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The Journal of Neuroscience, April 15, 2001, 21(8):2678-2686
Transport and Localization of the DEG/ENaC Ion Channel BNaC1
to Peripheral Mechanosensory Terminals of Dorsal Root Ganglia Neurons
Jaime García-Añoveros1, Tarek A. Samad2, Ljiljana uvela-Jelaska1,
Clifford J. Woolf2, and David P. Corey1 1 Howard Hughes Medical Institute and Department of Neurobiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, and 2 Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129
Mammalian brain sodium channel (BNaC, also known as BNC/ASIC) proteins form acid-sensitive and amiloride-blockable sodium channels that are related to putative mechanosensory channels. Certain BNaC isoforms are expressed exclusively in dorsal root ganglia (DRG) and have been proposed to form the ion channels mediating tissue acidosis-induced pain. With antibody labeling, we find that the BNaC1
isoform is expressed by most large DRG neurons (low-threshold mechanosensors not involved in acid-induced nociception) and few small nociceptor neurons (which include high-threshold mechanoreceptors). BNaC1
Key words: DEG/ENaC channels; mechanosensory; mechanotransduction; touch; nociception; dorsal root ganglion; unidirectional transport; degenerin
Copyright © 2001 Society for Neuroscience 0270-6474/01/2182678-09$05.00/0
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