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The Journal of Neuroscience, March 15, 2001, 21(6):2186-2193
Cellular Imaging of zif268 Expression in the
Hippocampus and Amygdala during Contextual and Cued Fear Memory
Retrieval: Selective Activation of Hippocampal CA1 Neurons during the
Recall of Contextual Memories
Jeremy
Hall,
Kerrie L.
Thomas, and
Barry J.
Everitt
Department of Experimental Psychology, University of Cambridge,
Cambridge, CB2 3EB United Kingdom
The neuroanatomical and molecular basis of fear memory retrieval
was studied by analyzing the expression of the plasticity-associated immediate early gene zif268. Cellular
quantitative in situ hybridization revealed that
zif268 is expressed within specific regions of the hippocampus and amygdala during fear memory retrieval. Within the
hippocampus, increased expression of zif268 was observed
within CA1 neurons, but not dentate gyrus neurons, during the retrieval of contextual, but not cued, fear associations. In contrast,
zif268 expression was increased within neurons of the
amygdala (lateral, basal, and central nuclei) during the retrieval of
both contextual and cued fear memories. These results demonstrate
activation of hippocampal CA1 neurons in contextual fear memory
retrieval that was not merely a correlate of the behavioral expression
of fear itself, because it was limited to the retrieval of contextual, and not cued, fear memories. Further studies revealed that the selective increase in hippocampal CA1 zif268 expression
seen after contextual fear memory retrieval was limited to the
retrieval of recent (24 hr) but not older (28 d) memories. These
experiments represent the first demonstration that
zif268 expression in specific neuronal populations is
associated with memory retrieval and suggest that this gene may
contribute to plasticity and reconsolidation accompanying the retrieval process.
Key words:
zif268; gene expression; fear conditioning; memory retrieval; hippocampus; amygdala
Copyright © 2001 Society for Neuroscience 0270-6474/01/2162186-08$05.00/0
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