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The Journal of Neuroscience, December 1, 2001, 21(23):9478-9486
Gap Junctions between Interneuron Dendrites Can Enhance Synchrony of Gamma Oscillations in Distributed Networks
Roger D. Traub1, 2, Nancy Kopell3, Andrea Bibbig1, 2, Eberhard H. Buhl4, Fiona E. N. LeBeau4, and Miles A. Whittington4 1 Department of Pharmacology, University of Birmingham School of Medicine, Edgbaston, Birmingham B15 2TT, United Kingdom, 2 Department of Physiology and Pharmacology, State University of New York Health Sciences Center, Brooklyn, New York 11203, 3 Department of Mathematics and Center for BioDynamics, Boston University, Boston, Massachusetts 02215, and 4 School of Biomedical Sciences, University of Leeds, Leeds LS2 9NQ, United Kingdom
Gamma-frequency (30-70 Hz) oscillations in populations of interneurons may be of functional relevance in the brain by virtue of their ability to induce synchronous firing in principal neurons. Such a role would require that neurons, 1 mm or more apart, be able to synchronize their activity, despite the presence of axonal conduction delays and of the limited axonal spread of many interneurons. We showed previously that interneuron doublet firing can help to synchronize gamma oscillations, provided that sufficiently many pyramidal neurons are active; we also suggested that gap junctions, between the axons of principal neurons, could contribute to the long-range synchrony of gamma oscillations induced in the hippocampus by carbachol in vitro. Here we consider interneuron network gamma: that is, gamma oscillations in pharmacologically isolated networks of tonically excited interneurons, with frequency gated by mutual GABAA receptor-mediated IPSPs. We provide simulation and electrophysiological evidence that interneuronal gap junctions (presumably dendritic) can enhance the synchrony of such gamma oscillations, in spatially extended interneuron networks. There appears to be a sharp threshold conductance, below which the interneuron dendritic gap junctions do not exert a synchronizing role.
Key words: 40 Hz; electrical coupling; synaptic inhibition; connexins; hippocampus; cortex
Copyright © 2001 Society for Neuroscience 0270-6474/01/21239478-09$05.00/0
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