 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, February 15, 2001, 21(4):1351-1360
Tuning and Topography in an Odor Map on the Rat Olfactory Bulb
Markus Meister1, 2 and Tobias Bonhoeffer2 1 Harvard University, Cambridge, Massachusetts 02138, and 2 Max Planck Institute of Neurobiology, D-82152 Munich-Martinsried, Germany
The sense of smell originates in a diverse array of receptor neurons, comprising up to 1000 different types. To understand how these parallel channels encode chemical stimuli, we recorded the responses of glomeruli in the olfactory bulbs of the anesthetized rat, by optical imaging of intrinsic signals. Odor stimulation produced two kinds of optical responses at the surface of the bulb: a broad diffuse component superposed by discrete small spots. Histology showed that the spots correspond to individual glomeruli, and that ~400 of them can be monitored in this way. Based on its wavelength-dependence, this optical signal appears to derive from changes in light scattering during neural activity. Pure odorants generally activated several glomeruli in a bilaterally symmetric pattern, whose extent varied greatly with concentration. A simple formalism for ligand binding accounts quantitatively for this concentration dependence and yields the effective affinity with which a glomerulus responds to an odorant. When tested with aliphatic molecules of increasing carbon chain length, many glomeruli were sharply tuned for one or two adjacent chain lengths. Glomeruli with similar tuning properties were located near each other, producing a systematic map of molecular chain length on the surface of the olfactory bulb. Given local inhibitory circuits within the olfactory bulb, this can account for the observed functional inhibition between related odors. We explore several parallels to the function and architecture of the visual system that help interpret the neural representation of odors.
Key words: olfaction; receptor; glomerulus; map; tuning; imaging
Copyright © 2001 Society for Neuroscience 0270-6474/01/2141351-10$05.00/0
This article has been cited by other articles:
P. C. Fernandez, F. F. Locatelli, N. Person-Rennell, G. Deleo, and B. H. Smith
Associative Conditioning Tunes Transient Dynamics of Early Olfactory Processing
J. Neurosci., August 19, 2009; 29(33): 10191 - 10202.
[Abstract] [Full Text] [PDF]
M. L. Fletcher, A. V. Masurkar, J. Xing, F. Imamura, W. Xiong, S. Nagayama, H. Mutoh, C. A. Greer, T. Knopfel, and W. R. Chen
Optical Imaging of Postsynaptic Odor Representation in the Glomerular Layer of the Mouse Olfactory Bulb
J Neurophysiol, August 1, 2009; 102(2): 817 - 830.
[Abstract] [Full Text] [PDF]
D. Chaudhury, O. Escanilla, and C. Linster
Bulbar Acetylcholine Enhances Neural and Perceptual Odor Discrimination
J. Neurosci., January 7, 2009; 29(1): 52 - 60.
[Abstract] [Full Text] [PDF]
A. S. Ghatpande
Is the Olfactory Bulb Computationally Similar to the Retina?
J Neurophysiol, January 1, 2009; 101(1): 1 - 4.
[Abstract] [Full Text] [PDF]
L. Luo, C. V. Gabel, H.-I. Ha, Y. Zhang, and A. D. T. Samuel
Olfactory Behavior of Swimming C. elegans Analyzed by Measuring Motile Responses to Temporal Variations of Odorants
J Neurophysiol, May 1, 2008; 99(5): 2617 - 2625.
[Abstract] [Full Text] [PDF]
M. Schmuker and G. Schneider
Processing and classification of chemical data inspired by insect olfaction
PNAS, December 18, 2007; 104(51): 20285 - 20289.
[Abstract] [Full Text] [PDF]
A. Koulakov, A. Gelperin, and D. Rinberg
Olfactory Coding With All-or-Nothing Glomeruli
J Neurophysiol, December 1, 2007; 98(6): 3134 - 3142.
[Abstract] [Full Text] [PDF]
A. A. Nikonov and J. Caprio
Highly Specific Olfactory Receptor Neurons for Types of Amino Acids in the Channel Catfish
J Neurophysiol, October 1, 2007; 98(4): 1909 - 1918.
[Abstract] [Full Text] [PDF]
J. C. Nawroth, C. A. Greer, W. R. Chen, S. B. Laughlin, and G. M. Shepherd
An Energy Budget for the Olfactory Glomerulus
J. Neurosci., September 5, 2007; 27(36): 9790 - 9800.
[Abstract] [Full Text] [PDF]
W. J. Tyler, G. C. Petzold, S. K. Pal, and V. N. Murthy
Experience-Dependent Modification of Primary Sensory Synapses in the Mammalian Olfactory Bulb
J. Neurosci., August 29, 2007; 27(35): 9427 - 9438.
[Abstract] [Full Text] [PDF]
E. Chaigneau, P. Tiret, J. Lecoq, M. Ducros, T. Knopfel, and S. Charpak
The Relationship between Blood Flow and Neuronal Activity in the Rodent Olfactory Bulb
J. Neurosci., June 13, 2007; 27(24): 6452 - 6460.
[Abstract] [Full Text] [PDF]
M. A. Carlsson, K. Y. Chong, W. Daniels, B. S. Hansson, and T. C. Pearce
Component Information Is Preserved in Glomerular Responses to Binary Odor Mixtures in the Moth Spodoptera littoralis
Chem Senses, June 1, 2007; 32(5): 433 - 443.
[Abstract] [Full Text] [PDF]
I. Manzini, C. Brase, T.-W. Chen, and D. Schild
Response profiles to amino acid odorants of olfactory glomeruli in larval Xenopus laevis
J. Physiol., June 1, 2007; 581(2): 567 - 579.
[Abstract] [Full Text] [PDF]
A. A. Nikonov and J. Caprio
Responses of Olfactory Forebrain Units to Amino Acids in the Channel Catfish
J Neurophysiol, March 1, 2007; 97(3): 2490 - 2498.
[Abstract] [Full Text] [PDF]
I. G. Davison and L. C. Katz
Sparse and Selective Odor Coding by Mitral/Tufted Neurons in the Main Olfactory Bulb
J. Neurosci., February 21, 2007; 27(8): 2091 - 2101.
[Abstract] [Full Text] [PDF]
T. A. Cleland, B. A. Johnson, M. Leon, and C. Linster
Relational representation in the olfactory system
PNAS, February 6, 2007; 104(6): 1953 - 1958.
[Abstract] [Full Text] [PDF]
C. A. Marks, K. Cheng, D. M. Cummings, and L. Belluscio
Activity-dependent plasticity in the olfactory intrabulbar map.
J. Neurosci., November 1, 2006; 26(44): 11257 - 11266.
[Abstract] [Full Text] [PDF]
K. Mori, Y. K. Takahashi, K. M. Igarashi, and M. Yamaguchi
Maps of Odorant Molecular Features in the Mammalian Olfactory Bulb
Physiol Rev, April 1, 2006; 86(2): 409 - 433.
[Abstract] [Full Text] [PDF]
D. Vucinic, L. B. Cohen, and E. K. Kosmidis
Interglomerular Center-Surround Inhibition Shapes Odorant-Evoked Input to the Mouse Olfactory Bulb In Vivo
J Neurophysiol, March 1, 2006; 95(3): 1881 - 1887.
[Abstract] [Full Text] [PDF]
N. E. Rawson
Olfactory Loss in Aging
Sci. Aging Knowl. Environ., February 8, 2006; 2006(5): pe6 - pe6.
[Abstract] [Full Text]
J. Mainland and N. Sobel
The Sniff Is Part of the Olfactory Percept
Chem Senses, February 1, 2006; 31(2): 181 - 196.
[Abstract] [Full Text] [PDF]
H. Spors, M. Wachowiak, L. B. Cohen, and R. W. Friedrich
Temporal Dynamics and Latency Patterns of Receptor Neuron Input to the Olfactory Bulb
J. Neurosci., January 25, 2006; 26(4): 1247 - 1259.
[Abstract] [Full Text] [PDF]
G. A Wright, M. G.A Thomson, and B. H Smith
Odour concentration affects odour identity in honeybees
Proc R Soc B, November 22, 2005; 272(1579): 2417 - 2422.
[Abstract] [Full Text] [PDF]
S. S. P. Magavi, B. D. Mitchell, O. Szentirmai, B. S. Carter, and J. D. Macklis
Adult-Born and Preexisting Olfactory Granule Neurons Undergo Distinct Experience-Dependent Modifications of their Olfactory Responses In Vivo
J. Neurosci., November 16, 2005; 25(46): 10729 - 10739.
[Abstract] [Full Text] [PDF]
T. A. Cleland and C. Linster
Computation in the Olfactory System
Chem Senses, November 1, 2005; 30(9): 801 - 813.
[Abstract] [Full Text] [PDF]
V. A. Kalatsky, D. B. Polley, M. M. Merzenich, C. E. Schreiner, and M. P. Stryker
Fine functional organization of auditory cortex revealed by Fourier optical imaging
PNAS, September 13, 2005; 102(37): 13325 - 13330.
[Abstract] [Full Text] [PDF]
J. Li, J. A. Mack, M. Souren, E. Yaksi, S.-i. Higashijima, M. Mione, J. R. Fetcho, and R. W. Friedrich
Early Development of Functional Spatial Maps in the Zebrafish Olfactory Bulb
J. Neurosci., June 15, 2005; 25(24): 5784 - 5795.
[Abstract] [Full Text] [PDF]
K. M. Igarashi and K. Mori
Spatial Representation of Hydrocarbon Odorants in the Ventrolateral Zones of the Rat Olfactory Bulb
J Neurophysiol, February 1, 2005; 93(2): 1007 - 1019.
[Abstract] [Full Text] [PDF]
P.-M. Lledo, G. Gheusi, and J.-D. Vincent
Information Processing in the Mammalian Olfactory System
Physiol Rev, January 1, 2005; 85(1): 281 - 317.
[Abstract] [Full Text] [PDF]
Y. K. Takahashi, S. Nagayama, and K. Mori
Detection and Masking of Spoiled Food Smells by Odor Maps in the Olfactory Bulb
J. Neurosci., October 6, 2004; 24(40): 8690 - 8694.
[Abstract] [Full Text] [PDF]
Y. K. Takahashi, M. Kurosaki, S. Hirono, and K. Mori
Topographic Representation of Odorant Molecular Features in the Rat Olfactory Bulb
J Neurophysiol, October 1, 2004; 92(4): 2413 - 2427.
[Abstract] [Full Text] [PDF]
I. Nelken, J. K. Bizley, F. R. Nodal, B. Ahmed, J. W. H. Schnupp, and A. J. King
Large-Scale Organization of Ferret Auditory Cortex Revealed Using Continuous Acquisition of Intrinsic Optical Signals
J Neurophysiol, October 1, 2004; 92(4): 2574 - 2588.
[Abstract] [Full Text] [PDF]
C. Collmann, M. A. Carlsson, B. S. Hansson, and A. Nighorn
Odorant-Evoked Nitric Oxide Signals in the Antennal Lobe of Manduca sexta
J. Neurosci., July 7, 2004; 24(27): 6070 - 6077.
[Abstract] [Full Text] [PDF]
A. A. Nikonov and J. Caprio
Odorant Specificity of Single Olfactory Bulb Neurons to Amino Acids in the Channel Catfish
J Neurophysiol, July 1, 2004; 92(1): 123 - 134.
[Abstract] [Full Text] [PDF]
S. Nagayama, Y. K. Takahashi, Y. Yoshihara, and K. Mori
Mitral and Tufted Cells Differ in the Decoding Manner of Odor Maps in the Rat Olfactory Bulb
J Neurophysiol, June 1, 2004; 91(6): 2532 - 2540.
[Abstract] [Full Text] [PDF]
R. W. Friedrich and G. Laurent
Dynamics of Olfactory Bulb Input and Output Activity During Odor Stimulation in Zebrafish
J Neurophysiol, June 1, 2004; 91(6): 2658 - 2669.
[Abstract] [Full Text] [PDF]
G. Coureaud, D. Langlois, G. Sicard, and B. Schaal
Newborn Rabbit Responsiveness to the Mammary Pheromone is Concentration-dependent
Chem Senses, May 1, 2004; 29(4): 341 - 350.
[Abstract] [Full Text] [PDF]
G. A. Wright and B. H. Smith
Different Thresholds for Detection and Discrimination of Odors in the Honey bee (Apis mellifera)
Chem Senses, February 1, 2004; 29(2): 127 - 135.
[Abstract] [Full Text] [PDF]
C. L. Iwema, H. Fang, D. B. Kurtz, S. L. Youngentob, and J. E. Schwob
Odorant Receptor Expression Patterns Are Restored in Lesion-Recovered Rat Olfactory Epithelium
J. Neurosci., January 14, 2004; 24(2): 356 - 369.
[Abstract] [Full Text] [PDF]
C. Martin, R. Gervais, E. Hugues, B. Messaoudi, and N. Ravel
Learning Modulation of Odor-Induced Oscillatory Responses in the Rat Olfactory Bulb: A Correlate of Odor Recognition?
J. Neurosci., January 14, 2004; 24(2): 389 - 397.
[Abstract] [Full Text] [PDF]
D. A. Wilson, M. L. Fletcher, and R. M. Sullivan
Acetylcholine and Olfactory Perceptual Learning
Learn. Mem., January 1, 2004; 11(1): 28 - 34.
[Abstract] [Full Text] [PDF]
M. Ditzen, J.-F. Evers, and C. G. Galizia
Odor Similarity Does Not Influence the Time Needed for Odor Processing
Chem Senses, November 1, 2003; 28(9): 781 - 789.
[Abstract] [Full Text] [PDF]
E. Chaigneau, M. Oheim, E. Audinat, and S. Charpak
Two-photon imaging of capillary blood flow in olfactory bulb glomeruli
PNAS, October 28, 2003; 100(22): 13081 - 13086.
[Abstract] [Full Text] [PDF]
F. Xu, N. Liu, I. Kida, D. L. Rothman, F. Hyder, and G. M. Shepherd
Odor maps of aldehydes and esters revealed by functional MRI in the glomerular layer of the mouse olfactory bulb
PNAS, September 16, 2003; 100(19): 11029 - 11034.
[Abstract] [Full Text] [PDF]
T. A. Christensen, H. Lei, and J. G. Hildebrand
Coordination of central odor representations through transient, non-oscillatory synchronization of glomerular output neurons
PNAS, September 16, 2003; 100(19): 11076 - 11081.
[Abstract] [Full Text] [PDF]
B. N. Johnson, J. D. Mainland, and N. Sobel
Rapid Olfactory Processing Implicates Subcortical Control of an Olfactomotor System
J Neurophysiol, August 1, 2003; 90(2): 1084 - 1094.
[Abstract] [Full Text] [PDF]
S. Bisulco and B. Slotnick
Olfactory Discrimination of Short Chain Fatty Acids in Rats with Large Bilateral Lesions of the Olfactory Bulbs
Chem Senses, June 1, 2003; 28(5): 361 - 370.
[Abstract] [Full Text] [PDF]
J. Cang and J. S. Isaacson
In Vivo Whole-Cell Recording of Odor-Evoked Synaptic Transmission in the Rat Olfactory Bulb
J. Neurosci., May 15, 2003; 23(10): 4108 - 4116.
[Abstract] [Full Text] [PDF]
M. A. Carlsson and B. S. Hansson
Dose-Response Characteristics of Glomerular Activity in the Moth Antennal Lobe
Chem Senses, May 1, 2003; 28(4): 269 - 278.
[Abstract] [Full Text] [PDF]
M. Wachowiak and L. B. Cohen
Correspondence Between Odorant-Evoked Patterns of Receptor Neuron Input and Intrinsic Optical Signals in the Mouse Olfactory Bulb
J Neurophysiol, March 1, 2003; 89(3): 1623 - 1639.
[Abstract] [Full Text] [PDF]
T. W Margrie and A. T Schaefer
Theta oscillation coupled spike latencies yield computational vigour in a mammalian sensory system
J. Physiol., January 15, 2003; 546(2): 363 - 374.
[Abstract] [Full Text] [PDF]
B. Goetze, H. Breer, and J. Strotmann
A Long-term Culture System for Olfactory Explants with Intrinsically Fluorescent Cell Populations
Chem Senses, November 1, 2002; 27(9): 817 - 824.
[Abstract] [Full Text] [PDF]
M. L. Schaefer, K. Yamazaki, K. Osada, D. Restrepo, and G. K. Beauchamp
Olfactory Fingerprints for Major Histocompatibility Complex-Determined Body Odors II: Relationship among Odor Maps, Genetics, Odor Composition, and Behavior
J. Neurosci., November 1, 2002; 22(21): 9513 - 9521.
[Abstract] [Full Text] [PDF]
N. N Urban and B. Sakmann
Reciprocal intraglomerular excitation and intra- and interglomerular lateral inhibition between mouse olfactory bulb mitral cells
J. Physiol., July 15, 2002; 542(2): 355 - 367.
[Abstract] [Full Text] [PDF]
Q. Yuan, C. W. Harley, J. H. McLean, and T. Knopfel
Optical Imaging of Odor Preference Memory in the Rat Olfactory Bulb
J Neurophysiol, June 1, 2002; 87(6): 3156 - 3159.
[Abstract] [Full Text] [PDF]
B. Slotnick and N. Bodyak
Odor Discrimination and Odor Quality Perception in Rats with Disruption of Connections between the Olfactory Epithelium and Olfactory Bulbs
J. Neurosci., May 15, 2002; 22(10): 4205 - 4216.
[Abstract] [Full Text] [PDF]
T. Bozza, P. Feinstein, C. Zheng, and P. Mombaerts
Odorant Receptor Expression Defines Functional Units in the Mouse Olfactory System
J. Neurosci., April 15, 2002; 22(8): 3033 - 3043.
[Abstract] [Full Text] [PDF]
M. A. Carlsson, C. G. Galizia, and B. S. Hansson
Spatial Representation of Odours in the Antennal Lobe of the Moth Spodoptera littoralis (Lepidoptera: Noctuidae)
Chem Senses, March 1, 2002; 27(3): 231 - 244.
[Abstract] [Full Text] [PDF]
H. U. Fried, S. H. Fuss, and S. I. Korsching
Selective imaging of presynaptic activity in the mouse olfactory bulb shows concentration and structure dependence of odor responses in identified glomeruli
PNAS, February 14, 2002; (2002) 52658399.
[Abstract] [Full Text] [PDF]
S. Sachse and C. G. Galizia
Role of Inhibition for Temporal and Spatial Odor Representation in Olfactory Output Neurons: A Calcium Imaging Study
J Neurophysiol, February 1, 2002; 87(2): 1106 - 1117.
[Abstract] [Full Text] [PDF]
C. Linster, B. A. Johnson, E. Yue, A. Morse, Z. Xu, E. E. Hingco, Y. Choi, M. Choi, A. Messiha, and M. Leon
Perceptual Correlates of Neural Representations Evoked by Odorant Enantiomers
J. Neurosci., December 15, 2001; 21(24): 9837 - 9843.
[Abstract] [Full Text] [PDF]
S. H. Fuss and S. I. Korsching
Odorant Feature Detection: Activity Mapping of Structure Response Relationships in the Zebrafish Olfactory Bulb
J. Neurosci., November 1, 2001; 21(21): 8396 - 8407.
[Abstract] [Full Text] [PDF]
H. U. Fried, S. H. Fuss, and S. I. Korsching
Selective imaging of presynaptic activity in the mouse olfactory bulb shows concentration and structure dependence of odor responses in identified glomeruli
PNAS, March 5, 2002; 99(5): 3222 - 3227.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|