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Previous Article | Next Article
The Journal of Neuroscience, April 15, 2001, 21(8):2793-2798
Predictability Modulates Human Brain Response to Reward
Gregory S. Berns1, Samuel M. McClure2, Giuseppe Pagnoni1, and P. Read Montague2 1 Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, and 2 Center for Theoretical Neuroscience, Division of Neuroscience, Baylor College of Medicine, Houston, Texas 77030
Certain classes of stimuli, such as food and drugs, are highly effective in activating reward regions. We show in humans that activity in these regions can be modulated by the predictability of the sequenced delivery of two mildly pleasurable stimuli, orally delivered fruit juice and water. Using functional magnetic resonance imaging, the activity for rewarding stimuli in both the nucleus accumbens and medial orbitofrontal cortex was greatest when the stimuli were unpredictable. Moreover, the subjects' stated preference for either juice or water was not directly correlated with activity in reward regions but instead was correlated with activity in sensorimotor cortex. For pleasurable stimuli, these findings suggest that predictability modulates the response of human reward regions, and subjective preference can be dissociated from this response.
Key words: reward; dopamine; fMRI; reinforcement; neural network; nucleus accumbens; striatum
Copyright © 2001 Society for Neuroscience 0270-6474/01/2182793-06$05.00/0
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