 |
|||||
|
|||||
|
|||||
|
|||||
|
|||||
Previous Article | Next Article
The Journal of Neuroscience, May 1, 2001, 21(9):3261-3270
Fear and Feeding in the Nucleus Accumbens Shell: Rostrocaudal Segregation of GABA-Elicited Defensive Behavior Versus Eating Behavior
Sheila M. Reynolds and Kent C. Berridge Department of Psychology, University of Michigan, Ann Arbor, Michigan 48109
This study examined localization of positive versus negative motivational functions mediated by GABA circuits within the accumbens shell. Microinjections of a GABAA agonist (0, 25, 75, and 225 ng/0.5 µl muscimol) in rostral shell sites elicited appetitive increases in eating behavior. In contrast, microinjections in caudal shell sites elicited defensive burying or paw-treading behavior. Rats whose microinjections landed bilaterally outside of the accumbens shell did not display either behavior. Defensive treading elicited by caudal shell muscimol microinjection appeared to be a negative motivated response to threat (similar in parameters and orientation to normal defensive burying of a threatening electrified shock prod). The nucleus accumbens shell thus appears functionally heterogeneous in coding motivational valence. The demonstration that muscimol elicits positive eating behavior from rostral shell versus negative defensive behavior from caudal shell suggests in particular that GABAergic substrates of positive and negative types of motivated behavior in the nucleus accumbens shell are segregated along a rostrocaudal gradient.
Key words: accumbens shell; GABA; food intake; reward; appetite; motivation; glutamate; dopamine; fear; defense; aggression; mesolimbic; microinjection
Copyright © 2001 Society for Neuroscience 0270-6474/01/2193261-10$05.00/0
This article has been cited by other articles:
Y. Worbe, N. Baup, D. Grabli, M. Chaigneau, S. Mounayar, K. McCairn, J. Feger, and L. Tremblay
Behavioral and Movement Disorders Induced by Local Inhibitory Dysfunction in Primate Striatum
Cereb Cortex, August 1, 2009; 19(8): 1844 - 1856.
[Abstract] [Full Text] [PDF]
S. V. Mahler and K. C. Berridge
Which Cue to "Want?" Central Amygdala Opioid Activation Enhances and Focuses Incentive Salience on a Prepotent Reward Cue
J. Neurosci., May 20, 2009; 29(20): 6500 - 6513.
[Abstract] [Full Text] [PDF]
J. Peters, P. W. Kalivas, and G. J. Quirk
Extinction circuits for fear and addiction overlap in prefrontal cortex
Learn. Mem., April 20, 2009; 16(5): 279 - 288.
[Abstract] [Full Text] [PDF]
A. Faure, S. M. Reynolds, J. M. Richard, and K. C. Berridge
Mesolimbic Dopamine in Desire and Dread: Enabling Motivation to Be Generated by Localized Glutamate Disruptions in Nucleus Accumbens
J. Neurosci., July 9, 2008; 28(28): 7184 - 7192.
[Abstract] [Full Text] [PDF]
C. A. Hutcherson, P. R. Goldin, W. Ramel, K. McRae, and J. J. Gross
Attention and emotion influence the relationship between extraversion and neural response
Soc Cogn Affect Neurosci, March 1, 2008; 3(1): 71 - 79.
[Abstract] [Full Text] [PDF]
A. Jean, G. Conductier, C. Manrique, C. Bouras, P. Berta, R. Hen, Y. Charnay, J. Bockaert, and V. Compan
Anorexia induced by activation of serotonin 5-HT4 receptors is mediated by increases in CART in the nucleus accumbens
PNAS, October 9, 2007; 104(41): 16335 - 16340.
[Abstract] [Full Text] [PDF]
H. Sano and M. Yokoi
Striatal Medium Spiny Neurons Terminate in a Distinct Region in the Lateral Hypothalamic Area and Do Not Directly Innervate Orexin/Hypocretin- or Melanin-Concentrating Hormone-Containing Neurons
J. Neurosci., June 27, 2007; 27(26): 6948 - 6955.
[Abstract] [Full Text] [PDF]
B. Seymour, N. Daw, P. Dayan, T. Singer, and R. Dolan
Differential Encoding of Losses and Gains in the Human Striatum
J. Neurosci., May 2, 2007; 27(18): 4826 - 4831.
[Abstract] [Full Text] [PDF]
K. S. Smith and K. C. Berridge
The Ventral Pallidum and Hedonic Reward: Neurochemical Maps of Sucrose "Liking" and Food Intake
J. Neurosci., September 21, 2005; 25(38): 8637 - 8649.
[Abstract] [Full Text] [PDF]
A. J. Calder, J. Keane, A. D. Lawrence, and F. Manes
Impaired recognition of anger following damage to the ventral striatum
Brain, September 1, 2004; 127(9): 1958 - 1969.
[Abstract] [Full Text] [PDF]
S. M. Nicola, I. A. Yun, K. T. Wakabayashi, and H. L. Fields
Firing of Nucleus Accumbens Neurons During the Consummatory Phase of a Discriminative Stimulus Task Depends on Previous Reward Predictive Cues
J Neurophysiol, April 1, 2004; 91(4): 1866 - 1882.
[Abstract] [Full Text] [PDF]
R.L. Albin, R.A. Koeppe, N.I. Bohnen, T.E. Nichols, P. Meyer, K. Wernette, S. Minoshima, M.R. Kilbourn, and K.A. Frey
Increased ventral striatal monoaminergic innervation in Tourette syndrome
Neurology, August 12, 2003; 61(3): 310 - 315.
[Abstract] [Full Text] [PDF]
H. Zheng, M. Corkern, I. Stoyanova, L. M. Patterson, R. Tian, and H.-R. Berthoud
Peptides that Regulate Food Intake: Appetite-inducing accumbens manipulation activates hypothalamic orexin neurons and inhibits POMC neurons
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2003; 284(6): R1436 - R1444.
[Abstract] [Full Text] [PDF]
J. L. Fudge and S. N. Haber
Defining the Caudal Ventral Striatum in Primates: Cellular and Histochemical Features
J. Neurosci., December 1, 2002; 22(23): 10078 - 10082.
[Abstract] [Full Text] [PDF]
S. M. Reynolds and K. C. Berridge
Positive and Negative Motivation in Nucleus Accumbens Shell: Bivalent Rostrocaudal Gradients for GABA-Elicited Eating, Taste "Liking"/"Disliking" Reactions, Place Preference/Avoidance, and Fear
J. Neurosci., August 15, 2002; 22(16): 7308 - 7320.
[Abstract] [Full Text] [PDF]
A. E. Kelley and K. C. Berridge
The Neuroscience of Natural Rewards: Relevance to Addictive Drugs
J. Neurosci., May 1, 2002; 22(9): 3306 - 3311.
[Full Text] [PDF]
|
|
|
|
 |
|