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The Journal of Neuroscience, 2001, 21:RC195:1-6

RAPID COMMUNICATION
Prenatal Choline Supplementation Protects against Postnatal Neurotoxicity

Shirley X. Guo-Ross^{1, 3}, Suzanne Clark^{1, 2}, Daniel A. C. Montoya^{1, 3}, Katherine H. Jones^{1, 2}, Jennifer Obernier⁶, Ashok K. Shetty^{1, 4}, Aaron M. White^{1, 3}, Jan Krzysztof Blusztajn⁷, Wilkie A. Wilson^{1, 2}, and H. Scott Swartzwelder^{1, 3, 5}

¹ Neurobiology Research Laboratory, Veterans Affairs Medical Center, Durham, North Carolina 27705, Departments of ² Pharmacology, ³ Psychiatry, and ⁴ Surgery, Duke University Medical Center, Durham, North Carolina 27710, ⁵ Department of Psychology, Duke University, Durham, North Carolina 27710, ⁶ Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27514, and ⁷ Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts 02118

Choline, a dietary compound present in many foods, has recently been classified as an essential nutrient for humans. There is evidence from animal models that the availability of choline during the prenatal period influences neural and cognitive development. Here we report that choline supplementation during a 6 d gestational period protects against neurodegeneration in the posterior cingulate and retrosplenial cortices of female adolescent rats produced by peripheral administration of the NMDA receptor antagonist dizocilpine (MK-801). These data show that availability of a single nutrient, choline, during a brief period of prenatal development diminishes vulnerability to neurotoxicity in adolescent offspring.

Key words: choline; neurotoxicity; cingulate; NMDA; MK-801; supplementation

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