone Strongly Enhances the Strength of the Feedback to the Pyloric Rhythm Oscillator But Has Little Effect on Pyloric Rhythm Period J Neurophysiol, March 1, 2006; 95(3): 1762 - 1770. [Abstract] [Full Text] [PDF]

				P. Rabbah and F. Nadim Synaptic Dynamics Do Not Determine Proper Phase of Activity in a Central Pattern Generator J. Neurosci., December 7, 2005; 25(49): 11269 - 11278. [Abstract] [Full Text] [PDF]

				L. A. Grande and W. J. Spain Synaptic Depression as a Timing Device Physiology, June 1, 2005; 20(3): 201 - 210. [Abstract] [Full Text] [PDF]

				T. I. Netoff, M. I. Banks, A. D. Dorval, C. D. Acker, J. S. Haas, N. Kopell, and J. A. White Synchronization in Hybrid Neuronal Networks of the Hippocampal Formation J Neurophysiol, March 1, 2005; 93(3): 1197 - 1208. [Abstract] [Full Text] [PDF]

				M. Sorensen, S. DeWeerth, G. Cymbalyuk, and R. L. Calabrese Using a Hybrid Neural System to Reveal Regulation of Neuronal Network Activity by an Intrinsic Current J. Neurosci., June 9, 2004; 24(23): 5427 - 5438. [Abstract] [Full Text] [PDF]

				A. Mamiya and F. Nadim Dynamic Interaction of Oscillatory Neurons Coupled with Reciprocally Inhibitory Synapses Acts to Stabilize the Rhythm Period J. Neurosci., June 2, 2004; 24(22): 5140 - 5150. [Abstract] [Full Text] [PDF]

				P. H. M. Kullmann, D. W. Wheeler, J. Beacom, and J. P. Horn Implementation of a Fast 16-Bit Dynamic Clamp Using LabVIEW-RT J Neurophysiol, January 1, 2004; 91(1): 542 - 554. [Abstract] [Full Text]

				Y. Manor, A. Bose,, V. Booth, and F. Nadim, Contribution of Synaptic Depression to Phase Maintenance in a Model Rhythmic Network J Neurophysiol, November 1, 2003; 90(5): 3513 - 3528. [Abstract] [Full Text] [PDF]

				T. Nowotny, V. P. Zhigulin, A. I. Selverston, H. D. I. Abarbanel, and M. I. Rabinovich Enhancement of Synchronization in a Hybrid Neural Circuit by Spike-Timing Dependent Plasticity J. Neurosci., October 29, 2003; 23(30): 9776 - 9785. [Abstract] [Full Text] [PDF]

				G. A. Phares, E. G. Antzoulatos, D. A. Baxter, and J. H. Byrne Burst-Induced Synaptic Depression and Its Modulation Contribute to Information Transfer at Aplysia Sensorimotor Synapses: Empirical and Computational Analyses J. Neurosci., September 10, 2003; 23(23): 8392 - 8401. [Abstract] [Full Text] [PDF]

				A. Szucs, R. D. Pinto, M. I. Rabinovich, H. D. I. Abarbanel, and A. I. Selverston Synaptic Modulation of the Interspike Interval Signatures of Bursting Pyloric Neurons J Neurophysiol, March 1, 2003; 89(3): 1363 - 1377. [Abstract] [Full Text] [PDF]

				A. Rozzo, L. Ballerini, G. Abbate, and A. Nistri Experimental and Modeling Studies of Novel Bursts Induced by Blocking Na+ Pump and Synaptic Inhibition in the Rat Spinal Cord J Neurophysiol, August 1, 2002; 88(2): 676 - 691. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help