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The Journal of Neuroscience, March 15, 2001, 21(6):2113-2122
Symmetry, Stereotypy, and Topography of Odorant Representations
in Mouse Olfactory Bulbs
Leonardo
Belluscio and
Lawrence C.
Katz
Howard Hughes Medical Institute and Department of Neurobiology,
Duke University Medical Center, Durham, North Carolina 27710
The molecular basis of vertebrate odorant representations has been
derived extensively from mice. The functional correlates of these
molecular features were visualized using optical imaging of intrinsic
signals in mouse olfactory bulbs. Single odorants activated clusters of
glomeruli in consistent, restricted portions of the bulb. Patterns of
activated glomeruli were clearly bilaterally symmetric and consistent
in different individual mice, but the precise number, position, and
intensity of activated glomeruli in the two bulbs of the same
individual and between individuals varied considerably. Representations
of aliphatic aldehydes of different carbon chain length shifted
systematically along a rostral-caudal strip of the dorsal bulb,
indicating a functional topography of odorant representations. Binary
mixtures of individual aldehydes elicited patterns of glomerular
activation that were topographic combinations of the maps for each
individual odor. Thus the principles derived from the molecular
organization of a small subset of murine olfactory receptor neuron
projection patterns bilateral symmetry, local clustering, and local
variabilityare reliable guides to the initial functional
representation of odorant molecules.
Key words:
optical imaging; functional maps; glomeruli; odorant
mixtures; aldehydes; olfactory
Copyright © 2001 Society for Neuroscience 0270-6474/01/2162113-10$05.00/0
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