 |
||||
|
||||
|
||||
|
||||
Previous Article | Next Article
The Journal of Neuroscience, March 1, 2001, 21(5):1635-1644
Accumulation of Hippocampal Place Fields at the Goal Location in an Annular Watermaze Task
Stig A. Hollup1, Sturla Molden1, James G. Donnett2, May-Britt Moser1, and Edvard I. Moser1 1 Department of Psychology, Norwegian University of Science and Technology, 7491 Trondheim, Norway, and 2 Axona Ltd., St. Albans, Herts AL3 6EU, United Kingdom
To explore the plastic representation of information in spatially selective hippocampal pyramidal neurons, we made multiple single-unit recordings in rats trained to find a hidden platform at a constant location in a hippocampal-dependent annular watermaze task. Hippocampal pyramidal cells exhibited place-related firing in the watermaze. Place fields tended to accumulate near the platform, even in probe trials without immediate escape. The percentage of cells with peak activity around the hidden platform was more than twice the percentage firing in equally large areas elsewhere in the arena. The effect was independent of the actual position of the platform in the room frame. It was dissociable from ongoing motor behavior and was not related to linear or angular speed, swim direction, or variation in hippocampal theta activity. There was no accumulation of firing in any particular region in rats that were trained with a variable platform location. These training-dependent effects suggest that regions of particular behavioral significance may be over-represented in the hippocampal spatial map, even when these regions are completely unmarked.
Key words: hippocampus; place cells; learning; memory; recognition; spatial; plasticity; rat
Copyright © 2001 Society for Neuroscience 0270-6474/01/2151635-10$05.00/0
This article has been cited by other articles:
A. A. Fenton, H.-Y. Kao, S. A. Neymotin, A. Olypher, Y. Vayntrub, W. W. Lytton, and N. Ludvig
Unmasking the CA1 Ensemble Place Code by Exposures to Small and Large Environments: More Place Cells and Multiple, Irregularly Arranged, and Expanded Place Fields in the Larger Space
J. Neurosci., October 29, 2008; 28(44): 11250 - 11262.
[Abstract] [Full Text] [PDF]
I. R. Fiete, Y. Burak, and T. Brookings
What Grid Cells Convey about Rat Location
J. Neurosci., July 2, 2008; 28(27): 6858 - 6871.
[Abstract] [Full Text] [PDF]
J. J. Siegel, J. P. Neunuebel, and J. J. Knierim
Dominance of the Proximal Coordinate Frame in Determining the Locations of Hippocampal Place Cell Activity During Navigation
J Neurophysiol, January 1, 2008; 99(1): 60 - 76.
[Abstract] [Full Text] [PDF]
S. Leutgeb and J. K. Leutgeb
Pattern separation, pattern completion, and new neuronal codes within a continuous CA3 map
Learn. Mem., November 15, 2007; 14(11): 745 - 757.
[Abstract] [Full Text] [PDF]
J. A. Ainge, M. Tamosiunaite, F. Woergoetter, and P. A. Dudchenko
Hippocampal CA1 Place Cells Encode Intended Destination on a Maze with Multiple Choice Points
J. Neurosci., September 5, 2007; 27(36): 9769 - 9779.
[Abstract] [Full Text] [PDF]
R. E. Clark, N. J. Broadbent, and L. R. Squire
The Hippocampus and Spatial Memory: Findings with a Novel Modification of the Water Maze
J. Neurosci., June 20, 2007; 27(25): 6647 - 6654.
[Abstract] [Full Text] [PDF]
A. L. Griffin, H. Eichenbaum, and M. E. Hasselmo
Spatial Representations of Hippocampal CA1 Neurons Are Modulated by Behavioral Context in a Hippocampus-Dependent Memory Task
J. Neurosci., February 28, 2007; 27(9): 2416 - 2423.
[Abstract] [Full Text] [PDF]
V. Hok, P.-P. Lenck-Santini, S. Roux, E. Save, R. U. Muller, and B. Poucet
Goal-Related Activity in Hippocampal Place Cells
J. Neurosci., January 17, 2007; 27(3): 472 - 482.
[Abstract] [Full Text] [PDF]
V. P. Bingman and P. E. Sharp
Neuronal implementation of hippocampal-mediated spatial behavior: a comparative evolutionary perspective.
Behav Cogn Neurosci Rev, June 1, 2006; 5(2): 80 - 91.
[Abstract] [PDF]
D. M. Smith and S. J. Y. Mizumori
Learning-related development of context-specific neuronal responses to places and events: the hippocampal role in context processing.
J. Neurosci., March 22, 2006; 26(12): 3154 - 3163.
[Abstract] [Full Text] [PDF]
B. R. Fletcher, M. E. Calhoun, P. R. Rapp, and M. L. Shapiro
Fornix Lesions Decouple the Induction of Hippocampal Arc Transcription from Behavior But Not Plasticity
J. Neurosci., February 1, 2006; 26(5): 1507 - 1515.
[Abstract] [Full Text] [PDF]
S. Kubik and A. A. Fenton
Behavioral Evidence That Segregation and Representation Are Dissociable Hippocampal Functions
J. Neurosci., October 5, 2005; 25(40): 9205 - 9212.
[Abstract] [Full Text] [PDF]
S. Leutgeb, J. K. Leutgeb, C. A. Barnes, E. I. Moser, B. L. McNaughton, and M.-B. Moser
Independent Codes for Spatial and Episodic Memory in Hippocampal Neuronal Ensembles
Science, July 22, 2005; 309(5734): 619 - 623.
[Abstract] [Full Text] [PDF]
E. T. Rolls and J.-Z. Xiang
Reward-Spatial View Representations and Learning in the Primate Hippocampus
J. Neurosci., June 29, 2005; 25(26): 6167 - 6174.
[Abstract] [Full Text] [PDF]
V. Hok, E. Save, P. P. Lenck-Santini, and B. Poucet
Coding for spatial goals in the prelimbic/infralimbic area of the rat frontal cortex
PNAS, March 22, 2005; 102(12): 4602 - 4607.
[Abstract] [Full Text] [PDF]
B. Rivard, Y. Li, P.-P. Lenck-Santini, B. Poucet, and R. U. Muller
Representation of Objects in Space by Two Classes of Hippocampal Pyramidal Cells
J. Gen. Physiol., June 28, 2004; 124(1): 9 - 25.
[Abstract] [Full Text] [PDF]
F. P. Battaglia, G. R. Sutherland, and B. L. McNaughton
Local Sensory Cues and Place Cell Directionality: Additional Evidence of Prospective Coding in the Hippocampus
J. Neurosci., May 12, 2004; 24(19): 4541 - 4550.
[Abstract] [Full Text] [PDF]
M. M. Oh, A. G. Kuo, W. W. Wu, E. A. Sametsky, and J. F. Disterhoft
Watermaze Learning Enhances Excitability of CA1 Pyramidal Neurons
J Neurophysiol, October 1, 2003; 90(4): 2171 - 2179.
[Abstract] [Full Text] [PDF]
G. M. Muir and J. S. Taube
The neural correlates of navigation: do head direction and place cells guide spatial behavior?
Behav Cogn Neurosci Rev, December 1, 2002; 1(4): 297 - 317.
[Abstract] [PDF]
H.-A. Steffenach, R. S. Sloviter, E. I. Moser, and M.-B. Moser
Impaired retention of spatial memory after transection of longitudinally oriented axons of hippocampal CA3 pyramidal cells
PNAS, February 20, 2002; (2002) 42700999.
[Abstract] [Full Text] [PDF]
P. A. Gusev and D. L. Alkon
Intracellular Correlates of Spatial Memory Acquisition in Hippocampal Slices: Long-Term Disinhibition of CA1 Pyramidal Cells
J Neurophysiol, August 1, 2001; 86(2): 881 - 899.
[Abstract] [Full Text] [PDF]
H.-A. Steffenach, R. S. Sloviter, E. I. Moser, and M.-B. Moser
Impaired retention of spatial memory after transection of longitudinally oriented axons of hippocampal CA3 pyramidal cells
PNAS, March 5, 2002; 99(5): 3194 - 3198.
[Abstract] [Full Text] [PDF]
|
|
|
|
 |
|