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The Journal of Neuroscience, March 1, 2001, 21(5):1610-1618

Neural Network Partitioning by NO and cGMP

Nathaniel L. Scholz¹, Jan de Vente², James W. Truman¹, and Katherine Graubard¹

¹ University of Washington, Department of Zoology, Seattle, Washington 98195-1800, and ² University of Maastricht, Department of Psychiatry and Neuropsychology, 6200 MD Maastricht, The Netherlands

The stomatogastric ganglion (STG) of the crab Cancer productus contains ~30 neurons arrayed into two different networks (gastric mill and pyloric), each of which produces a distinct motor pattern in vitro. Here we show that the functional division of the STG into these two networks requires intact NO-cGMP signaling. Multiple nitric oxide synthase (NOS)-like proteins are expressed in the stomatogastric nervous system, and NO appears to be released as an orthograde transmitter from descending inputs to the STG. The receptor of NO, a soluble guanylate cyclase (sGC), is expressed in a subset of neurons in both motor networks. When NO diffusion or sGC activation are blocked within the ganglion, the two networks combine into a single conjoint circuit. The gastric mill motor rhythm breaks down, and several gastric neurons pattern switch and begin firing in pyloric time. The functional reorganization of the STG is both rapid and reversible, and the gastric mill motor rhythm is restored when the ganglion is returned to normal saline. Finally, pharmacological manipulations of the NO-cGMP pathway are ineffective when descending modulatory inputs to the STG are blocked. This suggests that the NO-cGMP pathway may interact with other biochemical cascades to partition rhythmic motor output from the ganglion.

Key words: NO; nitric oxide; cGMP; guanylate cyclase; stomatogastric; plasticity; crustacean; central pattern generator; cross talk

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Copyright © 2001 Society for Neuroscience  0270-6474/01/2151610-09$05.00/0

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