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The Journal of Neuroscience, December 1, 2001, 21(23):9471-9477
Differential Involvement of NMDA, AMPA/Kainate, and Dopamine
Receptors in the Nucleus Accumbens Core in the Acquisition and
Performance of Pavlovian Approach Behavior
Patricia
Di Ciano,
Rudolf N.
Cardinal,
Rosie A.
Cowell,
Simon J.
Little, and
Barry J.
Everitt
Department of Experimental Psychology, University of Cambridge,
Cambridge, CB2 3EB, United Kingdom
Stimuli paired with primary rewards can acquire emotional valence
and the ability to elicit automatic, Pavlovian approach responses that
have been shown to be mediated by the nucleus accumbens. The present
experiment investigated the effects of infusions of glutamatergic or
dopaminergic receptor antagonists into the core of the nucleus
accumbens on the acquisition and performance of Pavlovian discriminated
approach to an appetitive conditioned stimulus. Rats were trained on an
autoshaping task in which a conditioned stimulus (CS+; a lever)
was inserted into the operant chamber for 10 sec, after which a food
pellet was delivered. Presentation of another lever (CS ) was never
followed by food. Subjects developed a conditioned response of
approaching and contacting the CS+ selectively, although food delivery
was not in any way contingent on the animals' response. A triple
dissociation in the effects of AP-5, LY293558 [(3SR,
4aRS, 6RS,
8aRS)-6-[2-(iH-tetrazol-5-yl)ethyl]-1,2,3,4,4a,5,6,7,8,8a-decahydroiso-quinoline-3-carboxylic acid], and  -flupenthixol infused into the nucleus accumbens core on
the acquisition and performance of this conditioned response was
observed. The AMPA/kainate receptor antagonist LY293558 disrupted discriminated approach performance but not acquisition, as evidenced by
increased approaches to the CS. In contrast, the NMDA receptor antagonist AP-5 impaired only the acquisition, but not performance, of
autoshaping whereas the dopamine D1/D2 receptor antagonist -flupenthixol decreased approaches to the CS+ during both
acquisition and performance. The data are discussed with reference to
dissociable interactions of these receptor types with limbic cortical
and dopaminergic afferents to the nucleus accumbens core during the acquisition and expression of Pavlovian conditioned approach.
Key words:
glutamate; dopamine; conditioned stimulus; autoshaping; nucleus accumbens core; NMDA; AMPA
Copyright © 2001 Society for Neuroscience 0270-6474/01/21239471-07$05.00/0
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