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The Journal of Neuroscience, 2001, 21:RC134:1-6

RAPID COMMUNICATION
Independence of Firing Correlates of Anatomically Proximate Hippocampal Pyramidal Cells

A. David Redish^{1, 2}, Francesco P. Battaglia¹, Monica K. Chawla¹, Arne D. Ekstrom¹, Jason L. Gerrard¹, Peter Lipa¹, Ephron S. Rosenzweig¹, Paul F. Worley³, John F. Guzowski¹, Bruce L. McNaughton¹, and Carol A. Barnes¹

¹ Division of Neural Systems, Memory, and Aging, Arizona Research Laboratories, University of Arizona, Tucson, Arizona 85724, ² Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, and ³ Department of Neuroscience and Neurology, The Johns Hopkins University, Baltimore, Maryland 21205

In neocortex, neighboring neurons frequently exhibit correlated encoding properties. There is conflicting evidence whether a similar phenomenon occurs in hippocampus. To assess this quantitatively, a comparison was made of the spatial and temporal firing correlations within and between local groups of hippocampal cells, spaced 350-1400 µm apart. No evidence of clustering was found in a sample of >3000 neurons. Moreover, cells active in two environments were uniformly interspersed at a scale of <100 µm, as assessed by the activity-induced gene Arc. Independence of encoding characteristics implies uncorrelated inputs, which could enhance the capacity of the hippocampus to store arbitrary associations.

Key words: hippocampus; topography; place cell; spatial firing correlate; nonspatial firing correlate; tetrode; Arc; immediate early gene

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Copyright © Society for Neuroscience  0270-6474//$05.00/0

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