QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (14) Citing Articles via Google Scholar Google Scholar Articles by Reid, C. B. Articles by Walsh, C. A. Search for Related Content PubMed PubMed Citation Articles by Reid, C. B. Articles by Walsh, C. A.

 Previous Article  |  Next Article 

The Journal of Neuroscience, May 15, 2002, 22(10):4002-4014

Evidence of Common Progenitors and Patterns of Dispersion in Rat Striatum and Cerebral Cortex

Christopher B. Reid^{1, 2} and Christopher A. Walsh^{3, 4, 5}

¹ Department of Pharmacology and ² Neuroscience Program, F. Edward Hebert School of Medicine, Uniformed Services University, Bethesda, Maryland 20814, ³ Division of Neurogenetics, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, Massachusetts 02115, and ⁴ Program in Neuroscience and ⁵ Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, Massachusetts 02115

To correlate clonal patterns in the rat striatum with adult neuronal phenotypes, we labeled striatal progenitors between embryonic day 14 (E14) and E19 with a retroviral library encoding alkaline phosphatase. In the adult striatum, the majority of E14-labeled neurons (87%) were members of discrete horizontal or radial cell clusters. Radial clusters accounted for only 23% of cell clusters but >34% of labeled cells. Striatal clones also demonstrated an unexpected widespread pattern of clonal dispersion. The majority of striatal clones were widely dispersed within the striatum, and 80% of clones were part of even larger clones that included cortical interneurons. Finally, we observed that PCR-positive cortical interneurons were members of clones containing both interneurons and pyramids (44%), exclusively interneuron clones (24%), or combined striatal-cortical clones (16%), consistent with the view that cortical interneurons have multiple origins in differentially behaving progenitor cells. Our data are also consistent with the notion that similar mechanisms underpin striatal and cortical development.

Key words: cortex; striatum; radial migration; tangential migration; clonal analysis; pyramidal neuron; nonpyramidal neuron; interneurons; radial glia

---

Copyright © 2002 Society for Neuroscience  0270-6474/02/22104002-13$05.00/0

This article has been cited by other articles:

				M. R. Costa, O. Bucholz, T. Schroeder, and M. Gotz Late Origin of Glia-Restricted Progenitors in the Developing Mouse Cerebral Cortex Cereb Cortex, July 1, 2009; 19(suppl_1): i135 - i143. [Abstract] [Full Text] [PDF]

				Q. Xu, C. P. Wonders, and S. A. Anderson Sonic hedgehog maintains the identity of cortical interneuron progenitors in the ventral telencephalon Development, November 15, 2005; 132(22): 4987 - 4998. [Abstract] [Full Text] [PDF]

				M. Gotz Glial Cells Generate Neurons--Master Control within CNS Regions: Developmental Perspectives on Neural Stem Cells Neuroscientist, October 1, 2003; 9(5): 379 - 397. [Abstract] [PDF]

				T. C. Badea, Y. Wang, and J. Nathans A Noninvasive Genetic/Pharmacologic Strategy for Visualizing Cell Morphology and Clonal Relationships in the Mouse J. Neurosci., March 15, 2003; 23(6): 2314 - 2322. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help