QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (64) Citing Articles via Google Scholar Google Scholar Articles by Poncer, J. C. Articles by Malinow, R. Search for Related Content PubMed PubMed Citation Articles by Poncer, J. C. Articles by Malinow, R.

 Previous Article  |  Next Article 

The Journal of Neuroscience, June 1, 2002, 22(11):4406-4411

Multiple Mechanisms for the Potentiation of AMPA Receptor-Mediated Transmission by -Ca²⁺/Calmodulin-Dependent Protein Kinase II

Jean Christophe Poncer^{1, 2}, José A. Esteban¹, and Roberto Malinow¹

¹ Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, and ² Institut National de la Santé et de la Recherche Médicale, Cortex and Epilepsie, 75006 Paris, France

Some forms of activity-dependent synaptic potentiation require the activation of postsynaptic Ca²⁺/calmodulin-dependent protein kinase II (CaMKII). Activation of CaMKII has been shown to phosphorylate the glutamate receptor 1 subunit of the AMPA receptor (AMPAR), thereby affecting some of the properties of the receptor. Here, a recombinant, constitutively active form of CaMKII tagged with the fluorescent marker green fluorescent protein (GFP) [CaMKII_1-290-enhanced GFP (EGFP)] was expressed in CA1 pyramidal neurons from hippocampal slices. The changes in glutamatergic transmission onto these cells were analyzed. AMPA but not NMDA receptor-mediated EPSCs were specifically potentiated in infected compared with nearby noninfected neurons. This potentiation was associated with a reduction in the proportion of synapses devoid of AMPARs. In addition, expression of CaMKII_1-290-EGFP increased the quantal size of AMPAR-mediated responses. This effect reflected, at least in part, an increased unitary conductance of the channels underlying the EPSCs. These results reveal that several key features of long-term potentiation of hippocampal glutamatergic synapses are reproduced by the sole activity of CaMKII.

Key words: synaptic plasticity; CaMKII; viral transfection; silent synapses; AMPA receptors; LTP

---

Copyright © 2002 Society for Neuroscience  0270-6474/02/22114406-06$05.00/0

This article has been cited by other articles:

				Z. Gu, W. Liu, and Z. Yan {beta}-Amyloid Impairs AMPA Receptor Trafficking and Function by Reducing Ca2+/Calmodulin-dependent Protein Kinase II Synaptic Distribution J. Biol. Chem., April 17, 2009; 284(16): 10639 - 10649. [Abstract] [Full Text] [PDF]

				A. R. Ferguson, K. A. Bolding, J. R. Huie, M. A. Hook, D. R. Santillano, R. C. Miranda, and J. W. Grau Group I Metabotropic Glutamate Receptors Control Metaplasticity of Spinal Cord Learning through a Protein Kinase C-Dependent Mechanism J. Neurosci., November 12, 2008; 28(46): 11939 - 11949. [Abstract] [Full Text] [PDF]

				S. J. Tavalin AKAP79 Selectively Enhances Protein Kinase C Regulation of GluR1 at a Ca2+-Calmodulin-dependent Protein Kinase II/Protein Kinase C Site J. Biol. Chem., April 25, 2008; 283(17): 11445 - 11452. [Abstract] [Full Text] [PDF]

				G.-D. Chen, M.-L. Peng, P.-Y. Wang, S.-D. Lee, H.-M. Chang, S.-F. Pan, M.-J. Chen, K.-C. Tung, C.-Y. Lai, and T.-B. Lin Calcium/calmodulin-dependent kinase II mediates NO-elicited PKG activation to participate in spinal reflex potentiation in anesthetized rats Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2008; 294(2): R487 - R493. [Abstract] [Full Text] [PDF]

				N. R. Wilson, M. T. Ty, D. E. Ingber, M. Sur, and G. Liu Synaptic Reorganization in Scaled Networks of Controlled Size J. Neurosci., December 12, 2007; 27(50): 13581 - 13589. [Abstract] [Full Text] [PDF]

				M. Sanhueza, C. C. McIntyre, and J. E. Lisman Reversal of Synaptic Memory by Ca2+/Calmodulin-Dependent Protein Kinase II Inhibitor J. Neurosci., May 9, 2007; 27(19): 5190 - 5199. [Abstract] [Full Text] [PDF]

				M. V. Caldeira, C. V. Melo, D. B. Pereira, R. Carvalho, S. S. Correia, D. S. Backos, A. L. Carvalho, J. A. Esteban, and C. B. Duarte Brain-derived Neurotrophic Factor Regulates the Expression and Synaptic Delivery of{alpha}-Amino-3-hydroxy-5-methyl-4-isoxazole Propionic Acid Receptor Subunits in Hippocampal Neurons J. Biol. Chem., April 27, 2007; 282(17): 12619 - 12628. [Abstract] [Full Text] [PDF]

				D. D. Kline, A. Ramirez-Navarro, and D. L. Kunze Adaptive Depression in Synaptic Transmission in the Nucleus of the Solitary Tract after In Vivo Chronic Intermittent Hypoxia: Evidence for Homeostatic Plasticity J. Neurosci., April 25, 2007; 27(17): 4663 - 4673. [Abstract] [Full Text] [PDF]

				B. A. Earnshaw and P. C. Bressloff Biophysical Model of AMPA Receptor Trafficking and Its Regulation during Long-Term Potentiation/Long-Term Depression. J. Neurosci., November 22, 2006; 26(47): 12362 - 12373. [Abstract] [Full Text] [PDF]

				W. R. Holmes and L. M. Grover Quantifying the Magnitude of Changes in Synaptic Level Parameters With Long-Term Potentiation J Neurophysiol, September 1, 2006; 96(3): 1478 - 1491. [Abstract] [Full Text] [PDF]

				J. Boehm, I. Ehrlich, H. Hsieh, and R. Malinow Two mutations preventing PDZ-protein interactions of GluR1 have opposite effects on synaptic plasticity Learn. Mem., September 1, 2006; 13(5): 562 - 565. [Abstract] [Full Text] [PDF]

				C. Cabezas and W. Buno Distinct Transmitter Release Properties Determine Differences in Short-Term Plasticity at Functional and Silent Synapses J Neurophysiol, May 1, 2006; 95(5): 3024 - 3034. [Abstract] [Full Text] [PDF]

				C. M. McDermott, M. N. Hardy, N. G. Bazan, and J. C. Magee Sleep deprivation-induced alterations in excitatory synaptic transmission in the CA1 region of the rat hippocampus J. Physiol., February 1, 2006; 570(3): 553 - 565. [Abstract] [Full Text] [PDF]

				C.-S. Chan, E. J. Weeber, L. Zong, E. Fuchs, J. D. Sweatt, and R. L. Davis {beta}1-Integrins Are Required for Hippocampal AMPA Receptor-Dependent Synaptic Transmission, Synaptic Plasticity, and Working Memory J. Neurosci., January 4, 2006; 26(1): 223 - 232. [Abstract] [Full Text] [PDF]

				C. I. Nam and L. Chen Postsynaptic assembly induced by neurexin-neuroligin interaction and neurotransmitter PNAS, April 26, 2005; 102(17): 6137 - 6142. [Abstract] [Full Text] [PDF]

				J. M. Schmitt, E. S. Guire, T. Saneyoshi, and T. R. Soderling Calmodulin-Dependent Kinase Kinase/Calmodulin Kinase I Activity Gates Extracellular-Regulated Kinase-Dependent Long-Term Potentiation J. Neurosci., February 2, 2005; 25(5): 1281 - 1290. [Abstract] [Full Text] [PDF]

				N. Z. Gerges, D. S. Backos, and J. A. Esteban Local Control of AMPA Receptor Trafficking at the Postsynaptic Terminal by a Small GTPase of the Rab Family J. Biol. Chem., October 15, 2004; 279(42): 43870 - 43878. [Abstract] [Full Text] [PDF]

				B. K. Andrasfalvy and J. C. Magee Changes in AMPA receptor currents following LTP induction on rat CA1 pyramidal neurones J. Physiol., September 1, 2004; 559(2): 543 - 554. [Abstract] [Full Text] [PDF]

				M. J. Palmer, J. T. R. Isaac, and G. L. Collingridge Multiple, Developmentally Regulated Expression Mechanisms of Long-Term Potentiation at CA1 Synapses J. Neurosci., May 26, 2004; 24(21): 4903 - 4911. [Abstract] [Full Text] [PDF]

				N. Z. Gerges, I. C. Tran, D. S. Backos, J. M. Harrell, M. Chinkers, W. B. Pratt, and J. A. Esteban Independent Functions of hsp90 in Neurotransmitter Release and in the Continuous Synaptic Cycling of AMPA Receptors J. Neurosci., May 19, 2004; 24(20): 4758 - 4766. [Abstract] [Full Text] [PDF]

				A. W. Varga, L.-L. Yuan, A. E. Anderson, L. A. Schrader, G.-Y. Wu, J. R. Gatchel, D. Johnston, and J. D. Sweatt Calcium-Calmodulin-Dependent Kinase II Modulates Kv4.2 Channel Expression and Upregulates Neuronal A-Type Potassium Currents J. Neurosci., April 7, 2004; 24(14): 3643 - 3654. [Abstract] [Full Text] [PDF]

				H. CEULEMANS and M. BOLLEN Functional Diversity of Protein Phosphatase-1, a Cellular Economizer and Reset Button Physiol Rev, January 1, 2004; 84(1): 1 - 39. [Abstract] [Full Text] [PDF]

				J. D. Petersen, X. Chen, L. Vinade, A. Dosemeci, J. E. Lisman, and T. S. Reese Distribution of Postsynaptic Density (PSD)-95 and Ca2+/Calmodulin-Dependent Protein Kinase II at the PSD J. Neurosci., December 3, 2003; 23(35): 11270 - 11278. [Abstract] [Full Text] [PDF]

				P. Jourdain, K. Fukunaga, and D. Muller Calcium/Calmodulin-Dependent Protein Kinase II Contributes to Activity-Dependent Filopodia Growth and Spine Formation J. Neurosci., November 19, 2003; 23(33): 10645 - 10649. [Abstract] [Full Text] [PDF]

				C. Sala, K. Futai, K. Yamamoto, P. F. Worley, Y. Hayashi, and M. Sheng Inhibition of Dendritic Spine Morphogenesis and Synaptic Transmission by Activity-Inducible Protein Homer1a J. Neurosci., July 16, 2003; 23(15): 6327 - 6337. [Abstract] [Full Text] [PDF]

				E. A. Kramar, J. A. Bernard, C. M. Gall, and G. Lynch Integrins Modulate Fast Excitatory Transmission at Hippocampal Synapses J. Biol. Chem., March 14, 2003; 278(12): 10722 - 10730. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help